Gps1 Antibody - N-terminal region (ARP32354_P050)
- Known as:
- Gps1 Antibody - N-terminal region (ARP32354_P050)
- Catalog number:
- arp32354_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Gps1 Antibody - N-terminal region (ARP32354_P050)
Related genes to: Gps1 Antibody - N-terminal region (ARP32354_P050)
- Gene:
- GPS1 NIH gene
- Name:
- G protein pathway suppressor 1
- Previous symbol:
- -
- Synonyms:
- COPS1, CSN1
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-10
- Date modifiied:
- 2014-11-19
Related products to: Gps1 Antibody - N-terminal region (ARP32354_P050)
Related articles to: Gps1 Antibody - N-terminal region (ARP32354_P050)
- Penile squamous cell carcinoma (PSCC) is rare, but a biologically aggressive malignancy. Recent comprehensive genomic profiling (CPG) efforts revealed the underlying genomic landscape of PSCC, identifying , , , , , and as frequently altered genes with potential roles in penile oncogenesis. In addition, recurrent mutations encoded in the gene have been observed in 7.4% of cases in a particular PSCC cohort. Functional studies demonstrated loss of function due to GPS1 Exon 9 missense mutations, proposing a possible role for these alterations as oncogenic driver events in PSCC. However, no other study confirmed the occurrence of gene mutations in PSCC. To elucidate the biological function of exon 9 mutations in PSCC pathogenesis, we utilized a comprehensive in-house cohort of 106 PSCC cases to explore their frequency and occurrence. Albeit, the previously reported mutations p.D382H and p.M384I were not observed in this large cohort of PSCC cases; this analysis, however, revealed two novel alterations in exon 9 in two (1.9%) of the analyzed cases: p.S372F (c.1115C>T) and p.A375D (c.1124C>A). This observation suggests that exon 9 sequence is a target of genetic alteration during PSCC pathogenesis. However, the non-recurrent nature of these alterations indicates that they are unlikely to represent oncogenic drivers in this disease. - Source: PubMed
Publication date: 2026/03/07
Tögel LarsElsner FelixWendler OlafGiedl JohannesGaisa Nadine TRichter GeorgCampean ValentinaBurger MaximilianWullich BerndBertz SimoneHartmann ArndtStoehr Robert - Based on prior evidence that red ginseng pectin GPS-1 ameliorates T2DM in rats and modulates gut microbiota, we report for the first time that GPS-1 interacts with the gut microbiota of T2DM rats, as demonstrated through an digestion-fermentation model. This study reports for the first time that GPS-1 is key to its anti-T2DM efficacy. Building on prior findings that GPS-1 modulates gut microbiota in diabetic rats, we employed an digestion-fermentation model to demonstrate how GPS-1 is metabolized by specific bacteria into beneficial metabolites (e.g., short-chain fatty acids), thereby clarifying the causal pathway through which GPS-1 improves host metabolic health. - Source: PubMed
Publication date: 2026/02/18
Sun XiwenLiu LiJiao WenboRen TingZhao RanTan ZiruiJiang ZiyeWang JingLi BoZhang XiaoyuJiao Lili - Plants compete for light by growing taller than their nearest competitors. This is part of the shade avoidance syndrome and is a response to an increase in far-red (FR) light reflected from neighboring leaves. The root responds to this shoot-sensed FR cue by reducing lateral root emergence. It is well established that the phytohormone gibberellic acid (GA) is involved in supplemental FR-induced shoot elongation. Although GA is transported from shoot to root, its role in regulating lateral root growth is unclear. Here, we chemically and genetically manipulated GA and showed that GA modulates the lateral root reduction induced by shoot-sensed FR enrichment in Arabidopsis (Arabidopsis thaliana). Using the FRET-based GA biosensor GPS1 (GIBBERELLIN PERCEPTION SENSOR 1), we observed detailed GA changes in the root upon shoot exposure to FR enrichment and upon GA application to the shoot. Supplying GA to the shoot mitigated the FR-enrichment-induced root phenotype, indicating a functional link between GA and changes in root development in response to shoot-sensed FR. The regulatory role of GA in root growth appears to be partially dependent on ELONGATED HYPOCOTYL 5 (HY5), a light-responsive transcription factor that regulates root growth. Shoot-to-root transported GA4 led to increased HY5 protein levels in the lateral root primordia. HY5 then repressed auxin signaling, which inhibited lateral root growth. Our data reveal a gibberellin-dependent mechanism through which above-ground FR light signals modulate lateral root growth, whereby phytohormone and light signaling coordinate development across spatial scales. - Source: PubMed
van Gelderen Kaspervan der Velde KyraKang Chia-KaiHollander JessyKoppenol AliciaPetropoulos OrfeasPrasetyaningrum PutriAkyüz TuğbaPierik Ronald - Self-limited delayed puberty (SLDP) is the most common cause of delayed puberty and exhibits high heritability, although few causal genes have been identified. This study aims to identify potential candidate genes associated with SLDP. - Source: PubMed
Rezende Raíssa CHe WenKaisinger Lena RLerario Antonio MSchafer Evan CKentistou Katherine ABarroso Priscila SAndrade Nathalia L MDantas Naiara C BCosta Elaine Maria FCellin Laurana PP S Quedas ElisangelaSeminara Stephanie BRey Rodolfo AGrinspon Romina PMeriq VeronicaOng Ken KLatronico Ana ClaudiaPerry John R BHoward Sasha RChan Yee-MingJorge Alexander A L - To explore non-small cell lung cancer (NSCLC) patients with new diagnosis of brain metastasis and construct Logistic regression model based on clinical pathology and prognosis score, and verify. - Source: PubMed
Publication date: 2025/03/07
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