CLOCK antibody - N-terminal region (ARP33730_P050)
- Known as:
- CLOCK (anti-) - N-terminal region (ARP33730_P050)
- Catalog number:
- arp33730_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLOCK antibody - N-terminal region (ARP33730_P050)
Related genes to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody - N-terminal region (ARP33730_P050)
Related articles to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Ultrafast charge transfer (CT) lies at the heart of molecular and electronic functionality. We develop a Fano-based core-hole clock (FCHC) method that captures coherent coupling between localized excitons and the directly populated delocalized CT continua in resonant Auger scattering. Applied to sulfur KLL Auger spectra of a conductive organic polymer, FCHC reveals clear Fano interference and a CT time of 27±1.8 fs, demonstrating that the conventional core-hole clock model underestimates the CT dynamics timescale. We establish FCHC as a robust method for probing ultrafast CT in complex molecular systems. - Source: PubMed
Liu Ji-CaiVelasquez NicolasKimberg VictorSarkar SayantanTravnikova OksanaIsmail IyasGuillemin RenaudZhang ManKrasnov PavelIannuzzi MarcellaOdelius MichaelPüttner RalphPiancastelli Maria NovellaSimon MarcGel'mukhanov FarisMarchenko Tatiana - Transfemoral access remains the preferred route for transcatheter aortic valve replacement (TAVR); however, severe peripheral artery disease (PAD) and unfavorable anatomy can result in the preclusion of conventional access. Transseptal antegrade TAVR may offer another avenue in such cases. - Source: PubMed
Publication date: 2026/08/17
Ali Toheed-FatimaGolzarian HafezKleman AnnaKnous MalloryNoll HaileyMacke AndrewLaird AmandaScarbrough Emilie RHempfling GerriSirak JohnPatel Sandeep M - - Source: PubMed
Kemp Philippa - The circadian clock controls a vast array of cellular and organismal functions, from the molecular scale to behavior. While each cell is regimented by a cell-autonomous clock, few studies in the brain have dissected the circuit and behavioral contributions of cell-specific clocks. Relatedly, astrocytes are now known to play key roles in regulating synaptic function, circuit activity and behavior, but whether these functions are guided by astrocyte-autonomous clocks is unknown. Here, we report that post-natal deletion of the critical circadian clock gene Bmal1 in astrocytes, which abrogates core clock function in a cell type specific manner, induced expression of genes related to extracellular matrix (ECM) production, maintenance, and remodeling. Circadian variations have been shown in a specific ECM structure, perineuronal nets (PNNs), which are implicated in synaptic function and plasticity. In astrocyte-specific Bmal1 knockouts, hippocampal PNN abundance was decreased, and the circadian rhythm of these structures was also abolished. In line with evidence implicating PNNs, and the ECM in general, in synaptic function and plasticity, we found that astrocyte-specific Bmal1 KO mice had increased synaptic strength but blunted long term potentiation (LTP), as well as impaired learning and memory performance in a novel object recognition task. Taken together, these findings suggest that the astrocyte circadian clock regulates circadian rhythms in perineuronal net abundance as well as synaptic plasticity and behavioral learning and memory. - Source: PubMed
Smith Philip CQuillin Elsa ILefton Katheryn BMcKee Celia ADang BrendanPapouin ThomasMusiek Erik S - Circadian rhythms regulate sleep-wake cycles, hormonal secretion, metabolism, and immune responses. Disruption of these rhythms is linked to the onset and progression of various neurological diseases. Emerging evidence suggests that exercise, a non-photic zeitgeber, can modulate circadian function at both central and peripheral levels by regulating core clock gene expression, synchronizing hormonal and metabolic rhythms, and reducing neuroinflammation. Through these mechanisms, exercise enhances the amplitude, stability, and phase alignment of circadian rhythms and may promote physiological resilience. - Source: PubMed
Demura MunehiroGregory PenelopeFukuda NoritoLo Eng HArai Ken