ZFAT1 antibody - middle region (ARP32966_P050)
- Known as:
- ZFAT1 (anti-) - middle region (ARP32966_P050)
- Catalog number:
- arp32966_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZFAT1 antibody - middle region (ARP32966_P050)
Related genes to: ZFAT1 antibody - middle region (ARP32966_P050)
- Gene:
- ZFAT NIH gene
- Name:
- zinc finger and AT-hook domain containing
- Previous symbol:
- ZNF406, ZFAT1
- Synonyms:
- KIAA1485
- Chromosome:
- 8q24.22
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-29
- Date modifiied:
- 2016-10-05
Related products to: ZFAT1 antibody - middle region (ARP32966_P050)
Related articles to: ZFAT1 antibody - middle region (ARP32966_P050)
- Mature body size and weight of sheep are important traits that significantly influence mutton yield and economic benefits of sheep farming. The exploration for key genes underlying these traits will facilitate the advancement of molecular breeding in meat sheep. In this study, key candidate genes for five body size traits and the body weight were identified in mature Huameng meat sheep through GWAS and ROH analysis. After quality control, 451 individuals and 16 751 761 variants were analyzed using EMMAX software in a linear mixed model (LMM). A total of 3 genome-wide and 35 chromosome-wide significant SNPs were identified, respectively. Several key candidate genes have been uncovered, including ZFAT, ACSL3, and GRID2 for cannon bone circumference; UNC5C and BMPR1B for body weight and chest girth; PCDH15 and NUP93 for hip width; and PTPRD for body height. ROH analysis revealed a high-frequency ROH hotspot region on chrX. In addition, ROH analysis suggested that inbreeding may lead to a significant depression in body height of sheep. This study provides important clues for revealing the molecular mechanisms underlying sheep body morphological traits and identifies key candidate genes for molecular breeding in meat sheep. - Source: PubMed
Wang Y FGong Y MChen H SWang Y FChen Q JChen KSong Y ZMeng ZZhang G QLi HChu M XDi R - The comparative effectiveness of different hyperbaric oxygen (HBO) therapy doses in the acute treatment of central retinal artery occlusion (CRAO) has not been evaluated. - Source: PubMed
Publication date: 2026/02/10
Gur IvanGur InbarGitzman MichaelAtal LeahMatsliah YinnonZaher ElieDuvdevan-Strier NitsanNov Yuval - Cell cycle checkpoints are essential for proper cell division and genomic integrity. Here, we identify the nuclear zinc finger protein ZFAT as a novel and essential regulator of the G1/S transition. Using siRNA-mediated knockdown in HT1080 human fibrosarcoma cells, we investigated the consequences of ZFAT depletion on cell cycle progression. Propidium iodide-based DNA content analysis revealed that ZFAT depletion caused G1 accumulation and a reduced proportion of S-phase cells, detectable as early as 24 h post-transfection. Consistently, ZFAT silencing reduced DNA synthesis, as shown by EdU incorporation assays, and decreased the proportion of S-phase cells, as confirmed by cyclin A2 immunofluorescence. Furthermore, using a double-thymidine block to synchronize the cell cycle, we found that ZFAT-depleted cells largely failed to progress from G1 into S phase. Together, these complementary observations directly demonstrate that ZFAT depletion blocks the G1/S transition. Importantly, this phenotype was consistently observed in additional cancer cell lines, HCT116 and HeLa cells, as well as in non-transformed RPE1 cells, indicating that ZFAT-dependent regulation of G1/S transition is broadly conserved across diverse human cell types. Together, these findings establish ZFAT as a conserved and essential regulator of G1/S transition in human cells. - Source: PubMed
Publication date: 2026/01/03
Maeoka HisanoriMaruta GenIshikura ShuheiTsunoda ToshiyukiTakagi SatoshiAkiyoshi KozaburoShirasawa Senji - Israel relies heavily on foreign-trained physicians, with approximately 58% of all its practicing physicians having received their medical education abroad. The Israeli Ministry of Health (MOH) has estimated a 30% non-return rate (i.e., the proportion of Israeli medical graduates who remain abroad after completing their studies, rather than returning to practice in Israel) among Israeli medical graduates studying abroad. However, this estimate is based on limited data. This study explores the self-reported class non-return rate among Israeli medical graduates from foreign medical schools and examines potential factors influencing their decision to remain abroad. - Source: PubMed
Publication date: 2025/10/29
Swechinsky TomerBerner-Shalem Rachel - Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age-related diseases and might contribute to the development of both sarcopenia and frailty. In this study, we investigated the contribution of multi-omics data to sarcopenia, frailty, lean mass index (LMI) and handgrip strength in an elderly Lithuanian population. A total of 204 participants (age 82.2 ± 7.6 years) were included, comprising 122 individuals diagnosed with sarcopenia and/or frailty and 82 healthy, community-dwelling older adults. The results showed that LMI was associated with various health and lifestyle factors. Two genetic variants, CLIC5 rs75652203 and GHITM rs17102732, were found to be significantly associated with handgrip strength at the genome-wide level. Additionally, 12 polymorphisms previously linked to sarcopenia were replicated in relationship to LMI: BOK rs76993203, VAMP5 rs1374370, TMEM18 rs12714414, SFMBT1 rs36033494, BANK1 rs13136118, TET2 rs2647239, FOXO3 rs9384679, L3MBTL3 rs13209574, ZFAT rs13267329, CEP57 rs35793328, PCGF2 rs1985352 and MC4R rs66922415. Furthermore, several genes, many of which are involved in immune system processes, were significantly enriched with differentially methylated sites associated with LMI. Shorter telomeres were also associated with both sarcopenia and frailty. Notably, a significant relationship was observed between telomere length and methylation levels in genes related to lifestyle traits and the risk of developing these conditions. These findings provide new insights into the biological mechanisms underlying sarcopenia and frailty, underscoring the important roles of genetic and epigenetic factors in their pathogenesis among older adults. - Source: PubMed
Publication date: 2025/09/27
Ginevičienė ValentinaPranckevičienė ErinijaUrnikytė AlinaJurkūnaitė LauraGutauskaitė KristijonaDadelienė RūtaKilaitė JustinaJamontaitė Ieva EglėMastavičiūtė AstaAhmetov Ildus IAlekna Vidmantas