Kcnip3 antibody - middle region (ARP32620_P050)
- Known as:
- Kcnip3 (anti-) - middle region (ARP32620_P050)
- Catalog number:
- arp32620_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Kcnip3 antibody - middle region (ARP32620_P050)
Related genes to: Kcnip3 antibody - middle region (ARP32620_P050)
- Gene:
- KCNIP3 NIH gene
- Name:
- potassium voltage-gated channel interacting protein 3
- Previous symbol:
- CSEN
- Synonyms:
- DREAM, KCHIP3
- Chromosome:
- 2q11.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-05-24
- Date modifiied:
- 2016-10-05
Related products to: Kcnip3 antibody - middle region (ARP32620_P050)
Related articles to: Kcnip3 antibody - middle region (ARP32620_P050)
- Sialylation is a crucial glycosylation modification of eukaryotic cell surface proteins. Tumor cell growth, immune evasion, and drug resistance are driven by excessive sialylation. However, the expression levels of genes associated with sialylation, prognostic value, and impact on the response to immunotherapy in brain tumors remain unclear. This study hypothesized that sialylation-related genes could serve as grouping genes to identify 20 significant genes for predicting the survival outcomes of patients with brain tumors and their responsiveness to immune checkpoint inhibitors. - Source: PubMed
Publication date: 2025/12/09
Zhu GuidongLiu YanLiu RuiXin GuoqiangZhang ChengkeWang Chengwei - Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response. To this end, we undertook a large-scale proteomic study in well-phenotyped cohorts to identify biomarker candidates of ALS disease state and disease progression. - Source: PubMed
Publication date: 2025/09/29
Dergai OleksandrWuu JoanneKoziczak-Holbro MagdalenaMalaspina AndreaGranit VolkanHernandez Jessica PCooley AnneSachdev RuchikaYu LiliBidinosti MichaelFlotte LudivineNash MarkJennings Lori LBerry James DBruijn Lucie IBrachat SophieBenatar Michael - Western diets and social subordination are associated with increased risk of cardiovascular disease. In this study, we investigated the impact of Western versus Mediterranean diets and social status on atherogenesis and arterial transcriptional profiles in a 30-month randomized study in middle-aged, cynomolgus monkeys (). Atherosclerosis (intimal area) in the left anterior descending (LAD) coronary artery was higher in the Western diet group compared to the Mediterranean diet group ( = 5.25, = 0.03). There was no effect of diet on intimal lesion size in the iliac and carotid arteries ( > 0.05). Diet altered the transcriptome in iliac arteries; at an FDR threshold of 0.05, seven transcripts were upregulated (, and ENSMFAG00000052859), and 13 transcripts were downregulated (, , and ) in the Western compared to the Mediterranean diet cohort. These genes are associated with endothelial dysfunction, smooth muscle proliferation and migration, angiogenesis, and abnormal extracellular matrix (ECM) dynamics. In addition, two transcripts (ENSMFAG00000064154 [LncRNA] and ENSMFAG00000057515 [small nucleolar RNA U13]) were downregulated in subordinate monkeys relative to their dominant counterparts (FDR < 0.05). There was no effect of diet on the carotid artery transcriptome, but we did identify significant social status effects: Eleven transcripts were upregulated (, KCNIP3, ENSMFAG00000059809 [LncRNA], and ENSMFAG00000053865 [secreted protein A0A7N9CS45]), and seven transcripts were downregulated (, and ENSMFAG00000050714 [LncRNA]) in subordinate relative to dominant monkeys. These alterations were associated with dysregulated vascular tone and smooth muscle contractility, apoptosis, and abnormal ECM dynamics. These findings demonstrate differential effects of diet composition and social status depending on arterial sites. The effects of Western diet were observed primarily in the coronary and iliac arteries, whereas social status differences were observed primarily in the carotid arteries. Our results demonstrate that Western diets and social subordination have adverse, yet distinct and tissue-specific impacts on arterial atherogenesis and transcriptional profiles, highlighting the interplay between diet, social hierarchy, and vascular health. - Source: PubMed
Publication date: 2025/07/10
