CLDN23 antibody - C-terminal region (ARP33633_P050)
- Known as:
- CLDN23 (anti-) - C-terminal region (ARP33633_P050)
- Catalog number:
- arp33633_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLDN23 antibody - C-terminal region (ARP33633_P050)
Related genes to: CLDN23 antibody - C-terminal region (ARP33633_P050)
- Gene:
- CLDN23 NIH gene
- Name:
- claudin 23
- Previous symbol:
- -
- Synonyms:
- CLDNL
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-14
- Date modifiied:
- 2016-10-25
Related products to: CLDN23 antibody - C-terminal region (ARP33633_P050)
Related articles to: CLDN23 antibody - C-terminal region (ARP33633_P050)
- Colorectal cancer (CRC) progression involves complex mechanisms of invasion and metastasis. Claudin-2 (), a tight junction protein, has emerged as a key regulator paracellular permeability and its dysregulation is implicated in chronic inflammatory diseases and cancer. The present study aimed to determine the mechanisms by which deletion affects genes associated with motility and invasion of colon cancer cells. CRISPR/Cas9 was used to knock out in HCT116 cells. Subsequently, gene expression was analyzed using reverse transcription-quantitative PCR and migratory capacity was assessed using wound healing assays. deletion led to the downregulation of genes associated with motility and metastasis, including zonula occludens-1-associated nucleic acid binding protein, N-Myc downstream-regulated gene 1, and , suggesting that supports pro-migratory gene networks. These findings demonstrated that regulates metastatic gene expression in CRC. Although further mechanistic studies are warranted, the present study provided notable genetic and phenotypic evidence of the role of in promoting cancer cell migration and invasion, offering a potential foundation for future studies into its signaling interactions and therapeutic potential. - Source: PubMed
Publication date: 2025/11/27
Alghamdi Rana AAl-Zahrani Maryam H - Laryngeal cancer is a prevalent and aggressive type of head and neck malignancy that often presents with a poor prognosis. Its high incidence and significant mortality rate pose a substantial challenge in clinical management, but the prognostic biomarkers and the mechanisms of progression are poorly understood. We sought to identify the prognostic biomarkers and their effects in the progression of laryngeal cancer. - Source: PubMed
Publication date: 2025/10/22
Huang ShaokunShan XuanSong FanWu MinLi ChaofanWang XiaohuiZhao RuipingYe Juan - Ulcerative colitis (UC) is a chronic inflammatory condition marked by immune dysfunction and disruption of the intestinal epithelial barrier, in which mast cells play a significant role through the release of inflammatory mediators. Recent advances suggest that mast cell-derived exosomes and intraluminal vesicles (MC-EXOs and MC-ILVs) may contribute to disease pathogenesis by modulating epithelial tight junction proteins, particularly members of the Claudin family. Notably, transcriptomic analyses indicate that CLDN23, a gene encoding Claudin-23, is downregulated in active UC. Exosomes are emerging as key players in intercellular communication, capable of delivering functional microRNAs and proteins that influence intestinal permeability and immune cell behaviour. This mini-review summarizes current evidence on the interaction between mast cell-derived vesicles and intestinal epithelial cells, focusing on their regulatory role in Claudin expression and immune signalling pathways. Understanding these mechanisms may inform the development of exosome-based biomarkers and therapeutic strategies for UC. - Source: PubMed
Publication date: 2025/09/10
Li Shao-HanXu Hao-MingHuang Hong-LiZhou Yong-Jian - Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue. Although genome-wide association studies (GWAS) have identified susceptibility variants, their tissue-specific regulatory impact remains poorly understood. - Source: PubMed
Publication date: 2025/08/06
Garibaldi-Ríos Asbiel FelipeRodríguez-Gutiérrez Perla GracielaGarcía-Díaz Jesús MagdielZúñiga-González Guillermo MoisésFiguera Luis EGómez-Meda Belinda ClaudiaPuebla-Pérez Ana MaríaDávalos-Rodríguez Ingrid PatriciaTorres-Mendoza Blanca MiriamGutiérrez-Hurtado Itzae AdonaiGallegos-Arreola Martha Patricia - Apigenin and sodium butyrate have been reported to help alleviate oxidative stress. This study evaluated the jejunal transcriptomic responses in ducks receiving apigenin and sodium butyrate supplementation under oxidative stress. In total, 200 healthy 300-day-old female Jinyun Ma ducks (1.53 kg ± 0.15) were randomly divided into four groups, with five replicates per group. The groups were as follows: a control group (CON): ducks were fed a basal diet with sterile saline injection; a diquat-injection (DIQ) group: ducks were fed a basal diet with diquat injection; an apigenin plus diquat group (API): ducks were fed a basal diet containing apigenin (500 mg/kg) with diquat injection; and a sodium butyrate plus diquat group (SB): ducks were fed a basal diet containing sodium butyrate (500 mg/kg) with diquat injection. The injection dose of diquat is 8 mg/kg body weight. Analysis revealed that the dietary supplementation of apigenin and sodium butyrate reduced malondialdehyde (MDA) levels and increased total antioxidant capacity (T-AOC) ( < 0.05). Compared to the DIQ group, sodium butyrate supplementation during oxidative stress elevated jejunal villus height and villus height/crypt depth ratio in ducks ( < 0.05). The study identified that some candidate genes, including solute carrier family 4 member 3 (), ADAM metallopeptidase domain 12 (), and B-cell lymphoma 2-associated-athanogene 3 (), were significantly upregulated, whereas claudin 23 () and glucose-6-phosphatase catalytic subunit 1 () were markedly downregulated in the API group in comparison with that in the DIQ group ( < 0.05). Collectively, our findings provide molecular evidence for the beneficial effects of apigenin and sodium butyrate against oxidative stress in the jejunum of ducks. - Source: PubMed
Publication date: 2025/07/11
Zhou NingSun HanxueTian YongZhang HengXian XuemeiYu HuiZhao LingyanChen YongSun MingkunZhang YiqianMeng TingLu Lizhi