CLDN7 antibody - middle region (ARP33613_P050)
- Known as:
- CLDN7 (anti-) - middle region (ARP33613_P050)
- Catalog number:
- arp33613_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CLDN7 antibody - middle region (ARP33613_P050)
Related genes to: CLDN7 antibody - middle region (ARP33613_P050)
- Gene:
- CLDN7 NIH gene
- Name:
- claudin 7
- Previous symbol:
- CEPTRL2, CPETRL2
- Synonyms:
- Hs.84359
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-19
- Date modifiied:
- 2015-09-11
Related products to: CLDN7 antibody - middle region (ARP33613_P050)
Related articles to: CLDN7 antibody - middle region (ARP33613_P050)
- Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are classified into low grade (LG), high grade (HG), and invasive carcinoma-associated (IC) groups, each requiring different clinical therapeutic strategies. Loss of planar nuclear polarity (PNP) in IPMNs is a key factor in tumor progression. We studied 29 IPMN cases (8 LG, 10 HG, and 11 IC) using targeted next-generation sequencing and immunohistochemistry to elucidate the complex molecular dynamics of PNP factors in tumor progression. We analyzed the mRNA expression of 61 PNP-related factors, including those associated with the cell membrane, epithelial-mesenchymal transition (EMT), the Hippo pathway, cytoskeletal network, and nuclear envelope, in the IPMN cases. The Kruskal-Wallis test identified 15 PNP factors (ITGB1, CLDN4, CLDN7, ANO1, TWIST1, SRSF1, LATS2, TOP2A, MAPK1, TGFBR1, PCNT, FSCN1, RHOA, CDC42, and SYNE3) with significantly higher mRNA expression in IC compared with LG and HG. Multinomial logistic regression identified three PNP factors (CLDN7, FSCN1, and TOP2A) with significantly higher mRNA expression and stronger or more frequent immunohistochemical positivity in both LG versus IC and LG versus HG comparisons. Overall, our study indicates that the molecular mechanisms underlying disturbed PNP in IPMNs are not mediated by a single pathway but involve multiple interconnected pathways. Our findings may contribute to elucidation of the molecular mechanisms regulating PNP in IPMNs, enhancing our understanding of tumor progression and contributing to more accurate pathological diagnosis. - Source: PubMed
Publication date: 2026/03/28
Tamura TakaakiMatsuzaki IbuMusangile Fidèle YambayambaTakahashi YuichiItonaga MasahiroAshida ReikoKojima FumiyoshiKitano MasayukiMurata Shin-Ichi - Breast cancer (BRCA) is a common malignant tumor in women globally and has a poor prognosis. Molecular targeted therapy is a promising way for improving the treatment of BRCA. This study aimed to identify potential biomarkers for BRCA and construct a prognostic model. - Source: PubMed
Publication date: 2026/02/12
Xia ManzhiDong ShufengCao JieWang JiaWang Chunlei - Claudin‑7 (CLDN7) is a key component of epithelial tight junctions. It plays a vital role in maintaining cell polarity, barrier integrity and paracellular transport. Abnormal CLDN7 expression is closely related to the onset and progression of various diseases. It is especially markedly associated with the growth and metastasis of multiple cancers. Additionally, dysregulated CLDN7 expression contributes to the progression of intestinal, skin and respiratory system diseases. The present review summarized the structure, expression, physiological functions, stability and regulatory mechanisms of CLDN7, emphasizing its role in tumors. The expression patterns, regulatory mechanisms, effect on malignant phenotypes and clinical significance of CLDN7 were also discussed. - Source: PubMed
Publication date: 2026/03/06
Lai XiupingYan YanSun LuLei ZiliYang Yanhong - In this exploratory pilot study, we profiled human periodontal ligament (PDL) transcriptomes during early orthodontic tooth movement (OTM). Early-stage (0-10 days) transcriptional dynamics under tension and compression remain insufficiently understood, and no dedicated user-friendly resource has been available for exploring large-scale human data. - Source: PubMed
Publication date: 2026/02/18
Zhang XiaoqiXing LuAi-Gumaei WaseemZhang XiaoqianWang QingxuanLi MinqiLong HuLai Wenli - Ovarian cancer (OC) ranks as the seventh most prevalent malignancy diagnosed in women. This work sought to delineate the hub and core genes, as well as the probable pathways implicated in the molecular pathogenesis of ovarian cancer (OC). - Source: PubMed
Publication date: 2026/02/04
Abroudi Ali ShakeriJalaeianbanayan AryanDjamali MelikaAzizi Hossein