PURA antibody - N-terminal region (ARP33201_P050)
- Known as:
- PURA (anti-) - N-terminal region (ARP33201_P050)
- Catalog number:
- arp33201_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PURA antibody - N-terminal region (ARP33201_P050)
Related genes to: PURA antibody - N-terminal region (ARP33201_P050)
- Gene:
- PURA NIH gene
- Name:
- purine rich element binding protein A
- Previous symbol:
- -
- Synonyms:
- PURALPHA, PUR1, PUR-ALPHA
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2017-09-22
Related products to: PURA antibody - N-terminal region (ARP33201_P050)
Related articles to: PURA antibody - N-terminal region (ARP33201_P050)
- Pediatric inflammatory multisystem syndrome (PIMS), also referred to as multisystem inflammatory syndrome in children (MIS-C), is a rare but serious post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection characterized by systemic hyperinflammation and multiorgan involvement. New-onset neurological and psychiatric symptoms have emerged as critical clinical features, occurring in approximately 12-27% of pediatric patients aged 2-15 years (median age, 10 years) and often indicating a more severe disease course. This narrative review aims to provide a comprehensive overview of the current literature regarding the neurological and psychiatric manifestations of PIMS/MIS-C, focusing on epidemiology, pathophysiology, clinical presentation, neuroimaging findings, biomarkers, treatment strategies, and outcomes. A narrative literature review was conducted to synthesize current evidence on the neurological and psychiatric spectrum of PIMS/MIS-C. Evaluated parameters included clinical presentations ranging from common symptoms (such as headache, encephalopathy, altered mental status, and seizures) to rare complications (such as ischemic stroke, acute disseminated encephalomyelitis, Guillain-Barré syndrome, and cerebral edema), alongside associated psychiatric disturbances, diagnostic findings, and therapeutic approaches. Neurological and psychiatric manifestations significantly impact the clinical trajectory of PIMS/MIS-C. Acute symptoms include headache, encephalopathy, seizures, and psychiatric disturbances like behavioral changes, hallucinations, delirium, anxiety, and sleep disorders. Neuroimaging in many cases reveals reversible lesions of the splenium of the corpus callosum, while electroencephalography typically demonstrates diffuse slowing consistent with encephalopathy. Early recognition and prompt administration of immunomodulatory therapy-primarily intravenous immunoglobulin and corticosteroids-correlate with favorable neurological recovery in the majority of patients. However, current evidence remains largely observational and heterogeneous, precluding definitive causal conclusions regarding this treatment-outcome relationship. Affected children more frequently require intensive care unit admission and remain at risk for persistent cognitive, behavioral, and psychiatric sequelae. Neurological and psychiatric complications in PIMS/MIS-C are clinically significant indicators of disease severity that require vigilant monitoring and early immunomodulatory intervention. Continued multidisciplinary follow-up and prospective studies are essential to elucidate the long-term neurodevelopmental and psychiatric consequences and to optimize therapeutic strategies for these patients. - Source: PubMed
Publication date: 2026/08/31
Śliwiński WiktorPura WeronikaMatecka DominikaKosowski MateuszChołuj DanielMarciniak JakubMazur JakubZarówna KarolinaDamodaran LaavanyaSzejko Natalia - The critical period from 3 weeks prepartum to 3 weeks postpartum is considered the transition period and is characterized by major endocrinological and metabolic changes that can lead to production and infectious diseases. In addition, decreased dry matter intake and altered nutritional requirements are evident during this period. The objective of our study was to analyze the effects of transition feed fed to buffaloes on major hematobiochemical parameters, oxidative stress, cytokine levels, and mRNA expression of molecular markers associated with production diseases. - Source: PubMed
Publication date: 2026/09/08
Kour SavleenSharma NeeleshLee Sung-Jin - PURA heterozygous microdeletions and pathogenic variants have been previously associated with neurodevelopmental disorders (NDDs), grouped into PURA-NDDs, characterized by severe neonatal hypotonia, feeding difficulties, developmental delay, intellectual disability, epilepsy, and distinctive facial features. Here we report four individuals carrying overlapping 5q31 duplications encompassing PURA, in addition to five cases from the DECIPHER database and one previously described in the literature. All patients share common features including developmental delay and mild to moderate intellectual disability. The minimal region of overlap spans 215 kb and contains only the PURA gene, suggesting PURA as the candidate gene underlying the observed phenotype. Using transcriptomic and biochemical analyses on cultured lymphocytes from one patient, we found that 5q31 duplication causes a significant upregulation of PURA mRNA and PURA protein, respectively. RNA Sequencing also revealed dysregulated expression of various genes involved in human pathology, especially in neurodevelopmental disorders characterized by intellectual disability. Using primary hippocampal neuronal cultures from mouse embryos, we demonstrated that PURA overexpression impairs neuronal morphology in vitro, inducing a reduction in dendritic arborization and in dendritic spine density. Our findings support that 5q31 duplications encompassing PURA represent a novel genomic disorder presenting with a milder phenotype than the reciprocal deletion syndrome and implicate PURA dosage dysregulation as a key contributor to the associated clinical features. - Source: PubMed
Publication date: 2026/09/22
Challeat LaurineRemize SolèneAlouane TarekLaurenceau DavidBoisseau ChloéHubert CatherineCelton NoémieLe Du NathalieVonwill SandrineGevrin CamilleKerbellec LaraPebrel-Richard CélineEgloff MatthieuNavarro CarolinePerthus IsabelleNiclass TanguyCaumes RoselineFauqueux JadeJeanne MédéricSmol ThomasLaumonnier FrédéricVuillaume Marie-Laure - Single-port transvesical robot-assisted radical prostatectomy (SP-TVRP), which enables early continence outcomes, has recently emerged. This study aimed to describe objective postoperative urodynamic findings at 3 months after SP-TVRP and to determine whether these findings are compatible with early continence recovery in a preliminary prospective physiologic case series. - Source: PubMed
Publication date: 2026/07/21
Ko Kwang JinChung Jae Hoon - Intermittency, manifested through anomalous scaling, remains one of the central unresolved problems in turbulence theory, with few analytical approaches extending beyond idealized linear transport models. We introduce a perturbative framework for anomalous scaling in turbulent transport based on multiplier statistics, rather than zero-mode calculations. We demonstrate the approach using a shell model combining deterministic and Kraichnan-like stochastic components. We reduce the problem to the analysis of a stationary Fokker-Planck equation for Kolmogorov multipliers, defined as ratios of successive scalar amplitudes. Its solution yields the invariant measure through a perturbative expansion around a Gaussian distribution. Using the resulting multiplier statistics, we compute explicit anomalous scaling exponents for structure functions of arbitrary order, including odd, even, and noninteger moments. Although demonstrated here for a shell model, the framework suggests a systematic perturbative route toward analytical theories of intermittency in turbulence. - Source: PubMed
Mailybaev Alexei AThalabard Simon