PURA antibody - middle region (ARP33202_P050)
- Known as:
- PURA (anti-) - middle region (ARP33202_P050)
- Catalog number:
- arp33202_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PURA antibody - middle region (ARP33202_P050)
Related genes to: PURA antibody - middle region (ARP33202_P050)
- Gene:
- PURA NIH gene
- Name:
- purine rich element binding protein A
- Previous symbol:
- -
- Synonyms:
- PURALPHA, PUR1, PUR-ALPHA
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2017-09-22
Related products to: PURA antibody - middle region (ARP33202_P050)
Related articles to: PURA antibody - middle region (ARP33202_P050)
- We explore the integration of climate action and Sustainable Development Goals (SDGs) in the first two submissions of nationally determined contributions (NDCs) using an AI-based, human-validated framework. Our goal is to provide ex-ante evidence relevant to assessing policy adequacy. We find disparities in topics of interest with high-income countries emphasizing systemic challenges (health, SDG3) and low-income nations prioritizing the water-energy-food nexus (SDGs 6-7-12) and natural resource management (SDG15). We discuss what these diverging development trajectories imply for the Paris Agreement and the 2030 Agenda for sustainable development in terms of global inequality, sustainable finance flows and multilateral governance. - Source: PubMed
Publication date: 2026/05/27
Larosa FrancescaRhomrassi Lamyae AHoyas SergioConejero J AlbertoGarcia-Martinez JavierMallor FerminNerini Francesco FusoVinuesa Ricardo - Developmental and epileptic encephalopathies (DEEs) with early burst-suppression EEG (EIDEE-BS) are among the most severe neonatal epileptic syndromes, typically presenting in the first months of life with refractory seizures and profound neurodevelopmental impairment. Although variants in the , , and genes are recognized as major causes, the full genetic spectrum remains uncertain. We aimed to delineate the electroclinical characteristics, genetic etiologies, and long-term outcomes in a large MRI-negative EIDEE-BS cohort. - Source: PubMed
Publication date: 2026/05/26
Riccardi FlorenceDesnous BéatriceBorloz EmilieLepine AnneLacoste CarolineMignon-Ravix CécileCacciagli PierreMissirian ChantalMolinari FlorenceMortreux JérémieAfenjar AlexandraAltuzarra CéciliaAuvin StéphaneBar ClaireBarth MagalieBiscaye StéphanieBourel-Ponchel EmilieCabasson SébastienCances ClaudeCastelnau PierreCaubel IsabelleCarneiro MarylineChabrol BrigitteChadie AlexandraChaussenot AnnabelleCheuret EmmanuelChouchane MondherCogné BenjaminColin EstelleDemurger FlorenceDesportes VincentDieux-Coeslier AnneDoummar DianeGoizet CyrilGoldenberg AliceGhoumid JamalGuerrot Anne-MarieHerenger YvanHeron DelphineHorvath GabriellaIlunga SergeIsidor BertrandJeanne MédéricJulia SophieKaminska AnnaLagrue EmmanuelleLambert LaetitiaLebre Anne-SophieLefranc JérémieLesca GaëtanLevrat VirginieMansour HichamMarey IsabelleMarret StéphaneMaurey HélèneMetreau JuliaMignot CyrilNaudion SophieNeveu JulienPatat OlivierPasquier LaurentPerrier Julie BoeswillwaldPetit FlorencePoulat Anne-LiseQuélin ChloéRichelme ChristianRollier PaulRondeau StéphaneRoubertie AgatheSchaefer EliseDe Saint-Martin AnneThauvin ChristelTorre StéphanieToutain AnnickVan Coster RudyVille Dorothée MVilleneuve NathalieVillard LaurentMilh Mathieu - is an opportunistic bacterium previously associated with dogs but has recently been found in human infections, raising zoonotic concerns. Genomic characterization of human isolates can provide preliminary information on antibiotic resistance, pathogenicity, and genomic features relevant to host range. Two isolates (hereafter referred to as EGH1 and EGH2) from human clinical samples in Egypt were sequenced using the Illumina NovaSeq X Plus platform. To assess genetic relatedness to human isolates worldwide, multilocus sequence typing (MLST), pangenome analysis, and antimicrobial resistance gene profiling were performed. The sequencing produced a total of 9,499,989 reads for EGH1 and 9,567,531 reads for EGH2. Sequences were assembled with Geneious Prime 2025 and annotated using NCBI Prokaryotic Genome Annotation Pipeline v6.10. Pangenome analysis identified 9574 genes, comprising 1681 core genes (17.56%), 180 soft-core genes (1.88%), 837 shell genes (8.74%), and 6876 cloud genes (71.82%). MLST was conducted on human genome assemblies using MLST v2.23.0. The analysis revealed both isolates as novel sequence types: EGH1 was assigned ST-3037 with a new allele (-107), and EGH2 was assigned ST-2874. Clonal relationships among isolates were evaluated using the eBURST algorithm. This study presents the first next-generation genome sequencing and comparative genomic analysis of isolates from humans in Egypt. Future studies integrating genomic, epidemiological, and phenotypic data are required. - Source: PubMed
