CTRL antibody - N-terminal region (ARP33863_P050)
- Known as:
- CTRL (anti-) - N-terminal region (ARP33863_P050)
- Catalog number:
- arp33863_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CTRL antibody - N-terminal region (ARP33863_P050)
Related genes to: CTRL antibody - N-terminal region (ARP33863_P050)
- Gene:
- CTRL NIH gene
- Name:
- chymotrypsin like
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-29
- Date modifiied:
- 2016-03-17
Related products to: CTRL antibody - N-terminal region (ARP33863_P050)
Related articles to: CTRL antibody - N-terminal region (ARP33863_P050)
- The uncinate fasciculus (UF) is a long-range association fiber tract connecting the anterior temporal lobe with the orbitofrontal cortex and has been linked to a multitude of physiological and pathophysiological conditions such as aging, epilepsy, and the vulnerability to psychopathology posed by a history of childhood abuse (CA). Since the myelin sheath is highly enriched in lipids, changes in white matter (WM) microstructure observed via neuroimaging may reflect alterations in the myelin lipid profile. Given that the UF does not exist in rodents, its molecular properties are highly understudied. Therefore, we sought to quantify the phospholipid FA and cholesterol quantities of the human postmortem UF and evaluate any lipid-related or myelin-constituent gene/protein changes associated with age and history of CA. UF samples were analyzed from individuals with depression who died by suicide with (DS-CA) or without (DS) severe CA, and control individuals (CTRL), with an age span of 15 to 85 years. Phospholipids were separated by thin-layer chromatography; FAs and nonderivatized cholesterol were quantified by gas chromatography-flame ionization detection. The relative expression of myelin-constituent genes and proteins was measured by RT-qPCR and immunoblotting, respectively. We found no robust relationships between CA or depression and lipid measures or myelin-constituent gene/protein levels. In contrast, phospholipids showed pronounced age effects that differed by fraction, with an overall trend of monounsaturated FAs increasing and long-chain omega-6 polyunsaturated FAs decreasing with age. The expression of most myelin-constituent genes and proteins declined with age; PLP1 and MAG showed significant decreases. Therefore, changes in lipid composition and lipid-protein interactions likely contribute to age-related myelin deficits and may in part underlie age-associated cognitive decline. - Source: PubMed
Perlman KellyChen Chuck TSmith Mackenzie EKim JohnTurecki GustavoBazinet Richard PMechawar Naguib - Bacterial wilt caused by Ralstonia solanacearum is one of the most significant diseases affecting potato plants worldwide. The current study aims to investigate the role of endophytic bacteria, Bacillus safensis Har267, B. pumilus Fer469, B. zhangzhouensis Kh690, B. aerius Kh867, and B. wiedmannii Ah945, for their potential to control wilting development. The effects of cell-free culture supernatant (CFCS) from endophytic bacteria on the virulence traits of R. solanacearum cells in vitro, as well as the induction of disease resistance in inoculated plants under greenhouse conditions, were investigated. Two endophytic bacteria, Kh690 and Ah945, significantly reduced wilting symptoms. Moreover, the CFCS of endophytic bacteria significantly reduced various motility behaviors, including swarming, swimming, and twitching, as well as chemotaxis migration toward potato root extract, exopolysaccharide (EPS) production, and biofilm formation by R. solanacearum. GS-MS analysis revealed that the CFCS of endophytic bacteria contains various compounds with potential antibacterial activities. Statistical analysis revealed that colonization of the root and shoot by R. solanacearum was significantly reduced in plants pre-treated by endophytic bacteria. Our results, based on statistical analysis, showed that the endophytic bacteria significantly increased plant defensive enzyme activities such as catalase (CAT), polyphenol oxidase (PPO), and peroxidase (POD), compared to non-inoculated control (Ctrl-). The Kh690 and Ah945 strains significantly upregulated the expression level of NPR1, a defense gene related to plant resistance, suggesting the induction of resistance against pathogen attack. - Source: PubMed
Publication date: 2026/04/18
Yousefvand MaryamHarighi BehrouzZaheriani DavoodAzizi Abdolbaset - Neurodegeneration is a hallmark of multiple sclerosis (MS) that affects both the structure (e.g., total or regional brain volume) and function (e.g., corticospinal excitability) of the central nervous system (CNS), driving disability progression. Consequently, lower extremity neuromuscular function and physical function are preferentially affected, ultimately contributing to a reduced quality of life. While several studies have examined the effects of resistance training (RT) and other exercise modalities on CNS structure in persons with MS (pwMS), only a few studies have evaluated changes in CNS function, even though it may adapt much more rapidly than CNS structures. To our knowledge, no previous study has examined whether progressive RT (PRT) induces changes in corticospinal excitability (CSE) for the lower extremities of pwMS. - Source: PubMed
Publication date: 2026/04/15
Andersen Therese MRiis HjalteTankisi HaticeMamoei SepehrLangeskov-Christensen MartinDalgas UlrikLundbye-Jensen JesperHvid Lars G - Bipolar disorder (BD) is characterized by marked emotion dysregulation and high familial risk. Identifying early biological markers of vulnerability in BD, including unaffected offspring, is critical to improve risk stratification and intervention, and glymphatic-associated processes may contribute to this vulnerability. We examined 237 participants, including 97 patients with emotion dysregulation disorders (EDD; 34 BD, 33 borderline personality disorder [BPD], 30 attention-deficit/hyperactivity disorder [ADHD]), 67 offspring of EDD patients (EDDoff; including 23 BD offspring [BDoff]), and 73 healthy controls (CTRL). All participants underwent clinical assessments, diffusion and resting-state functional MRI, and serum immune and neurotrophic biomarker sampling. Perivascular diffusion was estimated using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS), a diffusion-derived perivascular metric proposed to relate to glymphatic-associated processes, and compared across groups. To explore multimodal correlates of DTI-ALPS, principal component analyses (PCA) were conducted across clinical, biological, and neuroimaging domains. BD patients and BDoff showed significantly reduced DTI-ALPS compared with CTRL, ADHD, and BPD, supporting its potential role as a vulnerability-related imaging feature for BD. By contrast, ADHD and BPD showed comparable or higher DTI-ALPS relative to controls. Across participants, DTI-ALPS was associated with components reflecting white matter integrity and serum immune and neurotrophic markers. Within BD, lower DTI-ALPS correlated with more manic episodes and poorer working memory. Reduced DTI-ALPS may represent a BD-specific vulnerability-related feature, observable in both patients and at-risk offspring, and not shared by other emotion dysregulation disorders. Multimodal associations with white matter, inflammation, and symptoms underscore its relevance for risk stratification in high-risk populations. - Source: PubMed
Publication date: 2026/04/09
Pascucci AlessandroDelavari FarnazVille Dimitri Van DeEliez StéphanPiguet CamilleSaccaro Luigi F - This study investigated the protective effect of Salidroside (SAL) against cerebral ischemia-reperfusion (I/R) injury and its role in regulating nicotinamide phosphoribosyltransferase (NAMPT)-mediated neuroinflammation and damage. - Source: PubMed
Publication date: 2026/03/31
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