WNT8B antibody - middle region (ARP33491_T100)
- Known as:
- WNT8B (anti-) - middle region (ARP33491_T100)
- Catalog number:
- arp33491_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- WNT8B antibody - middle region (ARP33491_T100)
Related genes to: WNT8B antibody - middle region (ARP33491_T100)
- Gene:
- WNT8B NIH gene
- Name:
- Wnt family member 8B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-01
- Date modifiied:
- 2016-10-05
Related products to: WNT8B antibody - middle region (ARP33491_T100)
Related articles to: WNT8B antibody - middle region (ARP33491_T100)
- Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder characterized by reproductive dysfunction, oxidative stress, and metabolic abnormalities. The present study investigated the therapeutic efficacy of a hydroalcoholic extract of Anchusa strigosa in a letrozole-induced PCOS rat model and explored its effects on ovarian Wnt signaling. Female Wistar rats (n = 36) were divided into normal control, PCOS control, A. strigosa low-dose (100 mg/kg), A. strigosa high-dose (250 mg/kg), and metformin (50 mg/kg) groups. Phytochemical profiling by FTIR and GC-MS identified 114 bioactive compounds enriched with phenolic, thiol, and isothiocyanate functional groups. Letrozole administration significantly increased body weight from 174.33 ± 1.80 g to 249.66 ± 1.66 g and elevated malondialdehyde levels from 45.42 ± 1.92 to 70.20 ± 1.51 while reducing superoxide dismutase from 28.97 ± 0.55 to 16.82 ± 0.59 and glutathione from 4.09 ± 0.07 to 1.83 ± 0.10 compared with normal controls. Treatment with A. strigosa, particularly at 250 mg/kg, markedly restored estrous cyclicity, reduced final body weight to 225.27 ± 0.57 g, decreased malondialdehyde to 60.90 ± 0.48, improved superoxide dismutase to 22.57 ± 0.27 and glutathione to 3.22 ± 0.09, normalized reproductive hormones and lipid profiles, restored ovarian morphology, and significantly upregulated ovarian Wnt7a and Wnt8b gene and protein expression. Although metformin produced slightly superior therapeutic effects, A. strigosa demonstrated comparable efficacy across most reproductive and metabolic parameters, highlighting its multi-target pharmacological potential. These findings suggest that A. strigosa represents a promising phytotherapeutic candidate for PCOS management. Future studies should focus on isolation of its active constituents, elucidation of the molecular mechanisms underlying Wnt pathway modulation, long-term safety evaluation, and well-designed clinical trials to establish its translational applicability in human PCOS. - Source: PubMed
Publication date: 2026/08/24
Sheikh Wajid MohammadJan JasmeenaWani Atif KhurshidShafi MajidHussain IshraqJadhav IndraniBashir Showkeen Muzamil - The ketogenic diet (KD) is widely used in disease management and healthy populations, but its long-term physiological safety remains unclear. While KD protects against kidney injury in models, its effects on healthy renal tissue are poorly understood. - Source: PubMed
Publication date: 2026/06/27
Zhang YuzhanGuan KexinGuo ShuxianGao JingliBai XiaoYang YifanWang HaoXiaoxuan NingSun Shiren - Circular RNAs (circRNAs) exhibit significant sex- and development stage-specific expression patterns in the gonads of various fish species, yet their functions and regulatory mechanisms in male reproductive development remain largely unexplored in crucian carp (). In this study, we characterized the expression features and biological functions of circSPEF2, a circular RNA derived from the reproduction-related gene . Our results showed that circSPEF2 expression was markedly elevated in mature testes and progressively upregulated during gonadal maturation. Functional studies suggested that circSPEF2 likely does not act through a ceRNA-dependent mechanism. Transcriptome sequencing following circSPEF2 overexpression identified 45 upregulated and 70 downregulated differentially expressed genes, with GO and KEGG enrichment analyses revealing significant alterations in multiple gonadal development-related genes and signaling pathways. Subsequent siRNA-mediated knockdown of circSPEF2, combined with qRT-PCR validation, confirmed that circSPEF2 positively regulates the expression of genes associated with cell maturation and differentiation, including , , and , while concurrently suppressing that of proliferation- and apoptosis-related genes such as , , and . Furthermore, RNA pull-down combined with mass spectrometry identified three candidate circSPEF2-binding proteins, namely, hnRNP A/B, SRSF2, and CFAP263. Collectively, these findings indicate that circSPEF2 plays an important role in male gonadal development in fish and provide new insights into the post-transcriptional regulatory mechanisms underlying vertebrate male reproduction. - Source: PubMed
Publication date: 2026/04/23
Gou FangGao YanmeiWang RuiZhong DongmeiYang RongLiu Shaojun - Hepatolithiasis (HL) is a prevalent condition in hepatobiliary surgery, often complicated by hepatatrophia. This study aimed to identify gene mutations in HL specimens with hepatatrophia and construct a mutation landscape using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/04/09
Tang DanGu XuanyuLiu DanYang JialiZhao Lijin - In Atlantic halibut () aquaculture, egg and larval quality remain major bottlenecks. Most transcriptomic and proteomic studies compare freshly fertilized eggs of good versus poor quality, assuming early molecular differences explain hatching success. However, many lethal phenotypes arise only after the mid-blastula transition (MBT), suggesting that early comparisons may overlook key developmental processes. - Source: PubMed
Publication date: 2025/12/08
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