BACH2 antibody - middle region (ARP33233_P050)
- Known as:
- BACH2 (anti-) - middle region (ARP33233_P050)
- Catalog number:
- arp33233_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- BACH2 antibody - middle region (ARP33233_P050)
Related genes to: BACH2 antibody - middle region (ARP33233_P050)
- Gene:
- BACH2 NIH gene
- Name:
- BTB domain and CNC homolog 2
- Previous symbol:
- -
- Synonyms:
- BTBD25
- Chromosome:
- 6q15
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-01-28
Related products to: BACH2 antibody - middle region (ARP33233_P050)
Related articles to: BACH2 antibody - middle region (ARP33233_P050)
- Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy with notable genetic, epigenetic, and clinical heterogeneity. This study utilized coding and non-coding sequencing (n=74), including whole-genome sequencing (WGS) on 24 paired tumour-normal samples, targeted sequencing (n=55) and DNA methylation in 126 cases to characterize the disease. From WGS, we identified recurrent, predominantly clonal, coding mutations in KLF2 (50%), KMT2D (25%) and NOTCH2 (25%), alongside rare mutations in FLNC (8%), novel mutations in FAM135B (17%) and non-coding mutational hotspots in BCL6, PAX5 and BACH2, linked to aberrant somatic hypermutation. At least one non-coding hotspot was detected in 69% of cases. Copy-number aberrations (CNAs) were present in 73% of cases, including del(7q) (27%), gain(3q) (17%) and trisomy 12 (13%). DNA methylation profiling revealed two epigenetic subgroups: SMZL-HR (high-risk, n=67) and SMZL-LR (low-risk, n=59). SMZL-HR was associated with adverse features such as female sex, IGHV1-2*04 usage, KLF2 mutations, del(7q), shorter telomeres, and elevated epiCMIT scores. Transcriptomic analysis highlighted enhanced cell proliferation in SMZL-HR, with enrichment of E2F and G2M checkpoint pathways and epigenetic regulation via EZH2. SMZL-HR patients had significantly shorter time to first treatment (TTFT) (HR: 1.9, p=.003) and reduced overall survival (HR: 2.5, p=.039): 85% of SMZL-HR patients required treatment and showed a higher frequency of transformation (p=.007) and mortality (p<.001). Multivariate analysis confirmed SMZL-HR as an independent predictor of shorter TTFT (HR: 2.4, p=.001). These findings demonstrate the role of DNA methylation and molecular profiling in SMZL risk stratification. - Source: PubMed
Publication date: 2026/05/27
Parker HelenMirandari AmattaStevens BenJaramillo-Oquendo CarolinaDuran-Ferrer MartíBuermann LaraAmarasinghe Harindra EranthiThomas JayaCarr LouiseSyeda ShamaSakthipakan MethushaParry MarinaRose-Zerilli Matthew JjDavis Zadie AMcIver-Brown Neil RXochelli AlikiEnnis SarahScarfò LydiaGhia PaoloKalpadakis ChristinaPangalis Gerassimos AlexanderRossi DavideGaidano GianlucaWagner Simon DAhearne Matthew JSeifert MarcPlass ChristophWeichenhan DieterKimby Eva KSutton Lesley-AnnRosenquist RichardAmini Rose-MarieLjungström ViktorPratt GuyForconi FrancescoStamatopoulos KostasSalido MartaFerrer AnaThieblemont CatherineHilton Laura KMorin Ryan DWalewska RenataMartin-Subero Jose IgnacioOscier David GrahamOakes Christopher CGibson JaneBryant DeanStrefford Jonathan C - Spinal cord injury (SCI) triggers a complex secondary injury cascade that critically limits neural repair. Although microRNAs have been implicated in post-SCI inflammation and neural regeneration, the key competing endogenous RNA (ceRNA) network regulating immune dysregulation remains unclear. - Source: PubMed
Publication date: 2026/05/07
Yao YuxuanGuo WenliangCai XingyunGui YuchangYao JingzhiLu YutingLiang YuxinWang WenshuTan ZhibiaoZhang JinxiangXu Jianwen - HIV integration into BACH2 is significantly enriched in people living with HIV (PLWH), but not in vitro . Specifically, HIV integration sites are enriched in the same orientation and upstream of BACH2 translation. HIV drives high levels of BACH2 expression through HIV-to- BACH2 splicing. BACH2, a transcription repressor that competes with AP-1 binding, is an effector-to-memory switch that restrains effector function, drives T cell stemness, and promotes long-lived memory. - Source: PubMed
Publication date: 2026/05/15
Ma Haocong KatherineBack HyeinWei YulongHo Ya-Chi - The BTB and CNC homology (BACH) proteins BACH1 and BACH2 are highly conserved transcriptional repressors that exert their effects by forming heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins. BACH1 is ubiquitously expressed and functions by competing with nuclear factor erythroid 2-like 2 (NRF2) for binding to MAF. By suppressing the transcription of heme oxygenase 1 (/), BACH1 inhibits the expression of genes involved in cellular oxidative stress responses. Expression of BACH2 is largely restricted to immune cells in both innate and adaptive compartments, where it plays a central role in hematopoietic development and immune cell differentiation. By engaging stretch or super-enhancers, BACH2 targets gene networks that include cytokines and cytokine receptors. Both BACH proteins have been implicated in numerous chronic diseases, including cancer and immune-mediated chronic inflammatory diseases. Aberrant activation is a key driver of BACH1-related pathogenesis, whereas BACH2 is typically linked to loss-of-function alterations. This article reviews the role of BACH proteins in diseases of the endocrine and exocrine pancreas, with a focus on type 1 and 2 diabetes mellitus, pancreatitis, and pancreatic cancer. Mechanistic aspects, pathophysiological correlations, and potential avenues for targeted therapies are discussed. - Source: PubMed
Publication date: 2026/04/22
Jaster Robert - The immune response to COVID-19 vaccines is diminished in older individuals. To understand the underlying immunobiology, we analyzed single-cell RNA-seq data from PBMCs of SARS-CoV-2 naive nursing home residents with varying humoral responses following BNT162b2 vaccination and validated via flow cytometry. Responders (R) (>4500 AU/mL anti-spike titers) showed enrichment for naive B cell () and naive CD4 T cell and early T follicular helper (Tfh)-related genes ( and ). Non-responders (NR) (<20 AU/mL) displayed elevated markers of T cell senescence (, , , and ), immune exhaustion (PD-1), and inflammation (TNF-α, IFN-γ). Flow cytometry revealed reduced CD4 T and B cell frequencies but higher CD8 T and NK cells in NR. Despite reduced B cell frequency, NR upregulated plasma B cell genes (), suggesting dysregulated B cell differentiation. Our findings point to impaired lymphocyte responses and increased immunosenescence in NR, emphasizing the need for enhanced vaccine strategies in aging populations. - Source: PubMed
Publication date: 2026/04/16
Ismail JeedaTamilselvan BanumathiRubsamen MichaelPetrosky JillianRichardson BrianZagore LeahOyebanji Oladayo AKeresztesy DebbiePayne MichaelWilk DennisCarias LenoreAung HtinSt Denis KerriSheehan MaeganWilson Brigid MBalazs Alejandro BGravenstein StefanKing Christopher LCanaday David HCameron Cheryl MCameron Mark J