SUPT6H antibody - N-terminal region (ARP33387_P050)
- Known as:
- SUPT6H (anti-) - N-terminal region (ARP33387_P050)
- Catalog number:
- arp33387_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SUPT6H antibody - N-terminal region (ARP33387_P050)
Related genes to: SUPT6H antibody - N-terminal region (ARP33387_P050)
- Gene:
- SUPT6H NIH gene
- Name:
- SPT6 homolog, histone chaperone and transcription elongation factor
- Previous symbol:
- -
- Synonyms:
- KIAA0162, SPT6H
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-04
- Date modifiied:
- 2019-02-01
Related products to: SUPT6H antibody - N-terminal region (ARP33387_P050)
Related articles to: SUPT6H antibody - N-terminal region (ARP33387_P050)
- Hyperlipidemia is a potential risk factor for aortic dissection (AD), a severe cardiovascular emergency with high mortality. However, the common molecular mechanisms linking these 2 conditions remain poorly understood. This study aimed to identify common hub genes and elucidate their regulatory mechanisms in both hyperlipidemia and AD. - Source: PubMed
Publication date: 2026/03/21
Wang MengZhang KaiChang ChaoBai YunpengChen TongyunZhao FengChen Qingliang - Genetic variants affecting the RNA polymerase II complex have been associated with various neurodevelopmental disorders (NDDs). SUPT6H, an RNA polymerase II-associated elongation factor and a histone chaperone, plays a critical role in transcriptional regulation. However, the contribution of SUPT6H variants to human NDDs and the phenotypic consequences of its loss-of-function in vivo remain unexplored. Here, we analyzed 18 published sporadic single-nucleotide variants (SNVs) of SUPT6H associated with human developmental disorders. Molecular modeling suggests that these variants are likely deleterious, leading to loss of function. Consistent with this, homozygous or heterozygous Supt6 null mice exhibit embryonic lethality, underscoring its essential role during development. To investigate the postnatal consequences of Supt6 deficiency, we generated conditional Supt6 knockout (KO) mice with targeted deletion in parvalbumin-expressing GABAergic interneurons (cKO). Homozygous Supt6 cKO mice displayed motor defects and behavioral seizures, whereas heterozygous counterparts exhibited behavioral phenotypes relevant to neuropsychiatric disorders despite normal motor activity. Notably, both heterozygous and homozygous Supt6 cKO mice showed a significant reduction in parvalbumin-expressing neurons compared to wild-type controls. These findings establish a direct link between Supt6 loss-of-function and neurodevelopmental phenotypes, highlighting its critical role in maintaining interneuron populations and neural circuit integrity. Altogether, our results suggest that deleterious SUPT6H variants may contribute to the etiology of NDDs, providing valuable insights into its function and potential as a therapeutic target. - Source: PubMed
Publication date: 2026/03/19
Carabelli BrunoKim Hyung-GooKu BonsuBerdasco ClaraJeong Yu YoungLai ThoJang Mi-HyeonBoison DetlevKim Yong - Platinum-based chemotherapy resistance is one of the main contributors to the mortality of Ovarian Cancer (OC). It is believed that sensitive biomarkers for identifying the population that is platinum-resistant are urgently needed. This study aims to develop a platinum-resistance gene-based signature to predict OC patients' responses to platinum drugs as well as survival outcomes. - Source: PubMed
Lin JieCai XintongLiu LinyingLi AnyangHuang HuaqingFu YixinDai ZhisenSun Yang - Comprehensively mapping the hierarchical structure of breast cancer protein communities and identifying potential biomarkers from them is a promising way for breast cancer research. Existing approaches are subjective and fail to take information from protein sequences into consideration. Deep learning can automatically learn features from protein sequences and protein-protein interactions for hierarchical clustering. - Source: PubMed
Publication date: 2025/01/21
Zhang XiaoLiu Qian - Transcription elongation requires elaborate coordination between the transcriptional machinery and chromatin regulatory factors to successfully produce RNA while preserving the epigenetic landscape. Recent structural and genomic studies have highlighted that suppressor of Ty 6 (Spt6), a conserved histone chaperone and transcription elongation factor, sits at the crux of the transcription elongation process. Other recent studies have revealed that Spt6 also promotes DNA replication and genome integrity. Here, we review recent studies of Spt6 that have provided new insights into the mechanisms by which Spt6 controls transcription and have revealed the breadth of Spt6 functions in eukaryotic cells. - Source: PubMed
Publication date: 2023/07/20
Miller Catherine L WWarner James LWinston Fred