Publication date: 2026/04/27
Elsakhawy Ola KElaadli HaithamBadr YassienRaouf MayKania Stephen AAltaib HendAbouelkhair Mohamed A - Anthropogenic underwater noise poses a significant threat to marine ecosystems, disrupting key biological functions. Common mitigation strategies include enclosing noise sources within acoustic barriers. Current designs include locally resonant absorbers, which offer narrow-band performance, and reflective systems with limited effectiveness at low frequencies. In this work, we propose an approach to design thin anisotropic metamaterial-based acoustic barriers for broadband underwater noise attenuation at deep sub-wavelength scales using topology optimization to maximize the coupling between normal stresses and shear strains. Unlike conventional methods, the proposed optimization is formulated in the static regime, relying solely on the homogenized elastic properties of the structured material and not on the characteristics of the surrounding fluid. The resulting metabarriers achieve a high sound transmission loss (STL, 100 dB peak) above 2 kHz, while maintaining a thickness-to-wavelength ratio as low as 1/70 below 1 kHz and STL of approximately 20-30 dB. The influence of hydrostatic pressure on performance is also evaluated, and structural modifications for practical deployment are proposed. The results demonstrate the potential of anisotropy-driven metamaterials as compact and efficient solutions for the control of underwater noise, offering a promising avenue for future acoustic insulation technologies. - Source: PubMed
Publication date: 2026/05/18
Dal Poggetto Vinícius FMiniaci Marco - Conformational traits define a horse's shape and morphology, heavily influencing its functionality, sport performance, health, and appearance, making conformation a critical selection criterion in horse breeding. However, the genomic basis of conformational defects, specifically those affecting the hock, remains largely unexplored. This research aimed to identify the genomic regions associated with hock defects using a large cohort of Pura Raza Española (PRE) horses. A total of 58,930 horses were evaluated for hock angle, with 4,122 genotyped on high- or medium-density arrays. For this purpose, weighed single-step genomic REML analysis methodology was used with the hock evaluation assessed as a continuous variable (lateral view hock defect, LVHD, and rear-view hock defect, RVHD) and divided into two different opposite defects: closed and open and convergent and divergent, respectively (multinomial approach). Some deviation from the optimum hock angle was observed in 49,386 horses, of which 10.1% were evaluated as having a severe or very severe defect. The most prevalent hock defect in the PRE population evaluated was open hock (6.67% considered severe or very severe), while the least prevalent was closed hock (0.2%). The estimated heritability for the continuously evaluated traits was 0.18 for LVHD and 0.25 for RVHD, while the estimated heritability of the traits evaluated with a multinomial approach ranged from 0.25 to 0.42 for open and divergent defects, respectively. A genome-wide association study revealed eight genomic regions associated with hock defects. In these, 17 genes related to musculoskeletal diseases, bone malformations, joint disorders, cartilage defects, or bone fragility were identified. These findings could support the development of selective breeding strategies aimed at reducing conformational defects in the hock of the PRE and related breeds. Furthermore, they provide insight into the genetic and molecular mechanisms involved in the occurrence of conformation defects. However, further studies are needed to shed further light on these conformational defects in the equine species. - Source: PubMed
Laseca NoraMolina AntonioZiadi ChirazPerdomo-Gonzalez Davinia IValera Mercedes