ZNF385 antibody - N-terminal region (ARP32542_P050)
- Known as:
- ZNF385 (anti-) - N-terminal region (ARP32542_P050)
- Catalog number:
- arp32542_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF385 antibody - N-terminal region (ARP32542_P050)
Related genes to: ZNF385 antibody - N-terminal region (ARP32542_P050)
- Gene:
- ZNF385A NIH gene
- Name:
- zinc finger protein 385A
- Previous symbol:
- ZNF385
- Synonyms:
- DKFZp586G1122, Hzf, ZFP385
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-28
- Date modifiied:
- 2015-05-18
Related products to: ZNF385 antibody - N-terminal region (ARP32542_P050)
Related articles to: ZNF385 antibody - N-terminal region (ARP32542_P050)
- To investigate the effects of chrysotile asbestos exposure on ribosomal DNA (rDNA) copy number variation and DNA damage response (DDR) in human pleural mesothelial cells (MeT-5A) . In April 2024 MeT-5A cells were exposed to chrysotile asbestos at doses of 2.5 μg/cm(2), 5 μg/cm(2) once a week for four weeks, and the cells were collected at weeks 1 and 4 (P1 and P7). The 45S rDNA copy number, 5S rDNA copy number, ACER2, PA2G4, and ZNF385A mRNA expression were determined by quantitative real-time PCR (qPCR) assay. Cell cycle, apoptosis, and DNA damage in the cells were detected using a Muse cell analyzer. The data were statistically anayzed using SPSS 24.0 software. Measurement data conforming to normal distribution were expressed as mean±standard deviation. One-way analysis of variance was used for comparisons among multiple groups, and the least significant difference () tset was used for further pairwise comparisons. Compared with the control group, the 45S and 5S rDNA copy number in the 5 μg/cm(2) exposed group increased at both P1 and P7 generations (<0.05). Compared with the control group, the mRNA expression level of the nucleolar protein ACER2 decreased in the chrysotile asbestos exposed groups at both P1 and P7 generations (<0.05), while the mRNA expression level of ZNF385A increased in the 5μg/cm2 exposed group (<0.05). The mRNA expression level of PA2G4 increased in the chrysotile asbestos exposure group at P7 (<0.05) but decreased in the exposure group at P1 (<0.05). Compared with the control group, the early, late and total apoptosis rates in the chrysotile asbestos exposure groups showed statistically significant differences at different time points (<0.05). Compared with the control group, the proportion of cells in the G0/G1 phase decreased in the chrysotile asbestos exposure group at P7 (<0.001), while the proportion of cells in the S phase increased (<0.05), and the proportion of G2/M phase increased in the 5 μg/cm2 exposure group (<0.05), with statistically significant differences. Compared with the control group, the DNA double-strand break rate in the exposure groups at P1 and P7 and the H2A.X phosphorylation rate in the exposed group at P7 increased, with statistically significant differences (<0.05) . Chrysotile asbestos exposure caused changes in rDNA copy number and mRNA expression levels of related nucleolin genes in Met-5A cells, inducing apoptosis, cell cycle arrest, and DNA damage. - Source: PubMed
Su XLi Y XLiu J QHuang JJiang Z QLou J L - Air pollution is associated with Alzheimer's disease (AD), and the susceptibility of AD from air pollution may be affected by genetic characteristics, but the underlying mechanisms remain unknown. - Source: PubMed
Publication date: 2026/01/23
Ran ShanshanZhang JingyiCai MiaoChen LanQian ZhengminTian FeiWu GanBoyd Ri'ennaMcMillin Stephen EdwardZeng Huai-CaiYang YinLin Hualiang - This study utilized TCGA database to explore the role of m6A modification and immune infiltration in AML. Through unsupervised clustering and WGCNA analysis, 8 hub genes were identified, and a risk model with EHBP1L1 and ZNF385A was established using LASSO regression. A nomogram incorporating hub gene risk score and age showed satisfactory prognostic prediction. External validation of GEO confirmed the model's effectiveness. TME analysis revealed correlations with monocytes and Treg cells, while immune checkpoints and HLA genes were associated with risk scores. Drug sensitivity analysis suggested potential responses to specific chemotherapy drugs. TIDE analysis indicated reduced ICI treatment benefit in high-risk patients. RT-qPCR validations revealed the significance of prognosis and risk stratification of ZNF385A. The noticeable trend of EHBP1L1 was observed. In addition, the accurate predictive capability of the risk model has been validated by clinical samples. Therefore, the risk model enables a quantitative evaluation of disease severity and progression risk in AML patients, based on their clinical and biological characteristics. This precise prediction not only informs treatment decisions but also guides the selection of chemotherapy regimens, overall improving patient outcomes. - Source: PubMed
Publication date: 2025/11/03
Bai YanliangNan HuijieWang LijieYang PeiyaoCui YabinXu JinhuiShi MingyueChen Yuqing - Double-stranded RNA (dsRNA) binding proteins (dsRBPs) play crucial roles in various cellular processes, especially in the innate immune response. Comprehensive characterization of dsRBPs is essential to understand the intricate mechanisms for dsRNA sensing and response. Traditional methods have predominantly relied on affinity purification, favoring the isolation of strong dsRNA binders. Here, we adopt the proteome integral solubility alteration (PISA) workflow for characterizing dsRBPs, resulting in the observation of 18 known dsRBPs and the identification of 200 potential dsRBPs. Next, we focus on zinc finger protein 385 A (ZNF385A) and discover that its knockout activates the transcription of interferon-β in the absence of immunogenic stimuli. The knockout of ZNF385A elevates the level of endogenous dsRNAs, especially transcripts associated with retroelements, such as short interspersed nuclear element (SINE), long interspersed nuclear element (LINE), and long terminal repeat (LTR). Moreover, loss of ZNF385A enhances the bioactivity of 5-Aza-2'-deoxycytidine (5-AZA-CdR) and tumor-killing effect of NK cells. Our findings greatly expand the dsRBP reservoir and contribute to the understanding of cellular dsRNA homeostasis. - Source: PubMed
Publication date: 2025/04/11
Jiang NaYang HekunLei YiQin WeidaXiong HuifangChen KuanMei KunrongLi GongyuMu XinChen Ruibing - Recently, oxidative stress and inflammatory responses have been shown to directly impact tumor growth and the tumor microenvironment (TME). However, more research is necessary to fully understand the relationship between oxidative stress and inflammatory responses and colorectal cancer (CRC). - Source: PubMed
Publication date: 2025/03/10
Guo YaqiShang ShipengLiang LeileiLiu Enrui