PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
- Known as:
- PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
- Catalog number:
- arp33870_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
Related genes to: PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
- Gene:
- PNLIPRP2 NIH gene
- Name:
- pancreatic lipase related protein 2 (gene/pseudogene)
- Previous symbol:
- -
- Synonyms:
- PLRP2
- Chromosome:
- 10q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-04-28
- Date modifiied:
- 2016-02-12
Related products to: PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
Related articles to: PNLIPRP2 Antibody - C-terminal region (ARP33870_P050)
- Astaxanthin plays a vital role in pigmentation, immune function, reproduction, and antioxidation in aquatic species. To clarify the molecular mechanism of astaxanthin utilization in (), we conducted a comparative transcriptome analysis on the intestine, hepatopancreas, and muscle of , fed with an astaxanthin diet and a normal diet. A total of 144 differentially expressed genes (DEGs) were identified in three tissues between the two groups. Genes related to absorption and transport, such as and the vitellogenin receptor, were upregulated in the intestine after astaxanthin supplementation, while the ileal sodium/bile acid cotransporter-like gene was downregulated. In the hepatopancreas, genes involved in lipid storage and degradation were significantly altered at the transcriptional level, including Kruppel 1-like, , δ(7)-sterol 5(6)-desaturase-like, and . In the muscle, the expression of the gene was significantly upregulated, while several actin and troponin genes were significantly downregulated. Furthermore, GSEA analysis on the transcriptomes of three tissues revealed that astaxanthin supplementation influenced the expression of genes related to antioxidation and growth, indicating that astaxanthin may have a positive impact on the growth, development, and resistance of organisms. The data from this research provide valuable insights into elucidating the molecular mechanisms underlying astaxanthin absorption and metabolism and also offer guidance for the application of astaxanthin in the aquaculture of economically important crustaceans. - Source: PubMed
Publication date: 2025/05/01
Han YuminYu YangZhang ChengsongLi ShihaoYuan JianboLi Fuhua - Chronic pancreatitis is a long-term fibroinflammatory condition of the pancreas with varying incidences across countries. The recent increase in its occurrence implies the involvement of genetic, hereditary, and unconventional risk factors. However, there is a lack of updated literature on recent advances in genetic polymorphisms of chronic pancreatitis. Therefore, this review aims to present recent findings on the genetic implications of chronic pancreatitis based on individual gene mechanisms and to discuss epigenetics and epistasis involved in the disease. Four mechanisms have been implicated in the pathogenesis of chronic pancreatitis, including premature activation of proteases, endoplasmic reticulum stress, ductal pathway dysfunction, and inflammatory pathway dysfunction. These mechanisms involve genes such as . Studying genetic polymorphisms on the basis of altered genes and their products may aid clinicians in identifying predispositions in patients with and without common risk factors. Further research may also identify associations between genetic predispositions and disease staging or prognosis, leading to personalized treatment protocols and precision medicine. - Source: PubMed
Publication date: 2023/11/22
Khan ErumChakrabarty SouraShariff SanobarBardhan Mainak - Spermatogenesis is a complicated process of germ cell differentiation that occurs within the seminiferous tubule in the testis. Peritubular myoid cells (PTMCs) produce major components of the basement membrane that separates and ensures the structural integrity of seminiferous tubules. These cells secrete niche factors to promote spermatogonial stem cell (SSC) maintenance and mediate androgen signals to direct spermatid development. However, the regulatory mechanisms underlying the identity and function of PTMCs have not been fully elucidated. In the present study, we showed that the expression of pancreatic lipase-related protein 2 (Pnliprp2) was restricted in PTMCs in the testis and that its genetic ablation caused age-dependent defects in spermatogenesis. The fertility of Pnliprp2 knockout animals (Pnliprp2) was normal at a young age but declined sharply beginning at 9 months. Pnliprp2 deletion impaired the homeostasis of undifferentiated spermatogonia and severely disrupted the development and function of spermatids. Integrated analyses of single-cell RNA-seq and metabolomics data revealed that glyceride metabolism was changed in PTMCs from Pnliprp2 mice. Further analysis found that 60 metabolites were altered in the sperm of the Pnliprp2 animals; notably, lipid metabolism was significantly dysregulated. Collectively, these results revealed that Pnliprp2 was exclusively expressed in PTMCs in the testis and played a novel role in supporting continual spermatogenesis in mice. The outcomes of these findings highlight the function of lipid metabolism in reproduction and provide new insights into the regulation of PTMCs in mammals. - Source: PubMed
Publication date: 2023/07/19
Tao Hai-PingLu Teng-FeiLi ShuangJia Gong-XueZhang Xiao-NaYang Qi-EnHou Yun-Peng - Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially discussed. We perform a genome-wide meta-analysis of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9758 subjects and detect ten independent genome-wide significant SNPs at seven genomic loci. We confirm previously established associations at ABCG5/8 and ABO and demonstrate an extended locus heterogeneity at ABCG5/8 with different functional mechanisms. New loci comprise HMGCR, NPC1L1, PNLIPRP2, SCARB1 and APOE. Based on these results, we perform Mendelian Randomization analyses (MR) revealing a risk-increasing causal relationship of sitosterol serum concentrations and CAD, which is partly mediated by cholesterol. Here we report that phytosterols are polygenic traits. MR add evidence of both, direct and indirect causal effects of sitosterol on CAD. - Source: PubMed
Publication date: 2022/01/10
Scholz MarkusHorn KatrinPott JanneGross ArndKleber Marcus EDelgado Graciela EMishra Pashupati PrasadKirsten HolgerGieger ChristianMüller-Nurasyid MartinaTönjes AnkeKovacs PeterLehtimäki TerhoRaitakari OlliKähönen MikaGylling HelenaBaber RonnyIsermann BerendStumvoll MichaelLoeffler MarkusMärz WinfriedMeitinger ThomasPeters AnnetteThiery JoachimTeupser DanielCeglarek Uta - Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PTL or PNLIP) and its family members, pancreatic lipase-related protein 1 (PNLIPRP1or PLRP1) and pancreatic lipase-related protein 2 (PNLIPRP2 or PLRP2). Unlike the family's other members, PNLIPRP2 plays an elemental role in lipid digestion, especially for newborns. Therefore, if genetic factors cause gene mutation, or other factors lead to non-expression, it may have an effect on fat digestion and absorption, on the susceptibility to pancreas and intestinal pathogens. In this review, we will summarize what is known about the structure and function of PNLIPRP2 and the levels of PNLIPRP2 and associated various pathological states. - Source: PubMed
Publication date: 2021/07/05
Zhu GuoyingFang QingZhu FengshangHuang DongpingYang Changqing