AHCYL1 antibody - N-terminal region (ARP33131_P050)
- Known as:
- AHCYL1 (anti-) - N-terminal region (ARP33131_P050)
- Catalog number:
- arp33131_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- AHCYL1 antibody - N-terminal region (ARP33131_P050)
Related genes to: AHCYL1 antibody - N-terminal region (ARP33131_P050)
- Gene:
- AHCYL1 NIH gene
- Name:
- adenosylhomocysteinase like 1
- Previous symbol:
- -
- Synonyms:
- XPVKONA, IRBIT, PPP1R78
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-23
- Date modifiied:
- 2018-05-03
Related products to: AHCYL1 antibody - N-terminal region (ARP33131_P050)
Related articles to: AHCYL1 antibody - N-terminal region (ARP33131_P050)
- This study investigated the molecular regulation of uterine calcium ion (Ca²⁺) transport during the oviposition cycle in Guizhou Sansui ducks. Uterine tissues were collected at 0, 2, 5, and 16 h after oviposition to determine Ca²⁺ concentrations and quantify the mRNA levels of ten Ca²⁺ transport-related genes, including transient receptor potential vanilloid 6 (TRPV6), inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), inositol 1,4,5-trisphosphate receptor type 2 (IP3R2), inositol 1,4,5-trisphosphate receptor type 3 (IP3R3), solute carrier family 4 member 4 (SLC4A4), solute carrier family 4 member 9 (SLC4A9), potassium inwardly-rectifying channel subfamily J member 15 (KCNJ15), sodium channel epithelial subunit gamma (SCNN1G), adenosyl homocysteinase-like 1 (AHCYL1), and protein kinase C alpha (PRKCA). In addition, the expression profiles of these ten genes were assessed across 12 tissues (heart, liver, spleen, lung, kidney, large intestine, small intestine, duodenum, pancreas, proventriculus, gizzard, and pectoral muscle) at the four oviposition time points. The results showed that the Ca²⁺ concentration in the uterine tissue was relatively low at 0 h, increased at 2 h and 5 h (P < 0.01), and reached its peak at 16 h (P < 0.01). The expression of the ten genes showed an overall upward trend, with TRPV6 slightly decreasing initially and then continuously increasing. Correlation analysis revealed that at 0 h, uterine Ca²⁺ concentration was negatively correlated with IP3R2 and KCNJ15 (P < 0.05), while IP3R2 was positively correlated with KCNJ15 (P < 0.05). At 2 h, TRPV6 expression was negatively correlated with both Ca²⁺ concentration and KCNJ15 (P < 0.05). At 16 h, Ca²⁺ concentration was negatively correlated with SCNN1G but positively correlated with SLC4A9 (P < 0.05). All ten genes were expressed across 12 tissues, showing distinct temporal and spatial patterns. These results suggest that TRPV6, IP3Rs (IP3R1, IP3R2, and IP3R3), SLC4A4/9, KCNJ15, SCNN1G, AHCYL1, and PRKCA may cooperatively regulate uterine Ca²⁺ absorption, intracellular release, and local homeostasis, while their tissue-specific expression reflects systemic regulation of calcium metabolism. - Source: PubMed
Publication date: 2026/01/09
Zhao YongLiao ChaomeiFu HongmeiDing YijieGuo XingchenZhang Yiyu - Milk protein content represents a key economic trait in dairy production, yet the genetic architecture underlying this trait remains unexplored in Romanian dual-purpose cattle breeds. This study conducted a genome-wide association analysis for milk protein content in 313 Romanian Simmental (n = 271) and Romanian Brown (n = 42) cows belonging to the Research and Development Station for Bovine Arad, Romania. Following quality control, 33,531 SNPs were tested for association with protein percentage adjusted for other effects (breed, days in milk, season, year, parity) using linear regression with the first five principal components as covariates to control population stratification. Although no SNP reached genome-wide significance ( < 5 × 10), one SNP achieved significance ( < 2.98 × 10) and seven additional SNPs exceeded the nominal threshold ( < 1 × 10) across six chromosomes. The strongest association ( = 9.56 × 10) mapped to chromosome 25 near . Biologically relevant candidate genes included on chromosome 13, previously associated with milk traits in Chinese Holstein, and on chromosome 3, involved in calcium homeostasis. These findings provide initial insights into genomic regions influencing milk protein content in Romanian dual-purpose cattle, though validation in larger cohorts needs to be carried out. - Source: PubMed
Publication date: 2025/10/26
