ZNF217 antibody - middle region (ARP33555_P050)
- Known as:
- ZNF217 (anti-) - middle region (ARP33555_P050)
- Catalog number:
- arp33555_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF217 antibody - middle region (ARP33555_P050)
Related genes to: ZNF217 antibody - middle region (ARP33555_P050)
- Gene:
- ZNF217 NIH gene
- Name:
- zinc finger protein 217
- Previous symbol:
- -
- Synonyms:
- ZABC1
- Chromosome:
- 20q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-13
- Date modifiied:
- 2014-11-19
Related products to: ZNF217 antibody - middle region (ARP33555_P050)
Related articles to: ZNF217 antibody - middle region (ARP33555_P050)
- Accurate inference of absolute copy numbers beyond simple gains and losses from single-cell chromatin accessibility (scATAC-seq) data remains challenging, thereby obscuring the distinction between genetic and epigenetically driven oncogenic dependencies. Here, we present TeaCNV, a computational framework that reconstructs clonal absolute copy number profiles and tumor clonal architectures from scATAC-seq data without matched DNA baselines. Through validation both in silico and against bulk whole-genome sequencing in renal cell carcinomas, TeaCNV resolved subclonal absolute copy number profiles with less than 10% error and detected copy number variations (CNVs) with 98.6% accuracy, outperforming existing methods. Applied to six cancer types including renal, breast, pancreatic, head and neck, colorectal, and ovarian cancers, TeaCNV delineated polyclonal architectures and revealed distinct chromatin accessibility patterns driven by CNVs in key driver genes, including AKT2, ZNF217, and SOX2. By enabling absolute copy number profiling and clonal deconvolution from epigenomic assays, TeaCNV bridges critical gaps in studying oncogenic dependencies and genotype-phenotype relationships at single-cell resolution. - Source: PubMed
Wang YingDeng YuhaoLi HangYin XinbaoZhang YanruChen YurongZhang MinWang XinCao ZhizhuoZhang Shaojun - Umbilical cord mesenchymal stem cells (UCMSCs) have been shown to actively participate in diabetic foot ulcer (DFU) wound healing. The human foreskin fibroblast-1 (HFF-1) cell line is a crucial and widely used in vitro model for fundamental research on DFUs. In this study, the role of UCMSC-derived exosomal circDLGAP4 in high-glucose (HG)-stressed HFF-1 cells was clarified, in particular whether it regulates the TATA-box binding protein-associated factor 15 (TAF15)/p300/zinc finger protein 217 (ZNF217) axis to enhance cell proliferation and migration. We confirmed that UCMSC-derived exosomes that contained circDLGAP4 in abundance enhanced the proliferation and migration of HG-stressed HFF-1 cells. Under an HG environment, ZNF217 was downregulated in the HFF-1 cells, whereas its overexpression promoted the proliferation and migration of the cells, an effect facilitated by its own activation via the p300-mediated H3K27 acetylation of its gene promoter. The p300 mRNA was stabilized through interaction with TAF15, while the expression of TAF15 was upregulated through its interaction with circDLGAP4. Additionally, exosomal circDLGAP4 promoted wound healing in mice with DFUs. In conclusion, UCMSC-derived exosomal circDLGAP4 enhanced HFF-1 cell proliferation and migration under HG conditions in vitro and promoted diabetic wound healing in vivo by activating the TAF15/p300/ZNF217 axis. - Source: PubMed
Publication date: 2026/05/27
Ma Yun-LeiFu JiaZhang Yao-XueXue Han-YueLuo Yue-YueZhang Wei-ZheKuang Shao-JiaXu Jia-QinLiang Zun-Hong - The Arabidopsis thaliana (Arabidopsis) protein HAKAI-interacting zinc finger protein 1 (HIZ1) is both a transcriptional regulator and a component of the N6-methyladenosine (m6A) writer complex that methylates certain adenosines within mRNA. Unlike other components of this complex, HIZ1 is not expressed constitutively throughout the plant, is not required for m6A deposition, and, when ectopically overexpressed, results in reduced levels of m6A. However, the biological functions of HIZ1 remain unclear. Here, we generated additional HIZ1 constitutive overexpression (HIZ1 OX) lines and selected eight lines, showing varying levels of expression. These plants exhibited pleiotropic developmental defects, the severity of which correlated with expression level. However, higher levels of HIZ1 overexpression did not reduce m6A levels beyond a 25% decrease, consistent with the complete titration of methylase complex interacting partner(s). Using chromatin immunoprecipitation sequencing (ChIP-seq), we showed that HIZ1 is predominantly associated with predicted gene promoter regions and is significantly enriched on genes whose transcripts in wild-type plants are m6A modified. Our results suggest that constitutive overexpression of HIZ1 promotes vegetative growth and disrupts reproductive growth in Arabidopsis. This likely occurs both through m6A inhibition and transcriptional regulation. Thus, HIZ1 may function in an analogous fashion to the mouse zinc finger protein 217 (ZFP217, human homolog ZNF217), which acts as both a transcriptional regulator and a suppressor of the m6A methylation complex. - Source: PubMed
Publication date: 2026/05/26
Zhang MiMongan Nigel PArcher NathanFray Rupert G - Chemotherapy has significantly improved survival in breast cancer and, in the neoadjuvant setting, contributes to tumor downstaging and increased rates of breast-conserving surgery while enabling in vivo assessment of tumor biology and chemosensitivity. Pathological complete response (pCR) is a key endpoint associated with favorable outcomes; however, tumor heterogeneity highlights the need for reliable predictive biomarkers. This study evaluated the mRNA expression of 13 candidate genes in relation to molecular subtypes and pathological response to neoadjuvant chemotherapy (NAC) to identify potential predictive and prognostic markers. Pretreatment core biopsies from 92 patients receiving NAC were analyzed by quantitative RT-PCR. Molecular subtypes were determined by immunohistochemistry (ER, PR, HER2, Ki67), and pathological response was classified using the Miller-Payne scale as good (MP 4/5) or poor (MP 1-3). Multivariate logistic regression assessed associations between gene expression, subtype, and pCR. Hormone receptor-positive tumors showed significantly higher expression of , , , , , and . Significant associations with pCR were observed for , , , and . Low and expression levels were independently associated with pCR. In addition, their combined low expression was associated most strongly with breast pCR in this cohort. These findings should be interpreted as exploratory and require validation in independent cohorts. - Source: PubMed
Publication date: 2026/03/11
Baulies SoniaMolina-Vila Miguel AngelTresserra FrancescRodríguez IgnacioHurni YannickGiménez-Capitán AnaCabrera SilviaFábregas Rafael - Breast cancer remains a major health issue, with bone metastases negatively impacting patient outcomes. The biochemical and biological functions of the exon 4-splice isoform (ZNF217-ΔE4) of the oncogenic transcription factor ZNF217 have been poorly investigated. - Source: PubMed
Publication date: 2026/02/18
Fahmé PiaBouazza LamiaCroset MartineRamadan FarahCroze SéverineRiso MariapiaFerraro JustinClézardin PhilippePeyruchaud OlivierLachuer JoëlGyőrffy BalázsColeman Robert ACohen Pascale A