PAX7 antibody - N-terminal region (ARP32392_P050)
- Known as:
- PAX7 (anti-) - N-terminal region (ARP32392_P050)
- Catalog number:
- arp32392_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PAX7 antibody - N-terminal region (ARP32392_P050)
Related genes to: PAX7 antibody - N-terminal region (ARP32392_P050)
- Gene:
- PAX7 NIH gene
- Name:
- paired box 7
- Previous symbol:
- -
- Synonyms:
- Hup1
- Chromosome:
- 1p36.13
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-20
- Date modifiied:
- 2014-11-18
Related products to: PAX7 antibody - N-terminal region (ARP32392_P050)
Related articles to: PAX7 antibody - N-terminal region (ARP32392_P050)
- Skeletal muscle regeneration is mediated by skeletal muscle stem cells, known as satellite cells. Satellite cell proliferation is regulated by various secreted factors, including exercise-induced cytokines. Renalase is a protein that promotes cell proliferation through activation of intracellular signaling pathways in tumor cells. However, the role of renalase in satellite cell proliferation remains unclear. This study aimed to elucidate the role of renalase in satellite cell proliferation. - Source: PubMed
Publication date: 2026/04/17
Kato YuriTokinoya KatsuyukiAoki KaiTakekoshi Kazuhiro - Recently, a distinct, bland spindle cell neoplasm with rhabdomyoblastic phenotype, and VGLL3 rearrangement has been described. These tumors have a striking predilection for the head and neck area and so far, followed an indolent course. It remains unclear whether these tumors are best classified as true rhabdomyosarcomas. There are 11 reports of such tumors with limited follow-up. Here, we report an additional case with local recurrence, long-term follow-up and spatial profiling. The tumor occurred in the right buccal mucosa/oral commissure of a 47-year-old man. On clinical examination, the mass was firm, measuring ~1.5 cm. Biopsy and subsequent wedge excision were performed. Histologically, the tumor was composed of bland, small, spindle to ovoid cells, arranged in short fascicles and vaguely storiform architecture. The tumor cells diffusely infiltrated into skeletal muscle. There was a background of inflammatory cells including small lymphocytes and histiocytes. Neoplastic cells were positive for SMA, demsin, PAX7, myogenin and MyoD1. Whole transcriptome sequencing revealed a TCF12::VGLL3 fusion. Digital spatial profiling (DSP) identified pan-AKT expression, differential expression in the MAPK pathway, and revealed that the tumor attracted a dense T-cell rich inflammatory infiltrate. The patient had a lesion in the same location 6 years prior that underwent incisional biopsy, showed intense inflammatory infiltrate, and was interpreted as benign. FISH for VGLL3 on this tissue was positive for rearrangement. No additional adjuvant treatment was given, and the patient is alive without disease, 8 months after the major resection. Long term follow-up of 6 years with only local recurrence lends further support to the notion that these neoplasms are a class of indolent/low-grade rhabdomyoblastic tumors that are biologically and clinically distinct from fully malignant spindle cell rhabdomyosarcomas. - Source: PubMed
Dashti Nooshin KChakraborty DebopriyaSadanandappa Madhumala KDehner Carina AZhang Paul JPaydarfar Joseph ATafe Laura J - Biologically representative three-dimensional (3D) skeletal muscle models are required to understand the mechanisms underpinning muscle disease. The primary aim of this systematic review is to evaluate the current literature on 3D skeletal muscle models under tension. Its secondary aim is to explore injury mechanisms and generate a novel Core Outcome Set (COS) for reporting of such models. In vitro studies that utilised any skeletal muscle cell types cultured with an anchor system imposing axial strain were eligible for inclusion. A modified Delphi approach using corresponding authors of included studies was then developed to obtain a COS. This systematic review was reported in compliance with the PRISMA 2020 checklist. 37 articles were included. Of these, 7 articles induced an injury in their model. Cell lines used were both human and animal. Immunohistochemical testing on models revealed greatest concordance for myosin heavy chain (MHC), alpha actinin, and Pax7 as a means of demonstrating striated muscle. The final COS agreed on multiple reporting criteria for the validation of models based on morphology, phenotype and function. This systematic review summarises the current literature and has developed core outcome reporting for models of 3D skeletal muscle that impose axial strain. - Source: PubMed
Publication date: 2026/04/14
Bhanot Kunal Thurley NealCleveland Robin OMimpen JoletSnelling Sarah J BRickard RoryStaruch Robert - SummaryMyogenic precursor cells within skeletal muscles are responsible for the maintenance of skeletal muscle over a lifetime. Neurotrophic and growth factors play critical roles in this maintenance and in responses of myogenic precursor cells. Both glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) play roles in the maintenance and/or development of strabismus, yet few studies have examined their roles in the control of myogenic precursor cell proliferation and differentiation. Two populations of myogenic precursor cells were isolated from extraocular and leg muscle by fluorescence-activated cell sorting: EECD34 cells, largely PITX2-positive, and PAX7-positive cells. Cultures were treated with GDNF or CNTF and processed immunohistochemically to determine proliferation and differentiation rates. Neither GDNF nor CNTF affected cell proliferation rates for either muscle. Both treatments impacted cell differentiation by increasing multinucleated cell number, with TA-derived precursor cells producing cells containing large numbers of nuclei and EOM-derived precursor cells producing shorter multinucleated fibers with fewer nuclei. These differences may explain the presence of extremely short myofibers within normal adult EOM compared with limb muscle. As GDNF and CNTF are downregulated in strabismic muscles, data suggest that myofiber length homeostasis may be disrupted in strabismic EOM and suggest possible approaches for strabismus treatment. - Source: PubMed
Publication date: 2026/04/13
Winker Austin JJohnson Laura LMcLoon Linda K - Transient cell states that precede and support human myogenic lineage commitment, and the intrinsic and extrinsic signals that control them, remain poorly defined in vitro. Here, we used longitudinal single-nucleus profiling, together with a SIX1:H2B-GFP hPSC reporter for lineage tracing, resolved previously uncaptured transient intermediates and sequential waves of human myogenesis across differentiation and . We show that hPSC-directed myogenesis gives rise in parallel to paraxial mesoderm and a transient PAX8+ intermediate mesoderm population that forms a 3-dimensional pre-myogenic niche supporting the PAX3-to-PAX7 myogenic progenitor transition. LIANA+ analysis further identified a temporally restricted BMP7-BMPR1B interaction, together with laminin-linked signaling, between PAX8+ niche cells and skeletal muscle progenitors before commitment. We further show that dynamic SIX1 cofactor switching, including EYA3 activity, is required for PAX3-to-PAX7 progression, and that disruption of this program compromises multi-lineage niche integrity. Together, these findings define how transient niche populations and intrinsic regulatory networks coordinate early human myogenic lineage progression and provide a human in vitro platform to study parallel intermediate and paraxial mesoderm development during myogenesis. - Source: PubMed
Publication date: 2026/03/31
Jaime Olga GBazan Katherine FLi AngelaDeai Asja ALakatos AnitaHicks Michael R