TRERF1 antibody - C-terminal region (ARP33158_P050)
- Known as:
- TRERF1 (anti-) - C-terminal region (ARP33158_P050)
- Catalog number:
- arp33158_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- TRERF1 antibody - C-terminal region (ARP33158_P050)
Related genes to: TRERF1 antibody - C-terminal region (ARP33158_P050)
- Gene:
- TRERF1 NIH gene
- Name:
- transcriptional regulating factor 1
- Previous symbol:
- BCAR2
- Synonyms:
- TReP-132, HSA277276, RAPA, dJ139D8.5
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2016-10-05
Related products to: TRERF1 antibody - C-terminal region (ARP33158_P050)
Related articles to: TRERF1 antibody - C-terminal region (ARP33158_P050)
- Rathi cattle, an indigenous Bos indicus breed of north-western India, represent a valuable genetic resource due to their adaptation to arid environments, heat tolerance and dairy potential. However, genomic information on this breed remains limited. This study provides the first double-digest restriction-site associated DNA sequencing (ddRAD) based genome-wide assessment of Rathi cattle using a large sample size. A total of 96 animals were genotyped, generating 78,193 high-quality SNPs with 96.52% alignment to the Bos taurus (ARS-UCD2.0) reference genome, guaranteeing dependable variant identification. The population exhibited moderate genetic diversity with nucleotide diversity (π = 0.33 ± 0.09) and heterozygosity (Ho = 0.291 ± 0.084; He = 0.329 ± 0.104). Runs of homozygosity (ROH) made up 5.43% of the genome, and most of them were short segments (< 2 Mb), which shows that there hasn't been much inbreeding lately (F = 0.0512). Effective population size (Ne) declined from 1454 (150 generations ago) to 94 at present, highlighting the impact of demographic bottlenecks and genetic drift. The declining Ne suggests a risk of future genetic erosion, highlighting the need for effective conservation and breeding strategies. Population structure analyses (PCA, ADMIXTURE and STRUCTURE) revealed clear genetic distinctness of Rathi from other indigenous dairy breeds, despite its composite origin. Selection signature analyses (Tajima's D, CLR, ROH islands and iHS) identified candidate regions harboring genes associated with immunity (IL2RB, USP18), reproduction (INHBA, MEI4, HBA), lactation (LRRC8D, TRERF1, CCND3) and stress adaptation (CARHSP1, ITGAV). These findings are highlighting the valuable insights about diversity, demographic history and adaptive potential of rathi and offering genomic resources for conservation, sustainable utilization and genetic improvement programs. - Source: PubMed
Publication date: 2026/07/08
Bharia NishuBose AnalNayak Sonali SonejitaRajawat DivyaKumar VijayDutt TriveniPanigrahi Manjit - Obesity is a recognized risk factor for numerous cancers. Although several biological mechanisms have been proposed to explain obesity-associated carcinogenesis, the extent to which excess adiposity influences tumor genomic profiles remains incompletely understood. In particular, whether obesity-related selective pressures shape cancer-specific mutational landscapes is still underexplored. - Source: PubMed
Publication date: 2026/03/23
Porcelli GaetanaBrancaccio Rosario NicolaDi Bella SebastianoD'Accardo CaterinaOrilio FrancescoPantina Vincenzo DavideModica ChiaraVerona FrancescoBianca PaolaMorgante CesareDi Franco SimoneGaggianesi MiriamVeschi VeronicaStassi GiorgioTurdo AliceTodaro Matilde - Large porcine F crosses are a valuable resource for discovering QTL and genetic variants for relevant traits. Past studies have been largely limited to SNPs and short insertions and deletions. Structural variants (SVs) are becoming a major area of interest in this respect. Here we present results from a genome-wide association study with SVs imputed from medium-density SNP array to the whole genome sequence level that were used to investigate the genetic relationship between important production traits and metabolic enzyme activity in an F cross based on the breeds Meishan, Piétrain, and European wild boar. Genetic and phenotypic correlations between the two trait classes were high. We were able to pinpoint common genetic loci to a QTL on SSC7, encompassing numerous large intron deletions in the PRIM2 gene as well as in HMGCLL1, BMP5, TRERF1, COL21A1, LRRC1, and UBR2. The most pronounced genetic associations were observed for the content of NADP-malate dehydrogenase in the tissue. Hence, we propose that the content and activity of malate dehydrogenase is directly connected to important pig production traits, and we present a comprehensive list of large intronic deletions as promising candidates for causality. The variants were validated in independent pig populations, where the majority of the discovered SVs were present, indicating that they are not only relevant to the breeds investigated here. - Source: PubMed
