Ovol2 Antibody - middle region (ARP33203_P050)
- Known as:
- Ovol2 Antibody - middle region (ARP33203_P050)
- Catalog number:
- arp33203_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Ovol2 Antibody - middle region (ARP33203_P050)
Related genes to: Ovol2 Antibody - middle region (ARP33203_P050)
- Gene:
- OVOL2 NIH gene
- Name:
- ovo like zinc finger 2
- Previous symbol:
- ZNF339, CHED1
- Synonyms:
- bA504H3.3, HOVO2, CHED
- Chromosome:
- 20p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-17
- Date modifiied:
- 2017-01-23
Related products to: Ovol2 Antibody - middle region (ARP33203_P050)
Related articles to: Ovol2 Antibody - middle region (ARP33203_P050)
- Colorectal cancer (CRC) progression involves metabolic reprogramming and immune evasion, but the link between glycolysis-driven epigenetics and immune checkpoints is unclear. OVOL2 is a tumor suppressor, yet its role in metabolic-immune crosstalk is unknown. In CRC cells and mouse models, we studied how OVOL2 loss enhances glycolysis and immune evasion. Multi-omics, CRISPR-Cas9, and pharmacological inhibition dissected the OVOL2-glycolysis-PD-L1 axis. Histone lactylation was assessed via immunoblotting and mutagenesis; OVOL2 PARylation by co-IP and PARP assays. Sulconazole's effects were tested in vitro/in vivo, with immune profiling by flow cytometry and multiplex IHC. OVOL2 deficiency increased glycolysis, lactate, and histone lactylation at the CD274 promoter, upregulating PD-L1 and promoting CD8+ T-cell exhaustion. Sulconazole inhibited glycolysis, reduced lactylation and PD-L1, and restored PARP1-mediated OVOL2 PARylation, inducing ASC-dependent PANoptosis. In mice, sulconazole suppressed tumor growth and metastasis. OVOL2 regulates metabolic-immune crosstalk in CRC. Sulconazole blocks glycolysis-driven PD-L1 expression and restores OVOL2 function, inducing PANoptosis and reversing immune evasion. Repurposing sulconazole offers a promising strategy for glycolytic, immunosuppressive CRC. - Source: PubMed
Zhang JiandongLi RuiZhuo ZuyinLi LiangheLi QingMu SongHe SiyaoChen WenLi LeiZhan Wei - - Source: PubMed
Publication date: 2026/05/08
- Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies, with nearly 80% of patients diagnosed at advanced stages due to the absence of early symptoms and the nonspecific nature of later clinical manifestations. This highlights the urgent need for robust molecular biomarkers that can refine patient stratification and guide personalized therapeutic approaches. A major determinant of OC aggressiveness is the epithelial-to-mesenchymal transition (EMT), a transcriptionally driven program that represses epithelial identity while promoting mesenchymal traits, thereby enhancing invasion, dissemination, recurrence, and resistance to therapy. EMT dysregulation is widespread in OC and fuels tumor heterogeneity, metastatic spread, and chemoresistance. To investigate the contribution of EMT-related genes in OC biology, we analyzed whole-genome sequencing and RNA-seq data from 419 patients in The Cancer Genome Atlas (TCGA) Pan-Cancer Atlas, assessing their genomic and transcriptomic alterations. We integrated these findings with transcriptomic and drug-sensitivity data from the CTRPv2 portal, performing Pearson correlation analyses to identify therapeutic vulnerabilities associated with EMT gene expression. Our analysis identifies recurrent genomic and transcriptomic alterations across several EMT-associated genes. Notably, we identified a four-EMT gene signature (EFNA1, OVOL2, GATA3, and DSG2) whose expression correlates with differential sensitivity to VEGFR and EGFR inhibitors in OC cell lines. Overall, these results suggest that EMT-driven molecular changes contribute to the onset and progression of OC and highlight a subset of EMT genes as promising predictive biomarkers for targeted therapy responses. - Source: PubMed
Publication date: 2026/02/25
Cassandri MatteoPontecorvi PaolaCece FabrizioCamero SimonaMele GiadaRomano EnricoCeccarelli SimonaRizzi RobertoMarampon FrancescoAngeloni AntonioMarchese CinziaMegiorni Francesca - Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits. Genome-wide association studies (GWAS) allow a better understanding of the genetic control of complex traits, especially those with low heritability (h). Therefore, this study aims to estimate the genetic parameters and to identify genomic regions and candidate genes associated with total number born (TNB), number born alive (NBA), and viable piglets at Day 5 (PV5) in a Large White female line. For this, 17,011 phenotypic records, 190,000 pedigree records, and 4366 animals genotyped with the Illumina 50 K and 80 K panels were used. Estimates of h, genetic (r) and phenotypic (r) correlations, and GWAS were performed with the BLUPF90 family programs. Positional candidate genes, their main biological processes, and networks were investigated using the Ensembl database and the BioMart, PANTHERdb, and STRING tools. The studied traits presented low h estimates, but with high and positive r and r. In the GWAS, 14 significant genomic windows were identified for TNB, 10 for NBA, and 15 for PV5. These regions include 157 genes for TNB, 101 for NBA, and 140 for PV5, mapped across 10 different chromosomes. Among the genes located in those regions, the ESR1, THRB, SLIT2, and ZBTB2 were common to the three traits and are involved in processes of hormonal regulation, embryogenesis, immunity, and homeostasis. Moreover, 12 of those genes were new positional candidates for TNB, NBA, or PV5. Among them, we highlight the FSTL4, PAPPA, and TCF7 genes associated with PV5, which are involved with hormonal regulation, growth factors, and immunity, respectively. The SLIT2, MTHFD1L, OVOL2, SHB, and EXOSC3 genes, involved with embryogenesis and neurogenesis, were associated with TNB and NBA. Furthermore, uncharacterized genes, such as ENSSSCG00000058091, related to mitochondrial homeostasis, were associated with TNB, while ENSSSCG00000040472, related to protein synthesis, was identified for PV5. These new findings reveal common and exclusive genetic mechanisms that may influence important litter traits in pigs, helping the development of breeding strategies to optimise reproductive efficiency. - Source: PubMed
Publication date: 2026/02/12
Oselame GuilhermePadilha Suelen FernandesCantão Maurício EgídioPeixoto Jane de OliveiraZampar AlineIbelli Adriana Mércia GuaratiniCarreño Luis Orlando DuitamaLopes Jader SilvaFreitas Pedro Henrique FerreiraFreitas Marcelo SilvaLedur Mônica Corrêa - Myeloma overexpressed gene (MYEOV) was initially identified as a gene amplified in several malignancies and was found to promote cell proliferation and metastasis. Our previous comparative RNA sequencing and epigenetic analyses revealed high MYEOV levels in differentiated corneal epithelial cells and showed that TET2 epigenetically regulated MYEOV expression. In the current study, we aimed to further characterize the expression and regulation of MYEOV in the human ocular surface. - Source: PubMed
Fukuda YoshikoZhang ChaoKsander Bruce RJo Vickie YLian Christine GMurphy George FFrank Markus HFrank Natasha YSasamoto Yuzuru