Abusheikha Aya JamalJohnson Corbin S CSnyder-Mackler NoahZimmerman Kip DNegrey Jacob DChiou Kenneth LFrye Brett MHoward Timothy DShively Carol ARegister Thomas C - Uveal melanoma (UM) is a primary intraocular malignancy with a high-risk of metastasis. Currently, there are no studies that construct prognostic models based on immune-related molecular subtypes. We performed unsupervised clustering of immune cell infiltration matrices based on the the cancer genome atlas-uveal melanoma (TCGA-UVM) dataset, identifying 2 clusters with distinct expression patterns of immune checkpoint and immune activation related genes. gene ontology/Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that genes in the immune-related gene modules identified by WGCNA were associated with immune activity and cell proliferation. Using Cox and LASSO regression analysis based on the immune-related gene modules to construct a prognostic model. The prognostic model was validated in external datasets of Gene Expression Omnibus (GEO) database. We constructed a prognostic model comprising genes S100A4, KCNIP3, PARP8, ORAI2, MMP12, ISG20, MMP9, and CEBPB. The model stratified patients into high and low-risk groups, with the high-risk group showing poorer prognosis. The model's predictive accuracy was validated with the AUC values exceeding 0.8 for 1-year, 3-year, and 5-year survival rates and confirmed in external datasets GSE22138 and GSE84976. Differential gene analysis between risk groups highlighted the association with immune response and cell proliferation functions. The CEBPB gene in the model played crucial roles in tumor progression. In vivo and in vitro experiments validated the impact of CEBPB on the biological functions of UM. Experiments in UM cells revealed that CEBPB promoted cell proliferation, migration and invasion, as well as suppressing apoptosis, indicating its potential as a therapeutic target. The prognostic model based on 8 immune-related genes effectively predicted the survival outcomes of UM. Knockdown of CEBPB significantly reduced the progression of UM, suggesting that it could be a potential therapeutic target for UM. - Source: PubMed
Tao YulinPeng YiruiZhu HaiboXiong MinqiZhou QiongOuyang Jun - Rheumatoid arthritis (RA) is a chronic inflammatory disorder with complex etiologies involving immune responses and circulating proteins. This study investigates the causal relationships between antibody immune responses, plasma circulating proteins, and the development of RA using Mendelian Randomization (MR) analysis; A two-sample and multivariate MR analysis was conducted to explore the mediating causal relationship between 46 antibody immune responses and RA through 4,907 plasma circulating proteins. Genetic variations were utilized as instrumental variables (IVs) to infer causality, ensuring that they met the assumptions of relevance, independence, and exclusion restriction. Data were sourced from the FinnGen R10 dataset, UK Biobank, and the SomaScan platform, providing a robust foundation for the analysis. Statistical methods including IVW, weighted median, and mode-based approaches were employed, complemented by sensitivity analyses to ensure the robustness of the findings; The study identified significant causal relationships between six antibody immune responses and RA, with three specific responses-Epstein-Barr virus EBNA-1, Epstein-Barr virus ZEBRA, and Anti-polyomavirus 2 IgG seropositivity-showing strong associations. However, reverse causality was detected for EBNA-1 and ZEBRA, leading to their exclusion from further analysis. Additionally, 12 plasma circulating proteins were found to have significant causal relationships with RA, with KCNIP3 emerging as a key protective factor. Multivariate MR analysis revealed that KCNIP3 mediates the relationship between Anti-polyomavirus 2 IgG seropositivity and RA, suggesting a potential protective mechanism. This study highlights the intricate relationships between specific antibody responses, circulating proteins, and RA risk. The findings suggest that certain proteins, particularly KCNIP3, may mediate the effects of immune responses on RA development, offering potential targets for therapeutic intervention. - Source: PubMed
Publication date: 2025/05/14
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