FOXP2 antibody - N-terminal region (ARP33750_T100)
- Known as:
- FOXP2 (anti-) - N-terminal region (ARP33750_T100)
- Catalog number:
- arp33750_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FOXP2 antibody - N-terminal region (ARP33750_T100)
Related genes to: FOXP2 antibody - N-terminal region (ARP33750_T100)
- Gene:
- FOXP2 NIH gene
- Name:
- forkhead box P2
- Previous symbol:
- TNRC10, SPCH1
- Synonyms:
- CAGH44
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-20
- Date modifiied:
- 2016-10-05
Related products to: FOXP2 antibody - N-terminal region (ARP33750_T100)
Related articles to: FOXP2 antibody - N-terminal region (ARP33750_T100)
- Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder; however, its genetic architecture remains poorly explored in Indigenous populations. This study aimed to analyze and characterize genetic variation in 11 genes (ADGRL3, CDH8, DCC, DUSP6, FOXP1, FOXP2, MEF2C, PCDH7, SEMA6D, SORCS3, and ST3GAL3) previously implicated in ADHD, in an indigenous sample, comparing them with reference populations from the 1000 Genomes Project. Exome data from 64 individuals representing 12 Indigenous groups from the Brazilian Amazon were analyzed. Among the identified, 99 met the inclusion criteria. Four previously unreported variants in the developed reference datasets were identified in ADGRL3, DCC, and FOXP2. Significant differences in allele frequencies were observed for 56 variants compared with continental populations. Multidimensional scaling analysis indicated genetic differentiation of the Indigenous group in relation to other populations. This study highlights the distinct genetic profile of Amazonian Indigenous populations, likely shaped by demographic and evolutionary processes such as genetic drift and founder effects. The identification of exclusive variants and marked allele frequency differences reinforces the importance of including historically underrepresented populations in genomic studies related to ADHD and neurodevelopment, contributing to a broader understanding of human genetic diversity. - Source: PubMed
Publication date: 2026/08/11
de Matos Hirlesson PaixãoMonte NatashaAguiar Kaio Evandro Cardosode Cássia Calderaro RitaSantos Aline PasquiniRodrigues Juliana Carla GomesRibeiro-Dos-Santos André MaurícioDe Souza Sandro JoséRibeiro-Dos-Santos ÂndreaGuerreiro João FariasSantos Sidney Emanuel Batista DosSantos Ney Pereira Carneiro Dos - The dorsomedial hypothalamic nucleus and perifornical area (DMH/PeF), historically identified as the hypothalamic defence area, plays a key role in orchestrating autonomic and respiratory adjustments during threat-related states. To investigate how activation of this region affects upper-airway and respiratory motor circuits, we examined its anatomical and functional interactions with laryngeal-related medullary nuclei using combined immunohistochemical mapping and physiological recordings in spontaneously breathing anaesthetised rats. Neuronal activation was assessed using c-Fos immunohistochemistry (c-Fos-ir) combined with ChAT and FoxP2 labelling to identify motoneurons and non-motoneuronal populations across the compact, semicompact and loose formations of the nucleus ambiguus (nA), as well as within the nucleus retroambiguus (nRA), during DMH/PeF electrical stimulation. Hypothalamic activation produced a clear subdivision-specific recruitment in the nA, with significant ipsilateral increases in c-Fos-ir within the semicompact (motoneurons, < 0.001; non-motoneurons, < 0.05) and compact formations (non-motoneurons, < 0.05). The nRA also exhibited robust ipsilateral activation (non-motoneurons, < 0.001). FoxP2-positive neurons remained stable across groups, indicating that FoxP2 reflects neuronal phenotype rather than acute activation. A second set of experiments evaluated the functional impact of electrical and chemical (glutamate) DMH/PeF activation on subglottic pressure, an index of laryngeal resistance. Both stimulation modalities produced a marked reduction in subglottic pressure ( < 0.001 and < 0.01), accompanied by a reproducible autonomic-respiratory pattern characterised by tachypnoea, tachycardia and a pressor response. Overall, our results provide new insight into how hypothalamic circuits regulate subglottic pressure and laryngeal activity, suggesting that DMH/PeF activation is associated with the recruitment of specific nA and nRA domains, which may contribute to the adjustment of upper-airway patency during defensive responses. - Source: PubMed
Publication date: 2026/07/22
Carrillo-Franco LauraGonzález-García MartaMorales-Luque CarmenRivera AliciaGago BelénPonce-Velasco MarinaDawid-Milner Marc StefanLópez-González Manuel Víctor - Sound perception requires sensory information processing through brain regions where alterations to cellular composition or function may impact auditory-relevant behaviors. The inferior colliculus (IC) is a central midbrain hub for integrating and transforming auditory information prior to relay to the forebrain. However, the molecular logic that underlies the cell type specification of the IC remains unknown. Here, using a multiomic approach, we define the transcriptional and chromatin landscapes that underlie IC cell type diversity. We identify distinct glutamatergic neuronal subclasses and the gene regulatory programs that drive their specification, maturation, and survival. We show that perturbation to the transcription factor FOXP2, previously implicated in speech and language as well as brain disorders with altered sensory processing, selectively disrupts the specification and survival of three newly defined glutamatergic neuronal subclasses. We link these molecular and cellular disruptions to functional deficits in auditory processing including altered brainstem and forebrain responses and impaired behavioral sensitivity to acoustic stimuli. Together, these results link gene regulatory mechanisms to cell type-specification in the IC, providing insight into how molecular control of neuronal identity in midbrain sensory centers contributes to systems-level processing of sound. - Source: PubMed
Publication date: 2026/07/24
Jankovic MirandaHuang Yuan-TaiHolley AndrewKirkland SophiaKulkarni AshwinikumarSakano HitomiGibson Jay RKonopka Genevieve - Foxp2 is a transcription factor essential for the development and function of neural circuits involved in language. Although its expression has been extensively characterized in the cortex and basal ganglia, its organization within the adult thalamus remains poorly understood. In this study, we present a comparative analysis of Foxp2 protein expression across thalamic nuclei in mice, rats, and macaques, with a focus on nuclei associated with higher-order cognitive functions and language-related circuits in humans. We found that Foxp2 is expressed in most thalamic nuclei across species, with a consistent absence in the reticular nucleus and zona incerta. Expression was highest in midline and intralaminar nuclei, whereas the anterior group showed low and variable expression among species. Macaques exhibited broader and, in some nuclei, more intense FoxP2 expression, particularly in associative regions such as the pulvinar and parts of the ventral group, consistent with differences in thalamocortical organization across species. This distribution suggests a conserved role for Foxp2 in shaping thalamic circuits supporting sensorimotor integration, attention, memory, and linguistic processing. Phylogenetic comparisons suggest that enhanced Foxp2 expression in associative thalamic territories in primates may be related to the increased complexity of thalamocortical circuits. These findings provide molecular and anatomical insights into the organization of thalamocortical networks and may offer a framework for understanding their involvement in higher-order cognitive functions and neuropsychiatric disorders. - Source: PubMed
Publication date: 2026/07/24
Sánchez-Moreno BlancaUceda-Heras Aliciade la Fuente-Fernández MaríaGarcía-Cabezas Miguel ÁngelCavada CarmenGilabert-Juan Javier - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Animal models are widely used to investigate the underlying mechanisms of ADHD and evaluate therapeutic interventions. Zebrafish (Danio rerio) have emerged as promising model organisms due to their genetic similarity to humans, rapid development, and suitability for behavioural and pharmacological studies. - Source: PubMed
Publication date: 2026/07/22
Sivakumar DiveyaaBessho YasumasaRamli Rosmaliza