PIK3R3 antibody - middle region (ARP33538_T100)
- Known as:
- PIK3R3 (anti-) - middle region (ARP33538_T100)
- Catalog number:
- arp33538_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PIK3R3 antibody - middle region (ARP33538_T100)
Related genes to: PIK3R3 antibody - middle region (ARP33538_T100)
- Gene:
- PIK3R3 NIH gene
- Name:
- phosphoinositide-3-kinase regulatory subunit 3
- Previous symbol:
- -
- Synonyms:
- p55
- Chromosome:
- 1p34.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-12
- Date modifiied:
- 2015-11-17
Related products to: PIK3R3 antibody - middle region (ARP33538_T100)
Related articles to: PIK3R3 antibody - middle region (ARP33538_T100)
- B-type natriuretic peptide (BNP) is widely used to diagnose and assess heart failure prognosis. However, its effects on pathological cardiomyocyte hypertrophy and the underlying mechanisms remain largely unexplored. - Source: PubMed
Publication date: 2026/07/31
Wu ChangchunWang YaqingZhang ZixuanHe ChenFeng HaiyanSun ZhipengRen DongshengDu MengzeHuang Jian - Calorie restriction (CR) is a well-established non-genetic intervention for lifespan extension in multiple model organisms. Seasonal food shortage in cold and temperate seas may mimic CR, inducing in bivalves a response similar to that in vertebrates and thereby prolonging life expectancy. However, the relationship and the mechanism underlying the food availability and lifespan in bivalves remain largely unexplored. Two closely related scallop species the short-lived warm-water Argopecten irradians (lifespan <2 years) and the longer-lived cold-water Argopecten purpuratus (7-10 years) provide an ideal comparative system to investigate species-specific adaptive strategies. In this study, we subjected both species to CR for 30 and 56 days and performed comparative transcriptomic profiling, weighted gene co-expression network analysis (WGCNA), and physiological assays to elucidate their distinct molecular responses. Transcriptomic analysis revealed that A. purpuratus exhibited substantially more DEGs than A. irradians at both time points under CR, with both species showing downregulation of metabolic pathways but to different extents. A. irradians mounted an early nutrient-sensing response at 30 days (IGF1R, PIK3R3, INSR suppression), indicating acute sensitivity to limitation; by contrast, A. purpuratus displayed delayed FoxO activation at 56 days, along with its downstream effectors NFKBIA, CREB3L4, and SMAD4, suggesting a gradual adaptive program may link to its extended lifespan. WGCNA identified three negatively correlated modules in each species, with coral2 being the most prominent in A. irradians and darkolivegreen in A. purpuratus. The former was dominated by ciliary motility genes, whereas the latter featured coordinated repression of oxidative phosphorylation. Additionally, both species exhibited conserved suppression of mTOR/S6K growth signaling and activation of cellular maintenance programs. Collectively, these findings expand the understanding of CR-mediated longevity regulation in bivalves and provide candidate gene resources for future functional studies and breeding programs. - Source: PubMed
Publication date: 2026/08/10
Zhao YangZhang JilinLiu ChangdaWang ChunyeShao XiangXu XinWang Chunde - Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease characterized by airflow limitation, with genetic factors playing a crucial role in its pathogenesis. Effective-component compatibility of Bufei Yishen formula Ⅲ (ECC-BYF Ⅲ) has been shown to effectively ameliorate COPD symptoms; however, its underlying molecular mechanism remains elusive. - Source: PubMed
Publication date: 2026/07/20
Guan QingzhouLiu ChunleiHuang LidongLu RuilongXie YuanYue ChangyuanZhang TiantianZhang LanxiTian YangeLi Jiansheng - Following the publication of the above article, a concerned reader drew to the Editor's attention that western blot data featured in Fig. 5D were apparently the same as those featured in a different research article by the same group in the journal American Journal of Translational Research. In addition, various of the western blot data featured in Figs. 5, 6 and 7, and the cell migration and invasion assay data in Fig. 2C and D, were strikingly similar to data that were featured in other papers written by different authors at different research institutes, some of which have since been retracted, including a pair published in 2014/2015 in the journal PLoS One. Given the fact that the contentious data mentioned above had been included in articles published by other research groups in different journals before this paper was received at , the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 37: 2185‑2192, 2017; DOI: 10.3892/or.2017.5458]. - Source: PubMed
Publication date: 2026/07/31
Zhu YonggangZhao HongguangRao MinXu Songbai - We aimed to explore the critical role of PIK3R3 in pan-cancer, which to facilitate the development of more targeted prognostic markers and therapeutic strategies for these malignancies. - Source: PubMed
Publication date: 2026/07/22
Ding ZhixunLi Duandan