Bratu Daniel GeorgeBlaga ȘerbanZanfira Bianca CorneliaMircu CălinSpătaru Ioana IrinaTorda IuliuMizeranschi Alexandru EugeniuIlie Daniela ElenaCziszter Ludovic TomaVizitiu Dorin AlexandruBoldura Oana MariaHuțu Ioan - Atherosclerosis (AS) is prevalent among the elderly population and poses a significant global health burden. However, the precise underlying mechanisms linking aging and mitochondrial dysfunction in AS remain unclear. - Source: PubMed
Publication date: 2025/07/21
Wang LinHan YuxiuQiao YuYan TaoQi ZhiZhang WeiXin LingYu MingjingChen Zhili - Severe acute malnutrition (SAM) contributes to the death of millions of children under age five annually. SAM is clinically classified as non-edematous SAM (NESAM) or the more severe edematous SAM (ESAM), which is more common in east-central Africa and the Caribbean. The reason some children develop ESAM while others develop NESAM remains unclear; however, recent studies have identified aberrant one-carbon metabolism (OCM) in ESAM relative to NESAM. Here, we assess genetic variants at 103 loci known to influence OCM, and determine their association with ESAM in 711 samples from Jamaica and Malawi. Seven OCM loci showed evidence of association across both populations, including five associated with homocysteine and folate metabolism (, , , , and ). Three SNPs in , , and , genotyped using cell-free DNA from serum metabolomic samples, supported causal effects on ESAM risk through homocysteine-related metabolites. Cumulatively, OCM-related variants showed more association with ESAM than expected by chance (z = 3.06), with differing effect magnitudes in the two populations. By leveraging chromosomelevel patterns of intracontinental African admixture, we demonstrate that OCM variant associations with ESAM occur on a shared east-African ancestral genetic background. Finally, using whole genome sequence data from eight African populations, we demonstrate that several OCM loci have outlier signatures of selection in multiple populations, including the ESAM-associated locus. These findings strengthen support for aberrant OCM in ESAM pathogenesis, with implications for current interventions, and highlight the potential of cell-free DNA, intra-continental admixture, and population genetics in mapping disease risk. - Source: PubMed
Publication date: 2025/06/29
Hanchard NeilLie NatashaHan YixingLi QingJajoo AartiRedmond JaredHaldipur AparnaZewdu SolomeBanfield EmilynSwaminathan ShankerHowell SharonBrown OrgenSadat RoaHall NancySchulze KatharinaMay ThaddaeusReid MarvinManary MarkTrehan IndiMbiyavanga MamanaAkurugu WisdomMcKenzie ColinSengupta DhritiAtkinson ElizabethChoudhury AnanyoMarshall KwesiTaylor-Bryan Carolyn - A large-scale longitudinal epidemiological study by the Hisayama study revealed that the concentration of one-carbon metabolism-related amino acids in the serum changes with age and that there is a link between these fluctuations and the risk of developing dementia (Hata et al. in Am J Epidemiol 188:1637-1645, 2019; Mihara et al. in Sci Rep 12:12427, 2022). Therefore, the aim of this study was to focus on age-related changes in one-carbon metabolism-related amino acids and elucidate the regulatory basis of these changes. Treatment with etoposide, an anti-cancer drug, induced cellular senescence in SH-SY5Y cells, as indicated by increased senescence-associated β galactosidase activity and upregulated expression of senescence markers and . Liquid chromatography-mass spectrometry analysis revealed that the intracellular amino acid concentrations, particularly those involved in the one-carbon metabolism, were elevated in senescent cells, including those of methionine, S-adenosylmethionine, S-adenosylhomocysteine (SAH), homocysteine (Hcys), and related metabolites. The results of the expression analysis focused on the enzyme genes involved in Hcys metabolism and revealed that the induction of cellular senescence upregulated (), which convert SAH to Hcys. Additionally, the genes involved in Hcys metabolism via the sulphuration pathway ( and ) were significantly upregulated. Because Hcys has been implicated in aging, further investigations focused on . Gene knockdown of in etoposide-treated cells reduced and expression, indicating that is essential for cellular senescence induction. These findings suggest that Hcys accumulation and its metabolic enzymes play a crucial role in cellular senescence. - Source: PubMed
Publication date: 2025/06/30
Jiahao WangKameyama JunUdono MiyakoKatakura Yoshinori