FOXO1 antibody - middle region (ARP32976_P050)
- Known as:
- FOXO1 (anti-) - middle region (ARP32976_P050)
- Catalog number:
- arp32976_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FOXO1 antibody - middle region (ARP32976_P050)
Related genes to: FOXO1 antibody - middle region (ARP32976_P050)
- Gene:
- FOXO1 NIH gene
- Name:
- forkhead box O1
- Previous symbol:
- FKHR, FOXO1A
- Synonyms:
- FKH1
- Chromosome:
- 13q14.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-07
- Date modifiied:
- 2016-10-05
- Gene:
- LINC00598 NIH gene
- Name:
- long intergenic non-protein coding RNA 598
- Previous symbol:
- -
- Synonyms:
- TTL, lncFOXO1
- Chromosome:
- 13q14.11
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2012-05-01
- Date modifiied:
- 2018-07-26
Related products to: FOXO1 antibody - middle region (ARP32976_P050)
Related articles to: FOXO1 antibody - middle region (ARP32976_P050)
- Uterine fibroids (UF) is the most common benign tumour of the female reproductive system. We investigated the joint contribution of genome-wide association studies (GWAS)-significant loci and environment-associated risk factors to the UF risk, along with epistatic interactions between single nucleotide polymorphisms (SNPs). - Source: PubMed
Ponomareva LiubovKobzeva KseniaBushueva Olga - Data derived from genomic and transcriptomic analyses have revealed that long noncoding RNAs (lncRNAs) have important roles in the transcriptional regulation of various genes. Recent studies have identified the mechanism underlying this function. To date, a variety of noncoding transcripts have been reported to function in conjunction with epigenetic regulator proteins. In this study, we investigated the function of linc00598, which is transcribed by a genomic sequence on chromosome 13, downstream of FoxO1 and upstream of COG6. Microarray analysis showed that linc00598 regulates the transcription of specific target genes, including those for cell cycle regulators. We discovered that linc00598 regulates CCND2 transcription through modulation of the transcriptional regulatory effect of FoxO1 on the CCND2 promoter. Moreover, we observed that knockdown of linc00598 induced G0/G1 cell cycle arrest and inhibited proliferation. These data indicate that linc00598 plays an important role in cell cycle regulation and proliferation through its ability to regulate the transcription of CCND2. - Source: PubMed
Publication date: 2016/08/30
Jeong Oh-SeokChae Yun-CheolJung HyeonsooPark Soon CheolCho Sung-JinKook HyunSeo SangBeom