BACH2 antibody - middle region (ARP33233_P050)
- Known as:
- BACH2 (anti-) - middle region (ARP33233_P050)
- Catalog number:
- arp33233_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- BACH2 antibody - middle region (ARP33233_P050)
Related genes to: BACH2 antibody - middle region (ARP33233_P050)
- Gene:
- BACH2 NIH gene
- Name:
- BTB domain and CNC homolog 2
- Previous symbol:
- -
- Synonyms:
- BTBD25
- Chromosome:
- 6q15
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-01-28
Related products to: BACH2 antibody - middle region (ARP33233_P050)
Related articles to: BACH2 antibody - middle region (ARP33233_P050)
- Rotator cuff injuries often lead to impaired shoulder function, and tendon-bone healing remains challenging due to the complex structure of the enthesis and persistent remodeling-associated pro-inflammatory signaling. Low-intensity pulsed ultrasound (LIPUS) and mild hyperthermia (MH) have shown potential in tissue repair, but the molecular mechanisms underlying their combined effects are unclear. - Source: PubMed
Publication date: 2026/08/01
Xue XialiLin XingzuanGao AofeiKuati AmilaFu HaoCui GuoqingXu BingbingSong Qingfa - A significant proportion of gastric diffuse large B-cell lymphoma with mucosa-associated lymphoid tissue [DLBCL(MALT)] and without MALT ('pure' DLBCL) can be resolved by Helicobacter pylori eradication (HPE). Gastric MALT lymphoma is an indolent lymphoma derived from memory B cells in the marginal zone. In the present study, we aimed to explore the origin of large cells in HPE-responsive gastric DLBCLs (complete remission after HPE). We investigated gastric lymphoma biopsies from 31 patients with HPE-responsive DLBCLs [15 'pure' DLBCLs, 16 DLBCL(MALT)s]. We used the Hans algorithm (CD10, BCL-6, and MUM1) to define the origins of germinal center B cell (GCB) and non-GCB. To further ascertain the cellular origin, 11 'pure' DLBCLs were examined using an Agilent whole-human genome microarray. Eleven DLBCLs [eight with 'pure' DLBCL and three with DLBCL(MALT)] were also assessed using Lymph2Cx. Specific GCB markers, including BACH2, AID, and BCL2 rearrangement and enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) codon 641 mutations, were evaluated in 31 patients with HPE-responsive gastric DLBCLs. According to the Hans algorithm, 53% (8/15) of gastric 'pure' DLBCLs and 50% (8/16) of DLBCL(MALT)s were of the GCB phenotype. Gene expression assays revealed that five of six patients with 'Hans' GCB had GCB genetic signatures, whereas four of five patients with 'Hans' non-GCB had activated B-cell genetic signatures. The Lymph2Cx assay revealed the GCB subtype in seven of eight patients with 'Hans' GCB. The expression patterns of BACH2 (p = 0.005) and AID (p = 0.038) closely correlated with the 'Hans' GCB phenotype. BCL2 rearrangements and EZH2 codon 641 mutations were detected in 44% (7/16) and 13% (2/16) of patients with 'Hans' GCB, respectively. In another cohort of 29 HPE-unresponsive gastric DLBCLs [19 'pure' DLBCLs and 10 DLBCL(MALT)s], we found a close association between the 'Hans' GCB subtype and the GCB subtype as determined by the Agilent whole-human genome microarray and Lymph2Cx in lymphoma cells of these patients. In conclusion, more than half of HPE-responsive large cell lymphoma cases in the stomach were of GCB origin. © 2026 The Pathological Society of Great Britain and Ireland. - Source: PubMed
Publication date: 2026/08/05
Kuo Sung-HsinYeh Kun-HueiLin Chung-WuChen Li-TzongLiou Jyh-MingShun Chia-TungLee Hsiao-WeiWei Ming-FengWang Hsiu-PoWu Ming-ShiangCheng Ann-Lii - To screen the potential core targets of (2S)-2'-Methoxykurarinone, a dimethyldihydroflavonoid derived from Sophora flavescens, against sepsis. Furthermore, we explore the in vivo pharmacological efficacy and potential mechanism of action through bioinformatics analysis, clinical sample verification, and an LPS-induced zebrafish sepsis model, aiming to provide experimental evidence for the development of this compound as a candidate lead compound against sepsis. - Source: PubMed
Publication date: 2026/07/28
Deng YaxingWang ChenglinJin YantongHu YingchunXu Yan - This study investigated whether BACH2 affects bronchopulmonary dysplasia (BPD) through ferritinophagy and elucidated its molecular mechanisms. - Source: PubMed
Publication date: 2026/07/26
Zhao MenghuaWu YizhongWu BufeiXu JunWang DuaneHuang FurongZhang AiminHuang LiWu Xu - Genes that enhance T-cell function represent promising targets for improving engineered T-cell therapies for cancer. While extensive CRISPR knockout screens have identified key genes enhancing T-cell persistence, employing () insertional mutagenesis, which induces both gain-of-function (GOF) and loss-of-function (LOF) mutations via the generation of fusion transcripts with endogenous genes, may uncover additional critical factors that previous approaches have overlooked. - Source: PubMed
Publication date: 2026/07/15
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