ZNF37A antibody - middle region (ARP33527_T100)
- Known as:
- ZNF37A (anti-) - middle region (ARP33527_T100)
- Catalog number:
- arp33527_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF37A antibody - middle region (ARP33527_T100)
Related genes to: ZNF37A antibody - middle region (ARP33527_T100)
- Gene:
- ZNF37A NIH gene
- Name:
- zinc finger protein 37A
- Previous symbol:
- -
- Synonyms:
- KOX21, ZNF37
- Chromosome:
- 10p11.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-30
- Date modifiied:
- 2016-11-16
Related products to: ZNF37A antibody - middle region (ARP33527_T100)
Related articles to: ZNF37A antibody - middle region (ARP33527_T100)
- Pork is a major source of animal protein for humans, and as living standards have improved, consumer demand has shifted from quantity to quality. Amino acid and fatty acid compositions determine the nutritional value and flavor of pork. However, the genetic mechanisms underlying variation in these parameters have not been fully elucidated. In this study, we quantified 17 amino acids and 42 fatty acids in the muscle from three crossbred pig populations, namely Yorkshire × Tibetan (YT), Yorkshire × Neijiang (YN), and Duroc × Tibetan (DT). YT and YN pigs exhibited higher amino acid concentrations, while DT pigs showed elevated fatty acid levels. Subsequently, whole-genome resequencing of 73 pigs identified 24,125,658 high-quality SNPs, among which 146 were significantly associated with fatty acid traits, leading to the identification of 19 candidate genes linked to palmitic acid (i.e., , and ), oleic acid (i.e., , and ), and total fatty acids (i.e., ). Functional annotation revealed that these candidate genes participate primarily in pathways related to lipid metabolism, glucose homeostasis, and energy balance. The identified SNPs and candidate genes provide valuable insights into the genetic architecture of the fatty acid composition in pork and may serve as molecular targets for improving meat quality through breeding. - Source: PubMed
Publication date: 2026/01/29
Tang JieLiang YanAn RuiLuo GanTao XuanLiu PengliangGu Yiren - Corticosteroids are effective anti-cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long-term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid-induced AVN in a well-characterized cohort of pediatric cancer patients. We conducted a genome-wide association study (GWAS) on 972 patients, including 108 with AVN grade ≥2 and 864 dose-matched controls. The GWAS of 6.4 million genetic markers identified four significant AVN-associated loci (P < 5 × 10): WNT7B (OR = 9.2; 95% CI, 3.8-22.0), POGK (OR = 8.4; 95% CI, 3.6-19.5), ZNF37A (OR = 6.0; 95% CI, 2.9-12.5), and a synonymous variant in FAM240C (OR = 5.0; 95% CI, 2.6-9.5). A multi-marker predictive model combining single nucleotide polymorphisms (SNPs) and clinical factors showed an area under the ROC curve (AUC) of 78.7%, outperforming SNP-only (67.8%) and clinical-only (68.4%) models. The osteogenic processes regulated by WNT7B, part of the Wnt signaling pathway, may contribute to AVN-related disrupted bone development and repair. Similarly, POGK and ZNF37A, both containing the KRAB domain, are hypothesized to affect osteoblast differentiation and skeletal development in AVN. Developing a predictive model for individual susceptibility to corticosteroid-induced AVN will enhance the monitoring and management of corticosteroid use in children with cancer. - Source: PubMed
Publication date: 2025/07/25
Cordova-Delgado MiguelScott Erika NRassekh Shahrad RLoucks Catrina MChang Wan-ChunRaack Edward JTrueman Jessica NRoss Colin J DCarleton Bruce C - The identification a signature comprising a group of genes as markers of cancer response to chemoradiotherapy would be more appropriate and effective for predicting chemoradiotherapy efficacy. This study investigated the differentially expressed genes (DEGs) related to chemoradiotherapy resistance and established a multigene expression model for predicting the sensitivity of rectal cancer to chemoradiotherapy in rectal cancer patients, elucidated the mechanism of resistance to synchronized chemoradiotherapy. The genome-wide expression profiling microarray were performed in the tissues of 81 rectal cancer patients before neoadjuvant therapy to analyze and discover DEGs related to chemoradiotherapy resistance, and the results were verified in 45 rectal cancer patients, and finally a 20-gene signature was proposed to be a predictor of chemoradiotherapy response. Molecular biology experiments revealed that zinc finger protein 37A (ZNF37A) downregulation leads to therapeutic resistance. This study identified a 20-gene signature with group of genes can help predict the response to chemoradiotherapy of rectal cancer patients. ZNF37A demonstrated a statistically significant correlation with sensitivity to chemoradiotherapy and survival in patients with LARC who underwent chemoradiotherapy. The findings revealed that ZNF37A bound to the tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) promoter region, thereby suppressing its transcriptional activity. Reduced expression of ZNF37A induces chemoradiation resistance by inhibiting apoptosis in colorectal cancer (CRC) cells. TNFRSF6B Knockdown restored the sensitivity of CRC to chemoradiotherapy. ZNF37A is an effective modulator of chemoradiotherapy response in rectal cancer. These findings elucidate the molecular mechanism underlying chemoradiotherapy resistance and provide potential applications for individualized clinical therapy. - Source: PubMed
Publication date: 2024/11/20
Huang YingJin JingRen NingxinChen HongxiaQiao YanZou ShuangmeiWang XinZheng LinlinLi Ye-XiongTan WenLin Dongxin - Circular RNA is emerging functional molecule for glioblastoma. However, the function and regulatory of circular RNA (circRNA) remains unclear. In this study, the circRNA sequencing and array data of glioblastoma were analyzed by multiple bioinformatics methods to establish a potential molecular sponge mechanism regulation network. - Source: PubMed
Zhao LiwenZhang PengfeiNan YangRen BingchengMa HaiwenXie JiapengHuang Qiang - Poorly differentiated colorectal cancer (CRC) is characterized by aggressive invasion and stromal fibroblast activation, which results in rapid progression and poor therapeutic consequences. However, the regulatory mechanism involved remains unclear. Here, we showed that ZNF37A, a member of KRAB-ZFP family, was upregulated in poorly differentiated CRCs and associated with tumor metastasis. ZNF37A enhanced the metastatic potential of multiple CRC cell lines and promoted distant metastasis in an orthotopic CRC model. Further investigation attributed the ZNF37A-exacerbated metastasis to increased extracellular TGF-β and the consequent activation of cancer-associated fibroblasts (CAFs) in tumor microenvironment (TME). Mechanistically, ZNF37A formed a complex with KAP1 and bound to the promoter of THSD4, a TME modulator, to suppress its transcription, which is required for ZNF37A-mediated TGF-β activation and CRC metastasis. Collectively, our study indicates that ZNF37A promotes TGF-β signaling in CRC cells and activates CAFs by transcriptionally repressing THSD4 to drive CRC metastasis, implicating ZNF37A as a potential biomarker for CRC differentiation and progression. - Source: PubMed
Publication date: 2021/04/19
Liu JiayangHuang ZhaoChen Hai-NingQin SiyuanChen YanJiang JingwenZhang ZheLuo MaochaoYe QinXie NaZhou Zong-GuangWei YuquanXie KeHuang Canhua