Falker-Gieske ClemensBlaj IuliaKrizanac Ana-MarijaKilic IsabelReich PaulaBennewitz JörnTetens Jens - BACKGROUND: This study leveraged whole-genome resequencing to investigate the genetic architecture, population structure, and kinship dynamics of the Hetian sheep population. By integrating genomic data with reproductive trait analysis, we aimed to identify key candidate genes associated with litter size. The findings provide new insights into the genetic mechanisms underlying litter size and establish a molecular foundation for the application of marker-assisted selection and genetic improvement in sheep breeding. RESULTS: WGRS was performed on 198 Hetian sheep. After stringent quality control, 5,483,923 high-quality SNPs were retained for downstream analysis and functionally annotated using ANNOVAR. Population genetic structure was assessed based on stratification patterns and kinship coefficients. The analysis revealed that the Hetian sheep population harbors substantial genetic diversity and exhibits a generally low level of inbreeding. Among the individuals analyzed, 157 were grouped into 16 families based on third-degree kinship (kinship coefficients between 0.12 and 0.25), while 41 individuals showed no detectable third-degree relationships, suggesting high genetic independence within the population. A genome-wide association study (GWAS) using a general linear model (GLM) identified 11 candidate genes potentially associated with litter size, including LOC101120681, LOC106990143, LOC101114058, GALNTL6, CNTNAP5, SAP130, EFNA5, ANTXR1, SPEF2, ZP2, and TRERF1. Among these, 23 SNPs located within five core candidate genes (LOC101120681, LOC106990143, LOC101114058, GALNTL6, and CNTNAP5) were selected for validation using the Sequenom MassARRAY® genotyping platform. Of the 23 SNPs tested, 22 were confirmed as true variants. However, the majority (17/22) showed no statistically significant association with litter size (P >0.05), highlighting the need for further validation in larger populations. CONCLUSIONS: Although the Hotan sheep population exhibits high genetic diversity and low levels of inbreeding, most SNPs are not significantly associated with litter size, indicating that there are currently some limitations to this study. These results should be considered preliminary and require further validation in larger and more diverse populations. - Source: PubMed
Publication date: 2025/11/06
Liu BoLiu ShihaoLi PengfeiTulafu HanikziMa YanpingHuang JunchengWu Weiwei - Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B cells (NBC), IgD unswitched (unsw)MBCs and IgG or IgA class-switched (sw)MBCs from humans of different age, sex and race. Conserved antibody variable gene expression indicates that MBCs emerge through unbiased selection from NBCs. Integrative analyses of mRNAs, miRNAs, lncRNAs, chromatin accessibility and cis-regulatory elements uncover a core mRNA-ncRNA transcriptional signature shared by IgG and IgA swMBCs and distinct from NBCs, while unswMBCs display a transitional transcriptome. Some swMBC transcriptional signature loci are accessible but not expressed in NBCs. Profiling miRNAs reveals downregulated MIR181, and concomitantly upregulated MIR181 target genes such as RASSF6, TOX, TRERF1, TRPV3 and RORα, in swMBCs. Finally, lncRNAs differentially expressed in swMBCs cluster proximal to the IgH chain locus on chromosome 14. Our findings thus provide new insights into MBC transcriptional programs and epigenetic regulation, opening new investigative avenues on these critical cell elements in human health and disease. - Source: PubMed
Publication date: 2020/10/28
Moroney Justin BVasudev AnushaPertsemlidis AlexanderZan HongCasali Paolo