WNT8B antibody - middle region (ARP33491_T100)
- Known as:
- WNT8B (anti-) - middle region (ARP33491_T100)
- Catalog number:
- arp33491_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- WNT8B antibody - middle region (ARP33491_T100)
Related genes to: WNT8B antibody - middle region (ARP33491_T100)
- Gene:
- WNT8B NIH gene
- Name:
- Wnt family member 8B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-01
- Date modifiied:
- 2016-10-05
Related products to: WNT8B antibody - middle region (ARP33491_T100)
Related articles to: WNT8B antibody - middle region (ARP33491_T100)
- Hepatolithiasis (HL) is a prevalent condition in hepatobiliary surgery, often complicated by hepatatrophia. This study aimed to identify gene mutations in HL specimens with hepatatrophia and construct a mutation landscape using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/04/09
Tang DanGu XuanyuLiu DanYang JialiZhao Lijin - In Atlantic halibut () aquaculture, egg and larval quality remain major bottlenecks. Most transcriptomic and proteomic studies compare freshly fertilized eggs of good versus poor quality, assuming early molecular differences explain hatching success. However, many lethal phenotypes arise only after the mid-blastula transition (MBT), suggesting that early comparisons may overlook key developmental processes. - Source: PubMed
Publication date: 2025/12/08
Niepagen NilsBertolini FrancescaBerg LeifTomkiewicz JonnaKjørsvik Elin - - Source: PubMed
Publication date: 2025/10/22
Gao YuwenLuo YangGao YingxiaChen XingyuZhang YuZhou YuanXu BeileiYao XuLiu Xiaochun - : Low birth weight (LBW) is correlated with gut microbiota dysbiosis and intestinal barrier function disruption, increasing susceptibility to enteric diseases. These alterations underscore the critical need to identify key regulators of gut homeostasis, among which bile acids are increasingly recognized as pivotal for barrier integrity, microbial ecology, and host metabolism. : Eight pairs of LBW (the initial BW was 0.850 ± 0.053 kg) and normal-birth-weight (NBW; 1.488 ± 0.083 kg) piglets were compared to evaluate cecal morphology and bile acid profiles. Subsequently, sixteen LBW piglets and eight NBW piglets were allocated into three groups: NBW (1.563 ± 0.052 kg), LBW control (LBW-CON; 0.950 ± 0.120 kg), and LBW with bile acid supplementation (LBW-bile powder; 0.925 ± 0.116 kg). Piglets in the LBW-bile powder group received 25 mg/kg BW of bile powder (hyodeoxycholic acid-enriched) by daily oral gavage for 14 days. : LBW piglets exhibited retarded cecal development and lower abundance of hyocholic acid species ( = 0.006). Importantly, bile powder supplementation significantly improved cecal length ( = 0.009) and mucosal thickness ( = 0.020) compared with LBW-CON piglets. Microbial analysis showed that the microbial dysbiosis index was restored to near-normal levels. Transcriptomic analysis revealed impaired extracellular matrix structure and mucus secretion in LBW piglets. Notably, bile powder supplementation markedly upregulated the protein expression of WNT8B ( < 0.001) and the bile acid receptors (i.e., GPBAR1 and FXR), alongside enhanced tight junctions and the goblet cell marker mucin-2 expression ( < 0.05). : These findings suggest that specific bile acid supplementation improves gut barrier function and partially supports cecal development in LBW piglets. - Source: PubMed
Publication date: 2025/10/30
Yin ChangLiu XuanFang WeiMeng QingshiFeng XiaohuiZhang WeidongDang GuoqiZhong RuqingChen LiangWang ZirongZhang Hongfu - The () gene is a chromatin regulator involved in transcriptional activation and repression. While Asxl1 plays a crucial role in various organ development, its role in ocular development remains unclear. Here, we analyzed knockout (KO) mice and observed disrupted optic cup formation at embryonic day 10.5 (E10.5). RNA-seq of the E10.5 optic cup revealed dysregulation of Wnt signaling and early eye development genes. In further investigation using isolated cell from E10.5 retinal region, neuroepithelial stem cells from KO embryos exhibited impaired proliferation and spheroid formation. To elucidate the transcriptional mechanism by Asxl1 in optic cup formation, biochemical assays demonstrated that Asxl1 binds the LIM domain of Lhx2, facilitating repression of Wnt1, Wnt2, and Wnt8b. Following ChIP analysis showed that the gain of function of Asxl1 increased repressive histone marks (H3K27me3, H3K9me3) and reduced active marks (H3K4me3) at Lhx2-binding motifs within the cis-regulatory regions of canonical Wnt ligand genes. These findings establish Asxl1 as a key epigenetic regulator of optic cup development by modulating Lhx2-mediated Wnt signaling, providing insights into congenital eye disorders. - Source: PubMed
Publication date: 2025/08/04
Moon SeungtaeKim NackhyuongKim A-ReumMoon Kyeong HwanKim Jin WooUm Soo-Jong