DMRTA1 antibody - middle region (ARP33237_P050)
- Known as:
- DMRTA1 (anti-) - middle region (ARP33237_P050)
- Catalog number:
- arp33237_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- DMRTA1 antibody - middle region (ARP33237_P050)
Related genes to: DMRTA1 antibody - middle region (ARP33237_P050)
- Gene:
- DMRTA1 NIH gene
- Name:
- DMRT like family A1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-24
- Date modifiied:
- 2016-01-19
Related products to: DMRTA1 antibody - middle region (ARP33237_P050)
Related articles to: DMRTA1 antibody - middle region (ARP33237_P050)
- The generation and function of effector and memory CD8+ T cells are crucial for effective immune responses and long-term immunity. Using gene expression analysis, we found that doublesex- and mab-3-related transcription factor like family A1 (Dmrta1), a member of the DMRT family of transcription factors, is highly expressed in activated and memory CD8+ T cells. In this study, we investigated the role of Dmrta1 in the activation and differentiation of CD8+ T cells. The Dmrta1-deficient (Dmrta1-KO) mice showed an equivalent number of thymic and splenic T cells compared with wild-type mice. Dmrta1 deficiency in T cells resulted in impaired early activation of CD8+ but not CD4+ T cells and reduced expression of granzyme B in CD8+ T cells following influenza virus infection. Although virus-specific CD8+ T cell numbers and cytotoxicity in the lung were comparable between wild-type and Dmrta1-deficient mice during primary infection, Dmrta1-KO mice exhibited a transient accumulation of virus-specific CD8+ T cells in the spleen with reduced cytotoxic activity. Upon secondary challenge, memory CD8+ T cells from Dmrta1-KO mice showed persistent defects in granzyme B expression and cytotoxic function. These findings demonstrate that Dmrta1 modulates the early activation of naïve CD8+ T cells and supports the cytotoxic functionality of both effector and memory CD8+ T cells, particularly in secondary lymphoid organs, with significant implications for antiviral immunity. - Source: PubMed
Kondo HiroyukiOtsuka KunihiroMorimoto JunkoArimochi HidekiTsukumo Shin-IchiYasutomo Koji - Plectropomus leopardus is a hermaphrodite fish with a unique pattern of gonadal development. However, the molecular mechanism of sexual differentiation in this species remains unclear. The Doublesex and Mab-3 related transcription factor (dmrt) gene family are known to play a crucial role in gonad differentiation and development. Notably, systematic investigations into the composition and function of the dmrt gene family in this hermaphrodite fish remain conspicuously lacking. - Source: PubMed
Publication date: 2025/10/29
Ding HuiLi PeiyuWang JingwenYin ChenlinWu JiayiLi JiahangGuo QingranBao ZhenminWang BoHu Jingjie - Solid-tubulocystic variant of intrahepatic cholangiocarcinoma (ST-iCCA) is newly described entity characterized by two distinct histologic growth patterns: (1) solid sheets of tumor cells with focal necrosis giving pseudopapillary appearance and (2) tubular or pseudoglandular structures containing pink, colloid-like material. Tumor cells are inhibin-positive and harbor NIPBL::NACC1 fusion gene. To date, only 28 cases of ST-iCCA have been documented. While prior molecular studies provided insights into ST-iCCA, genetic profiles of individual histologic components have not been explored. This study presents first transcriptomic analysis comparing the solid/pseudopapillary and pseudoglandular components of ST-iCCA. Two cases of histologically confirmed ST-iCCA were identified for RNA sequencing which was performed on solid/pseudopapillary component, pseudoglandular component, and normal tissue. Analysis revealed distinct gene expression profiles for each pattern. Solid/pseudopapillary component uniquely overexpressed DMRTA1, NEXMIF, PRDM6, SORCS3, and NALF, while pseudoglandular component exhibited unique overexpression of HRG, ITIH3, TAT, APOA2, CP, ALDOB, CPS1, F2, KHG1, SERPINC1, HPX, C9, ADGRF1, MUC21, SAA2, SPRR2A, SAA1, FGL1, CFHR1, and LBP. These findings establish unique gene signatures for these variants of ST-iCCA, providing potential biomarkers for differential diagnosis, prognosis and targeted therapy. The distinct genetic profiles may also uncover novel therapeutic targets to address the aggressive nature of ST-iCCA. - Source: PubMed
