CLOCK antibody - N-terminal region (ARP33730_P050)
- Known as:
- CLOCK (anti-) - N-terminal region (ARP33730_P050)
- Catalog number:
- arp33730_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLOCK antibody - N-terminal region (ARP33730_P050)
Related genes to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody - N-terminal region (ARP33730_P050)
Related articles to: CLOCK antibody - N-terminal region (ARP33730_P050)
- Exposure to reduced oxygen levels occurs in several real-world contexts, such as during air travel or altitude exposure, and emerging evidence suggests that hypoxia may interact with molecular pathways involved in circadian regulation. This exploratory study investigated the effects of normobaric hypoxia on circadian phase shifting in humans, compared to luminotherapy combined with exogenous melatonin. Using a randomised crossover design, 11 healthy adults (6 men, 5 women; mean age 23.3 ± 1.9 years) completed one baseline and two 48-h experimental conditions. The baseline established individual circadian markers. Both experimental conditions simulated a 4-h phase advance. In the hypoxia condition, participants were exposed to reduced oxygen levels (inspired oxygen fraction of 12%) for 2 h, beginning 2 h after habitual wake time. In the luminotherapy and melatonin condition, participants received three-hour morning light therapy (500 nm, 506 lx) at the same time point, combined with 5 mg melatonin administered 6 h before bedtime. Salivary melatonin was collected across conditions to determine dim-light melatonin onset (DLMO). Both conditions produced earlier melatonin onset compared to baseline. The luminotherapy and melatonin condition resulted in a significant phase advance of approximately 78 min. The hypoxia condition produced an average phase advance of approximately 35 min, which was not statistically significant. The present findings do not allow us to determine whether hypoxia can induce circadian phase shifts, while light and melatonin remain an effective intervention. Further research is needed to clarify mechanisms and evaluate hypoxia as a tool for circadian modulation. - Source: PubMed
Publication date: 2026/08/22
Morin RenéeForest GenevièveIsabelle-Nolet KimBourgon VincentDuval Félix-GabrielMauger Jean-FrançoisImbeault Pascal - The increase in life expectancy over the past century has been accompanied by the recognition of age as the primary risk factor for a wide range of pathologies, including cardiovascular and neurodegenerative diseases, as well as cancer. Thus, the development of interventions that slow the underlying biological processes of aging could have beneficial effects on the prevention or progression of these diseases. To evaluate such geroprotective interventions, quantifying biological damage via aging clocks-particularly those based on transcriptomic biomarkers-has become highly relevant, as they provide estimations with strong biological interpretability. However, the limited availability of transcriptomic clocks for murine experimental models has hindered the implementation of these tools in aging research and their use in evaluating interventions that may have geroprotective effects. Here, we have developed an accurate, accessible, and ready-to-use murine transcriptomic clock that provides robust age predictions for healthy mice using hepatic RNA-seq data. Applying the clock to accelerated-aging models revealed an increased transcriptomic age in progeroid syndromes, demonstrating its ability to capture aging-related biological processes. Finally, considering the main interest of these tools, we show that well-established interventions with geroprotective potential, both genetic (Snell Dwarf, Ames Dwarf, and growth hormone receptor-deficient mice) and environmental (caloric, protein, or methionine restriction, as well as rapamycin supplementation in specific contexts), reduce the transcriptomic age estimated by the clock. These findings indicate that the proposed transcriptomic clock could be a valuable tool for studying the biology of aging and for designing and evaluating potential geroprotective interventions. - Source: PubMed
Celemín-Capaldi VíctorBea GuillerminaRoiz-Valle DavidUgalde Alejandro PBárcena CleaQuirós Pedro MFreije José M P - - Source: PubMed
Publication date: 2026/08/21
Horvath Steve - Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested. Here we curate TranslAGE, a harmonized database of 51 public and private longitudinal interventional studies, and calculate a consistent set of 16 prominent epigenetic clocks for each study, along with 94 other DNA methylation (DNAm) biomarkers that can help explain the changes observed for each clock. Using this database, we discover patterns of responsiveness across a variety of interventions and DNAm biomarkers. For example, clocks trained to predict mortality or pace of aging show the strongest responses across all interventions and show consistent results with one another; pharmacological and lifestyle interventions drive the strongest responses from DNAm biomarkers; and the characteristics of the study population and study duration are key factors in determining the responsiveness of DNAm biomarkers to an intervention. Moreover, clocks with multiple subscores (that is 'explainable clocks') provide specificity and greater mechanistic insight into the responsiveness of interventions than single-score clocks. These findings can help to design future clinical trials by guiding the choice of interventions and of specific subsets of DNAm biomarkers to minimize multiple testing, study duration, study population and sample size, with the eventual aim of uncovering DNAm biomarkers that can be used as surrogate aging endpoints. - Source: PubMed
Publication date: 2026/08/21
Sehgal RaghavBorrus DanielArmstrong Jenel FGonzalez JohnKasamoto JessicaMarkov YaroslavPriyanka AhanaSmith RyanCarreras-Gallo NatàliaLasky-Su JessicaDwaraka Varun BCorley Michael JHiggins-Chen Albert - In this viewpoint article, Zhuanghua Shi and Virginie van Wassenhove discuss the past, present, and future of multisensory time perception. Drawing on decades of research, they argue that the field has undergone an important shift from the centralized internal clock toward timing as an active inference process. This framework, rooted in Bayesian models and predictive coding, suggests that our sense of time is not a passive readout but a construction that weighs evidence against contextual expectations. One thread in the discussion concerns the temporal window of integration: the authors contrast the narrow, potentially misleading windows seen with simple beeps and flashes with those, more stable, found in audiovisual speech. The authors also explore the interplay between automatic integration and top-down processes - such as attention and expectation - noting the brain's remarkable ability to rewrite recent history through postdictive inference to maintain a unified 'now'. Key controversies are raised and include whether timing relies on dedicated circuits or emerges from neural population dynamics, as well as the specific role of neural oscillations in parsing simultaneous inputs. The authors advocate for biological plausibility and the use of time-resolved encoding-decoding modeling approaches to predict brain activity. They emphasize the use of open-science practices, including the sharing of computational models and datasets. Looking ahead, the authors anticipate that AI will revolutionize the field by handling the computational complexity of massive datasets through 'vibe coding', allowing researchers to focus on fundamental theoretical insights. They advise young scientists to develop strong scientific intuitions before expanding into modeling and to remain bold in bridging multisensory perception with cognition (incl. consciousness and linguistics). The authors emphasize that multisensory timing is central for developing sensory prostheses, and a deeper understanding of how the brain achieves a seamless experience of reality. - Source: PubMed
Publication date: 2026/08/18
Shi Zhuanghuavan Wassenhove Virginie