CD40LG antibody - middle region (ARP33831_P050)
- Known as:
- CD40LG (anti-) - middle region (ARP33831_P050)
- Catalog number:
- arp33831_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CD40LG antibody - middle region (ARP33831_P050)
Related genes to: CD40LG antibody - middle region (ARP33831_P050)
- Gene:
- CD40LG NIH gene
- Name:
- CD40 ligand
- Previous symbol:
- HIGM1, IMD3, TNFSF5
- Synonyms:
- CD40L, TRAP, gp39, hCD40L, CD154
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD40LG antibody - middle region (ARP33831_P050)
Related articles to: CD40LG antibody - middle region (ARP33831_P050)
- Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow nitric oxide (sNO) reduces these responses, b) what the temporal trajectory of these markers post-ECMO commencement is, and c) how serum marker concentrations are associated with survival. Fifty-three patients were randomized (25 sNO, 28 control). Serum levels of inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, TNF-α), complement (C1q, C3, C4, C5a, C9, factor H, factor B), immune regulators (CD40L, P-Selectin), and coagulation factors (PF4, MBL, ADAMTS13) were measured at (t0) and 1, 12, 24 hours post (t1-t3) ECMO initiation. Sweep flow nitric oxide did not alter serum biomarker trajectories. Across sNO and control groups, serum marker concentrations declined from t0 to t1 with variable patterns thereafter, but no consistent ECMO-associated elevation. Elevated IL-6 and IL-8 before and after ECMO commencement were associated with mortality, whereas higher P-Selectin, CD40 Ligand, and PF4 correlated with survival. Sweep flow nitric oxide did not modify markers of inflammation, endothelial, or coagulation activation during ECMO. Evidence of an ECMO-induced cytokine storm was absent, but serum biomarkers predicted mortality in ECMO-supported neonates and children. - Source: PubMed
Publication date: 2026/04/17
Mattke Adrian CSchlapbach Luregn JTakashima MariJohnson Kerry EMcPherson StephenVenugopal Prem SBlumenthal Antje - This research aimed to develop an enhanced CT-based radiomics model capable of predicting CD40LG expression. - Source: PubMed
Publication date: 2026/04/14
Fan LiyuanShi LiangYuan HaokunWang ZhongchaoWang JinghanXian FengMu Yandong - The tumor necrosis factor (TNF) superfamily includes cytokines that play a role in biological functions such as cell cycle regulation, cell death, and inflammatory responses. The main objective of this research is to investigate the effects of naturally occurring compounds on the TNF receptor family using in silico methods, thereby revealing their potential for anticancer and anti-inflammatory activity. - Source: PubMed
Publication date: 2026/04/08
Akkaya HaticeÖzmaldar Aydın - Parental history of dementia is associated with increased dementia risk. We investigated whether having a parent with dementia is associated with increased peripheral inflammation in middle-aged adults. - Source: PubMed
Winford Edric DHuber Benjamin DSeblova DominikaPyne JeffreyAvila-Rieger Justina FTurney Indira CMazen Jessica ABrickman Adam MManly Jennifer J - Pulmonary immune homeostasis requires tight control of adaptive responses. Integrin β3 is a well-known mediator of cell adhesion and platelet function. However, its role in adaptive immunity, especially in B cell responses, remains unclear. - Source: PubMed
Publication date: 2026/03/24
Liu ShuangWang KaiwenChen JiayiShen YanRuan ZhengWang KankanXi XiaodongMao Jianhua