STAT5B antibody - N-terminal region (ARP33379_P050)
- Known as:
- STAT5B (anti-) - N-terminal region (ARP33379_P050)
- Catalog number:
- arp33379_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- STAT5B antibody - N-terminal region (ARP33379_P050)
Related genes to: STAT5B antibody - N-terminal region (ARP33379_P050)
- Gene:
- STAT5B NIH gene
- Name:
- signal transducer and activator of transcription 5B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-01-28
- Date modifiied:
- 2019-04-23
Related products to: STAT5B antibody - N-terminal region (ARP33379_P050)
Related articles to: STAT5B antibody - N-terminal region (ARP33379_P050)
- - Source: PubMed
Publication date: 2026/04/16
Aung Myint Myat KhineSchönefeldt SusannPfalz-Kraupp SophieWais TamaraSuske TobiasZahma SafiaFranz StefanMüllebner AndreaFeurstein GabrielaWagner ChristinaEder ThomasPemovska TeaAgreiter ChristianePichler AlexanderStaber Philipp BHofer MartinSteinborn RalfStrohmer Svenja-VerenaSimonitsch-Klupp IngridBauer MarcusWilfer AndreasWeber ThomasPotdar SwapnilAittokallio TeroJungherz DennisMüller Tony AList JuliaGotthardt DagmarGrebien FlorianBekiaris VasileiosHerling MarcoMoriggl RichardNeubauer Heidi A - Selective inhibition of the transcription factor STAT5b is challenging owing to the high degree of similarity to the family member STAT5a. We recently reported catechol bisphosphates as selective inhibitors of STAT5b, with Stafib-2-CR as the most potent selective STAT5b inhibitor reported to date. Here, we describe the design and synthesis of fusion molecules between Stafib-2-CR and a ligand of the E3 ligase cereblon in an effort toward STAT5b-selective proteolysis-targeting chimeras (PROTACs). The fusion molecules retain their activity against STAT5b in competitive fluorescence polarization assays, and the most potent compound is equally active against STAT5b as Stafib-2-CR, indicating that the choice of exit vector and linker is suitable for binding to STAT5b. However, conversion of the most potent fusion molecule into a cell-permeable prodrug turned out to be difficult, pointing toward the challenges of combining prodrug strategies with PROTAC technology. - Source: PubMed
Münzel TheresaSeidenstücker Karl ChristianProtzel ChristophBerg AngelaBerg Thorsten - Pheromones are key modulators of reproductive behavior in fish, and certain odorant receptors (ORs) expressed in the olfactory epithelium act as receptors for sex pheromones. The northern snakehead (Channa argus) exhibits distinctive parental care behaviors, such as nest construction and brood guarding. It is likely that hormonal regulation during the breeding season upregulates the expression of olfactory receptors, thereby enhancing the sensitivity of C. argus to pheromones released by the opposite sex and ultimately promoting the initiation of reproductive behaviors. A total of 256 functional OR genes were identified from the C. argus genome, and these were distributed across four chromosomes. Transcriptome sequencing of whole-brain and olfactory rosette tissues from males during and after the breeding season showed a marked upregulation of the olfactory receptor gene caor67 in the olfactory rosettes, as well as increased expression of prolactin (PRL) in the brain. The open reading frames (ORFs) of caor67, prl, prlra, prlrb, stat5a, and stat5b from northern snakehead were cloned and characterized. The expression of caor67 is highest in the olfactory rosettes. During the breeding season, the expression of caor67 in the male olfactory rosettes is significantly higher than in females. prl expression is relatively high in the pituitary, while prlra shows the highest expression in the gills, followed by the olfactory rosettes. prlrb has the highest expression in the olfactory rosettes, followed by the gills and kidney. In situ hybridization results show that the mRNA of caor67, prlra, and prlrb is expressed in the sensory epithelium of the C. argus olfactory rosettes, with expression detected in both ciliated and microvillous olfactory receptor neurons (ORNs). Co-localization of caor67 with prlra and prlrb was observed in the ORNs of the olfactory rosettes. Recombinant C. argus PRL (rPRL) was expressed and purified, and functional assays confirmed that it interacts with both PRLRa and PRLRb to enhance phosphorylated STAT5 (pSTAT5) activity. Overexpression of PRLRa/PRLRb or STAT5a/STAT5b significantly increased caor67 promoter-driven luciferase activity in vitro. Treatment with the JAK2 inhibitor TG101348, which blocks the JAK2-STAT5 signaling pathway, significantly reduced luciferase activity, indicating that PRL regulates the transcription of caor67 via the PRLR-JAK2-STAT5 signaling pathway. - Source: PubMed
Publication date: 2026/04/13
Jiang TianyuZuo ChenpengLyu LikangWang XiaojieSun DongleiJing XiaoYang XinlinQi Xin - Around 15-50% of patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) experience primary and secondary resistance to immune checkpoint inhibitors (ICI). We previously described three transcriptomic clusters (A, B, C) linked to progression-free survival (PFS), with cluster A ("Stromal - Proliferation) associated with the shortest PFS. Here we combine gene signature and mucinous phenotype to predict the benefit from anti-CTLA-4 plus anti-PD-1. - Source: PubMed
Publication date: 2026/04/05
Ambrosini MargheritaGallois ClaireGandini AnnaliceLecanu AurélieAlouani EmilyPietrantonio FilippoBergamo FrancescaCremolini ChiaraMazard ThibaultTougeron DavidGuimbaud RosineLonardi SaraSelves JanickMouillet-Richard SophieEmile Jean-FrancoisTaieb JulienLaurent-Puig Pierre - Plasma cell myeloma is a heterogeneous hematologic malignancy characterized by clonal expansion of plasma cells. While RAS-MAPK pathway mutations are known high-risk features, the clinical relevance of STAT3/STAT5 mutations remains unclear. - Source: PubMed
Publication date: 2026/04/08
Ye Matthew TZuo ZhuangCalin StelianaYang YalingYou M James