SEC14L2 Antibody - C-terminal region (ARP32518_P050)
- Known as:
- SEC14L2 Antibody - C-terminal region (ARP32518_P050)
- Catalog number:
- arp32518_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SEC14L2 Antibody - C-terminal region (ARP32518_P050)
Related genes to: SEC14L2 Antibody - C-terminal region (ARP32518_P050)
- Gene:
- SEC14L2 NIH gene
- Name:
- SEC14 like lipid binding 2
- Previous symbol:
- C22orf6
- Synonyms:
- TAP, SPF, KIAA1186, KIAA1658, TAP1
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-12
- Date modifiied:
- 2016-01-18
Related products to: SEC14L2 Antibody - C-terminal region (ARP32518_P050)
Related articles to: SEC14L2 Antibody - C-terminal region (ARP32518_P050)
- Immune stimulation or escape are critical factors determining the survival of malignancies, including oral squamous cell carcinoma (OSCC) and head and neck SCC (HNSCC). CD24 (CD24A in mice) is a glycoprotein anchored to cell membranes, modulating macrophages' immune responses, cell interaction, tumorigenesis, and stemness. However, its roles in the OSCC pathogenesis are still controversial. The modulation of CD24 on the oncogenicity and immunity of OSCC were investigated in this study. - Source: PubMed
Publication date: 2025/08/22
Chang Shi-RouChou Chung-HsienLiu Chung-JiChang Kuo-WeiPan Jian-HuaYen Sheng-LinLin Shu-Chun - To investigate the biological behavior, differentiation ability, and differential gene expression of lymph node mesenchymal stem cells (MSCs) in patients with diffuse large B-cell lymphoma (DLBCL) and reactive lymphoid hyperplasia (RLH), providing a theoretical basis for clinical chemotherapy resistance. - Source: PubMed
Ma Yu-ShuoLiu Zhi-HeSun YangZhang Yu-HangWang Wen-QiuWang Li-ShengZhao Xia - : Previous proteomic studies provided valuable information about cataracts, but unclarified issues, such as sex and ethnicity-associated differences, remain. This study aimed to provide additional data on cataract-related proteins regarding age, sex, and cataract type. : Twenty-six female and seven male Turkish cataract patients were screened for visual acuity and dysfunctional lens index. A nano-LC-MS/MS system and Progenesis QI software v3.0 were used for protein identification and quantification. The remaining data were evaluated with SPSS Version 29.0 software. : Proteins that showed age-associated changes were mainly involved in cytoskeletal organization. A glyoxalase enzyme, caveolin 1, and HS90B were lower, and RAB8B and ATP6V1B1 were higher in lenses in women. Proteins with lower levels in cataractous lenses than in transparent lenses included filensin and phakinin, concurrent with previous publications, and LCTL, GDI, HSPB1, and EIF4A2, not reported before. Corticonuclear cataracts constituted the only group showing depletions in putatively protective proteins, while the cortical type was the least influenced. ANXA1 and DNHD1 positively, and TCPD, SEC14L2, and PRPS1 proteins negatively correlated with visual acuity. : This study revealed cataract-related proteins concurrent with earlier studies and new ones hitherto unreported. Despite the low number of patients investigated, the results merit further research, as these new proteins are highly likely to be involved in cataractogenesis. - Source: PubMed
Publication date: 2025/07/04
Cosar BanuNefesoglu Mustafa SehvarAltinoz Meric AAkgun EmelSahin BetulBaykal AhmetSerteser Mustafa - The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild-type (WT) isolates was enabled by the expression of SEC14L2 and by inhibitors targeting deleterious host factors. Here, we aimed to optimize cell culture models to allow infection with HCV from patient sera. We used Huh7-Lunet cells ectopically expressing SEC14L2, CD81, and a GFP reporter with nuclear translocation upon cleavage by the HCV protease to study HCV replication, combined with a drug-based regimen for stimulation of non-modified wild-type isolates. RT-qPCR-based quantification of HCV infections using patient sera suffered from a high background in the daclatasvir-treated controls. We therefore established an automated image analysis pipeline based on imaging of whole wells and iterative training of a machine learning tool, using nuclear GFP localization as a readout for HCV infection. Upon visual validation of hits assigned by the automated image analysis, the method revealed no background in daclatasvir-treated samples. Thereby, infection events were found for 15 of 34 high titer HCV genotype (gt) 1b sera, revealing a significant correlation between serum titer and successful infection. We further show that transfection of viral RNA extracted from sera can be used in this model as well, albeit with so far limited efficiency. Overall, we generated a robust serum infection assay for gt1b isolates using semi-automated image analysis, which was superior to conventional RT-qPCR-based quantification of viral genomes. - Source: PubMed
Publication date: 2024/11/30
Schäfer NoemiRothhaar PaulHeuss ChristianNeumann-Haefelin ChristophThimme RobertDietz JuliaSarrazin ChristophSchnitzler PaulMerle UtaPérez-Del-Pulgar SofíaLaketa ViborLohmann Volker - Inhibiting cholesterol metabolism has shown great potential in non-small cell lung cancer (NSCLC). However, the regulatory mechanism of the lipid metabolism key factor Sect. 14-like lipid binding 2 (SEC14L2) in NSCLC remains unclear. This study investigates the effects of differentially expressed genes related to cholesterol metabolism on the development of NSCLC. - Source: PubMed
Publication date: 2024/12/18
Zhou QianhuiLi DianwuLiang YanchaoLong YunzhuLiu Yi