Publication date: 2025/04/23
Bajpai PrachiGhandour FatmeJain EktaMemon RaimaPatel Chirag RKarthikeyan Santhosh KumarJagadesan SankarasubramanianGuda BabuAfaq FarrukhElkholy AmrVarambally SooryanarayanaManne UpenderDiffalha Sameer Al - Doublesex and Mab-3 (DMRT) gene family is a diverse group of transcriptional factors crucially involved in sex differentiation and biological processes such as body growth and differentiation in vertebrates. In this study, we analyzed DMRT genes structural characterization and physiochemical properties, and elucidated their functional role as a ligand of different gonadal receptors including androgen (AR), estrogen β (ER-β), estrogen γ (ER-γ), and progesterone (PR). All six genes of the DMRT gene family in grass carp (Ctenopharyngodon Idella Valenciennes, 1844) exhibited an acidic nature. These DMRT genes are primarily localized in the nucleus, where they play a role in DNA binding via doublesex DNA binding motif. All the DMRT gene pairs are under strong purifying selection with two segmental duplications envisaged about 18.30 (DMRT3a/DMRTA2) and 24.90 (DMRT2b/DMRT2a) million years ago (MYA). Recombination analysis revealed six potential recombinant breakpoints posing substantial evolutionary pressure for diverse cellular functioning of DMRT isoforms. Moreover, the DMRTA1 protein had a highest binding affinity of - 270.42 and - 267.16 for androgen receptors (AR) and progesterone receptors (PR), whereas, for estrogen receptors ER-β and ER-γ, the maximum binding affinity was observed with DMRT2a and DMRT2b proteins showing a docking score of - 254.22 and - 261.71, respectively. First time we studied the binding scores and interface residues of the DMRT genes as a ligand of gonadal receptors that play a crucial role in fish growth, sex development and differentiation, and spermatogenesis and oocyte maturation. The present study provides a molecular basis for DMRT genes in grass carp that may serve as a reference for in-depth phylogenomic study in other species. - Source: PubMed
Publication date: 2024/11/28
Parveen ShakeelaKhan Muhammad FarhanSultana MehwishRehman Saif UrShafique Laiba - Tibetan pigs are indigenous to the Qinghai-Tibet Plateau and have been the subject of extensive genomic research primarily focused on their adaptation to high altitudes. However, genetic modifications associated with their response to low-altitude acclimation have not been thoroughly explored. To investigate the genetic basis underlying the low-altitude acclimation of Tibetan pigs, we generated and analyzed genotyping data of Tibetan pigs that inhabit high-altitude regions (average altitude 4000 m) and Tibetan pigs that have inhabited nearby low-altitude regions (average altitude 500 m) for approximately 20 generations. We found that the highland and lowland Tibetan pigs have distinguishable genotype and phenotype variations. We identified 46 and 126 potentially selected SNPs associated with 29 and 56 candidate genes in highland and lowland Tibetan pigs, respectively. Candidate genes in the highland Tibetan pigs were involved in immune response ( and ) and radiation (), whereas candidate genes in the lowland Tibetan pigs were related to reproduction (, , and ), growth and development (, , and ), and blood pressure regulation (). These findings will help to understand the mechanisms of environmental adaptation in Tibetan pigs and offer valuable information into the genetic improvement of Tibetan pigs pertaining to low-altitude acclimation and economic traits. - Source: PubMed
Publication date: 2024/02/19
Liu PengliangLiang YanLi LiLv XuebinHe ZhipingGu Yiren