CLOCK antibody - N-terminal region (ARP33730_P050)
- Known as:
- CLOCK (anti-) - N-terminal region (ARP33730_P050)
- Catalog number:
- arp33730_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLOCK antibody - N-terminal region (ARP33730_P050)
Related genes to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody - N-terminal region (ARP33730_P050)
Related articles to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Lifespan is increasing such that within a few decades approximately twenty percent of the world's population is expected to be greater than sixty years of age. In concert with global aging of the population, neurodegenerative disorders have become the leading cause of disability with dementia now the seventh leading cause of death worldwide. Despite multi-faceted treatment approaches for disorders of cognition that include Alzheimer's disease and multiple sclerosis, present therapies ultimately cannot halt disease progression and eventually cognitive impairment continues unabated. Furthermore, co-morbidities, such as metabolic disorders with diabetes mellitus, also lack strategies to prevent disease progression. Given these clinical challenges for cognitive loss, innovative avenues of investigation that involve mammalian chronobiology with circadian rhythm clock genes and related pathways of aging, cellular senescence, oxidative stress, metabolic dysfunction, sleep fragmentation, apolipoprotein E, programmed cell death, silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae), nicotinamide adenine dinucleotide, the gut microbiota, and glucagon-like peptide-1 receptor agonism may offer exceptional promise for forging new strategies for cognitive disease treatment. These pathways are intimately linked to circadian rhythm processes, are complex in generating biological outcomes, can broadly influence clinical translation of both short- and long-term considerations for cognitive disease care, and necessitate dissection of their precise regulatory mechanisms with the benefit from early diagnostic platforms as well as artificial intelligence and machine learning applications to foster translation of these pathways into effective clinical treatments. - Source: PubMed
Publication date: 2026/08/25
Maiese Kenneth - Circadian disruption is strongly associated with alcohol use disorder (AUD), but insight into the underlying brain-region and sex-specific mechanisms is limited. The function of the circadian clock gene Bmal1 within the striatum has been linked to alcohol drinking, yet its role within functionally distinct striatal subregions has not been systematically examined. - Source: PubMed
Publication date: 2026/09/19
Darvishmolla MahgolCourtemanche RichardAmir Shimon - Single camera markerless motion capture is a low-cost, accessible motion capture technology that could be used to improve clinical decision making. However, current models lack the spatial and anatomical fidelity required for research-grade analysis, which prevents accurate modelling of 3D human gait dynamics. The purpose of the current study was threefold, 1) to develop a means of predicting 3D gait kinematics using consumer-grade video inputs, 2) to assess the accuracy of the method across a variety of ecologically relevant perturbations such as camera location, body size, and clothing characteristics, and 3) to assess the utility of the 3D gait kinematics to score walking gait quality. Treadmill walking data were recorded from four different camera angles, and a diverse range of participant characteristics and clothing conditions. A single LSTM deep neural network was trained from each of the four camera angles to predict the 3D anatomical landmarks recorded from a research-grade motion capture system consisting of 17 body-worn inertial measurement units. The model trained on data from the camera positioned on the front right (i.e., 2o'clock) of the treadmill demonstrated the best-performing model (RMSE of 2.97 cm and 4.24 degrees). Significant effects of clothing characteristics, gait strategy, and anthropometrics on model performance were observed. Acceptable agreement was observed between the gait profile scores calculated from the LSTM and research-grade motion capture system (RMSE = 2.07, ICC = 0.65). These results demonstrate the potential for single-camera markerless motion capture to produce clinical grade data in a healthy population, thereby improving the accessibility of clinical gait assessments. - Source: PubMed
Publication date: 2026/09/10
Vellucci Chris LRatke Emma JGuleria AkankshaBeaudette Shawn M - Cyanobacteria are the only prokaryotes to have evolved oxygenic photosynthesis, transforming the geochemistry and biology of the planet. They exhibit remarkable morphological diversity and represent one of the earliest known multicellular organisms, including filamentous growth and cellular differentiation. However, the genomic mechanisms underlying their repeated transitions between unicellularity and multicellularity remain unresolved. Here, we implement phylogenomic and Bayesian molecular clock analyses, estimate ancestral protein-coding gene contents, and examine gene gains and losses associated with major morphological transitions across their phylogeny. Our analyses reveal a dynamic evolutionary history characterized by independent gains and losses of multicellularity-associated traits. Convergent evolution plays a crucial role in the repeated emergence of similar gene functions, particularly within pathways related to signal transduction, cell division, and transcriptional control. Filamentous lineages consistently preserve genes that support cellular coordination and structural integration, while reversions to unicellularity often involve losing genes linked to motility, regulatory complexity, and cytoskeletal organization. Notably, many lost genes trace back to deep ancestral innovations, suggesting that reductions in complexity often reverse previous genomic acquisitions. Together, these findings highlight the modular and reversible nature of cyanobacterial morphological evolution and illustrate how functional convergence affects genome architecture during significant phenotypic transitions. - Source: PubMed
Publication date: 2026/09/21
Yang LingyunBianchini GiorgioPaps JordiSánchez-Baracaldo Patricia - We study the collective dynamics of metronomes coupled through a common platform that is free to move in two spatial dimensions, extending Huygens' classical experiment on synchronizing pendulum clocks. Allowing planar motion of the coupling medium gives rise to emerging robust synchronization patterns. Experiments reveal a geometry-induced transition between two qualitatively distinct collective states: a translational mode, in which the metronomes synchronize with shifted phases and drive planar translation of the platform, and a rotational mode, characterized by in-phase synchronization and oscillatory rotation about the platform's center of mass. The transition between these modes is controlled by the spatial arrangement of the oscillators and is naturally interpreted as a symmetry-related bifurcation. First-principles multibody simulations reproduce the observed behaviors, while application of the Harmonic Balance method enables analytical continuation and characterization of both stable and unstable synchronized solutions. These results highlight how multidimensional dynamical coupling and symmetry alone can organize collective motion, providing a minimal mechanical setting for studying emergent synchronization phenomena in nonlinear oscillator networks. - Source: PubMed
Hoogesteger M MPogromsky A YNijmeijer H