USP3 antibody - N-terminal region (ARP33680_P050)
- Known as:
- USP3 (anti-) - N-terminal region (ARP33680_P050)
- Catalog number:
- arp33680_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- USP3 antibody - N-terminal region (ARP33680_P050)
Related genes to: USP3 antibody - N-terminal region (ARP33680_P050)
- Gene:
- USP3 NIH gene
- Name:
- ubiquitin specific peptidase 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-09
- Date modifiied:
- 2019-04-16
- Gene:
- USP22 NIH gene
- Name:
- ubiquitin specific peptidase 22
- Previous symbol:
- USP3L
- Synonyms:
- KIAA1063
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-20
- Date modifiied:
- 2014-11-18
- Gene:
- USP48 NIH gene
- Name:
- ubiquitin specific peptidase 48
- Previous symbol:
- USP31
- Synonyms:
- FLJ23277, FLJ11328, FLJ20103, FLJ23054, MGC14879
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-29
- Date modifiied:
- 2015-08-26
Related products to: USP3 antibody - N-terminal region (ARP33680_P050)
Related articles to: USP3 antibody - N-terminal region (ARP33680_P050)
- Cruciferous vegetables such as broccoli and kale have well documented chemopreventative and anticancer effects that are attributed to the presence of isothiocyanates (ITCs). ITCs modulate the levels of many oncogenic proteins, but the molecular mechanisms of ITC action are not understood. We previously reported that phenethyl isothiocyanate (PEITC) inhibits two deubiquitinases (DUBs), USP9x and UCH37. DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurodegeneration, and inflammation. Using SILAC assisted quantitative mass spectrometry, here we identify 9 new PEITC-DUB targets: USP1, USP3, USP10, USP11, USP16, USP22, USP40, USP48 and VCPIP1. Seven of these PEITC-sensitive DUBs have well-recognized roles in DNA repair or chromatin remodeling. PEITC both inhibits USP1 and increases its ubiquitination and degradation, thus decreasing USP1 activity by two mechanisms. The loss of USP1 activity increases the level of mono-ubiquitinated DNA clamp PCNA, impairing DNA repair. Both the inhibition/degradation of USP1 and the increase in mono-ubiquitinated PCNA are new activities for PEITC that can explain the previously recognized ability of ITCs to enhance cancer cell sensitivity to cisplatin treatment. Our work also demonstrates that PEITC reduces the mono-ubiquityl histones H2A and H2B. Understanding the mechanism of action of ITCs should facilitate their use as therapeutic agents. - Source: PubMed
Publication date: 2017/04/20
Lawson Ann PBak Daniel WShannon D AlexanderLong Marcus J CVijaykumar TusharaYu RunhanOualid Farid ElWeerapana EranthieHedstrom Lizbeth