SATB1 antibody - C-terminal region (ARP33362_P050)
- Known as:
- SATB1 (anti-) - C-terminal region (ARP33362_P050)
- Catalog number:
- arp33362_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SATB1 antibody - C-terminal region (ARP33362_P050)
Related genes to: SATB1 antibody - C-terminal region (ARP33362_P050)
- Gene:
- SATB1 NIH gene
- Name:
- SATB homeobox 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-03
- Date modifiied:
- 2015-10-08
Related products to: SATB1 antibody - C-terminal region (ARP33362_P050)
Related articles to: SATB1 antibody - C-terminal region (ARP33362_P050)
- The transcription factor Orthopedia (Otp) plays a key role in neuronal differentiation, regional specification, and long-term maintenance of neuronal identity across vertebrates. Although Otp expression is widely used as a landmark for hypothalamic regionalization, its distribution in bony fishes has remained poorly characterized. To assess the evolutionary conservation of Otp expression, we analyzed its immunohistochemical distribution in the central nervous system of representative species from all major clades of bony fishes: cladistians, chondrosteans, holosteans, teleosts, and lungfish. To refine anatomical localization and evaluate potential cellular coexpression, we additionally examined markers including calbindin, tyrosine hydroxylase (TH), and the transcription factors Islet-1, Pax7, and Satb1/2. Otp-immunoreactive neurons were consistently observed in the medial amygdala, preoptic area, paraventricular region, all basal hypothalamic domains except the mamillary region, as well as in a population in alar rhombomere 1, the dorsal interpeduncular nucleus, central gray, reticular formation, and the dorsal horn of the spinal cord. Notably, Otp-positive cells were detected in the posterior tubercle only in actinopterygian fishes, in contrast to lungfish. Overall, this Otp expression pattern is highly conserved in relation to that reported in cartilaginous fishes and tetrapods. This study closes a major phylogenetic gap and demonstrates that the brain-wide expression pattern of Otp is largely conserved across vertebrates, supporting its fundamental and ancient role in neuronal differentiation and cell-type specification in forebrain and hindbrain. - Source: PubMed
Lozano DanielChinarro AdriánMoreno NereaLópez Jesús M - Adaptation is one of the key processes of animal domestication, environmental pressures will leave footprints in the genome. Geese are widely distributed across multiple geographical conditions with distinct adaptations. However, few reports have focused on the environmental adaptability of geese. Moreover, the key environmental drivers that trigger local adaptation and its genetic mechanisms are still unknown. To this end, 35 agro-climatic variables of 257 geese from 14 Chinese breeds were obtained, the key environmental drivers and its genetic mechanism were elucidated by combining the genome data. - Source: PubMed
Publication date: 2026/05/30
Zhou XiaoliXia JunliangChen WeidingZou JiajiaChen JiahuiZhang Xiquan - Special AT-rich sequence binding protein 1 (Satb1) is a critical chromatin organizer that globally regulates the T lymphocyte transcriptome. While its influence on primary T cell development is well documented, defining its specific function in mature peripheral T cells has been complicated by the developmental defects inherent to early-stage deletion models. To bypass these limitations, we utilized a Thpok-cre conditional knockout system to delete Satb1 specifically within mature CD4 single-positive thymocytes. We demonstrate that the ablation of Satb1 results in the spontaneous emergence of an atypical CD25FoxP3 population from naïve peripheral CD4 T cells. This aberrant de-repression of Foxp3 occurs independently of TGFβ signaling and is fundamentally driven by alterations in DNA methylation, requiring the activity of the TET2 and TET3 demethylases. Furthermore, we show that this Satb1-deficient Foxp3 expression is unstable during in vitro activation and is insufficient to confer full regulatory T cell (Treg) functionality. Collectively, our findings reveal a critical requirement for Satb1 in enforcing the lineage stability and functional fitness of conventional CD4 T cells by maintaining the epigenetic silencing of Foxp3, providing vital insights into T cell homeostasis. - Source: PubMed
Publication date: 2026/05/25
Seo WooseokZou ChengchengNair KrutulaKoseki HaruhikoKohwi-Shigematsu TerumiNishikawa HiroyoshiTaniuchi Ichiro - As a global chromatin organizer, SATB1 is increasingly implicated in neurodevelopmental disorders (NDDs). This study aims to delineate the clinical and molecular characteristics of a novel de novo variant in a patient presenting with epilepsy-dominant NDDs phenotypes. - Source: PubMed
Publication date: 2026/05/15
Xu MingchaoZhang RuiFan ShiqiSun MiaoZhang Xue - Glioma patients with type 2 diabetes show heterogeneous clinical outcomes, yet the underlying immunogenomic connections remain poorly defined. We aimed to identify shared peripheral immune transcriptomic signatures linking glioma (GBM/LGG) and T2D. Using an integrated systems biology framework combining single-cell and bulk RNA-seq, gene co‑expression networks, and transcription factor-regulatory networks, we characterized convergent transcriptomic and regulatory alterations across the two conditions. Functional bioinformatic analyses and qPCR validation further examined key candidate markers. A set of shared immune-related genes and their regulators was identified between glioma subtypes (GBM and LGG) and T2D, among which VCAN, SATB1, and CEBPD emerged as top candidates. These markers were associated with inflammatory processes and monocyte trafficking signatures. Notably, VCAN emerged as a consistently significant marker in both GBM and T2D across multiple bioinformatic analyses and qPCR validation. Overall, this study highlights candidate immunogenomic regulators linking peripheral immune alterations in glioma and T2D and provides a framework for future mechanistic studies on metabolic-immune interactions in cancers. - Source: PubMed
Publication date: 2026/05/25
Tavallaei SaraDehghanian FaribaSaboori Masih