CLOCK antibody - N-terminal region (ARP33730_P050)
- Known as:
- CLOCK (anti-) - N-terminal region (ARP33730_P050)
- Catalog number:
- arp33730_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLOCK antibody - N-terminal region (ARP33730_P050)
Related genes to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody - N-terminal region (ARP33730_P050)
Related articles to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Circadian rhythms (CRs) are regulated by the body's internal biological clock and influence various physiological processes such as sleep-wake cycles, hormone secretion, cardiovascular activity, core body temperature, and metabolism. Disruption to these rhythms due to irregular sleep schedules, shift work, artificial light exposure, and modern lifestyle changes are associated with adverse health outcomes. This review examines how human biological clocks have been shaped by evolutionary adaptations to natural light-dark cycles, developmental shifts in chronotype across the lifespan, and cultural factors that structure sleep behaviour across societies. It draws on evidence of segmented sleep patterns in early human societies and age-related shifts from delayed sleep in adolescence to earlier sleep-wake patterns in older adulthood. It further explores how urbanization, changes in work and social schedules, and the expansion of digital technologies and artificial light contribute to circadian misalignment. Databases such as Google Scholar, Scopus, PubMed, and Web of Science were searched systematically in accordance with PRISMA guidelines. Following a screening process, 26 studies met the eligibility criteria and were included in the final synthesis. The selected literature was examined from an anthropological perspective to understand the cross-cultural variation in sleep patterns and to explore how social organization and technological environments shape temporal behaviour. The thematic synthesis highlights how human sleep patterns have evolved, how chronotypes shift with age, how sociocultural practices shape sleep diversity across groups, and how modern lifestyles contribute to circadian misalignment. Drawing on global context and emerging evidence from India, this review identifies areas for future research and emphasizes the need to integrate biological and socio-cultural perspectives to promote overall health and well-being. - Source: PubMed
Publication date: 2026/06/01
Haroon HabibaPedada Durga Rao - - Source: PubMed
Publication date: 2026/05/28
Smith Jacob - We introduce Thermodynamic Natural Gradient Descent (NGD-T), an optimizer that enforces a physical speed-cost constraint by combining Fisher-preconditioned updates with a dissipation-aware step-size regulator. While natural gradient methods are known to follow the steepest descent direction in information geometry, we provide a thermodynamic reinterpretation: Natural Gradient Flow uniquely minimizes instantaneous irreversible dissipation for a fixed loss decrease. NGD-T implements this principle in discrete updates by (i) preconditioning gradients with an approximate inverse Fisher, (ii) computing the geometric norm [Formula: see text], and (iii) mapping a user-specified dissipation budget [Formula: see text] to a step size [Formula: see text] that saturates the speed-cost bound. We present numerically stable constructions for rank-deficient Fisher estimates, a hybrid nullspace fallback, and scalable K-FAC integration with eigendecomposition caching. On CIFAR-10, ImageNet, and transformer architectures, NGD-T matches or exceeds Adam in convergence while substantially reducing predicted irreversible dissipation and maintaining comparable wall-clock time. NGD-T provides a principled, tunable trade-off between learning speed and thermodynamic cost with theoretical convergence guarantees. - Source: PubMed
Publication date: 2026/06/01
You Barco Jie - Radiogenic helium (⁴He) has long been recognised as a potential indicator of groundwater residence time, but its quantitative application has remained largely site-dependent because helium concentrations integrate production, crustal fluxes, transport and mixing processes. In contrast, krypton-81 (⁸¹Kr) provides a conservative chronometer for old groundwater, yet paired ⁴He-⁸¹Kr datasets have remained extremely scarce. Here we compile a uniquely expanded global dataset of groundwater samples with paired dissolved radiogenic ⁴He concentrations and independently determined ⁸¹Kr residence times across diverse aquifer systems. Dissolved ⁴He increases monotonically with groundwater age over nearly three orders of magnitude and follows a simple empirical scaling for waters older than ~ 50 kyr that is robust to the exclusion of individual basins. More than 80% of helium-derived ages agree with corresponding ⁸¹Kr residence times within a factor of three under conservative cross-basin validation. These results demonstrate that radiogenic helium, when anchored to an absolute chronometer, can serve as a transferable first-order proxy for groundwater residence time, providing a practical basis for global groundwater age screening and targeted application of high-precision dating methods. - Source: PubMed
Publication date: 2026/06/01
Matsumoto TakuyaPinti Daniele LuigiJiang WeiLu Zheng-TianYang Guo-MinMueller PeterAbdelouahab RachidMoulla Adnane SouffiHillegonds DarrenMabry JenniferRomeo Nicolo - Anxiety disorders are prevalent and can greatly impact well-being. The biological mechanisms behind anxiety are not fully understood, but growing evidence suggests a role for DNA methylation. Here, we conduct a large-scale methylome-wide association study of lifetime anxiety in 14,443 participants (1817 cases and 12,626 controls) in whole blood, and, through epigenomic deconvolution, 12 different blood cell types. We detect four CpG associations at methylome-wide significance in whole blood, and a range between 15 and 124 associations among the cell types. Top cell type-specific findings include genes potentially involved in stress response such as FAM171A2 and VIPAS39 and genes that have been previously linked to anxiety, such as NCOR1. Whole blood and all cell type-specific findings significantly overlap with findings from two previous methylome-wide association studies of lifetime anxiety and an anxiety GWAS, suggesting results are robust. Pathway analyses broadly implicate anxiety-related impacts on cellular stress response. Analyses of five epigenetic clocks suggest DNA methylation-based phenotypic aging and pace of aging may be accelerated in anxiety. Our results support a cell type-specific relationship between DNA methylation and anxiety and highlight the utility of including cell type-specific analyses in whole blood studies of DNA methylation. - Source: PubMed
Publication date: 2026/06/01
Ingram Sarah JRamachandruni SrimannCarreras-Gallo NataliaDwaraka Varun BSmith RyanHettema John Mvan den Oord Edwin J C GClark Shaunna L