PSMD11 antibody - N-terminal region (ARP32343_P050)
- Known as:
- PSMD11 (anti-) - N-terminal region (ARP32343_P050)
- Catalog number:
- arp32343_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PSMD11 antibody - N-terminal region (ARP32343_P050)
Related genes to: PSMD11 antibody - N-terminal region (ARP32343_P050)
- Gene:
- PSMD11 NIH gene
- Name:
- proteasome 26S subunit, non-ATPase 11
- Previous symbol:
- -
- Synonyms:
- S9, p44.5, MGC3844, Rpn6
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-02-19
- Date modifiied:
- 2016-10-05
Related products to: PSMD11 antibody - N-terminal region (ARP32343_P050)
Related articles to: PSMD11 antibody - N-terminal region (ARP32343_P050)
- Bladder cancer (BCa), a highly prevalent and aggressive tumor of the urinary system, typically exhibits poor clinical outcomes, particularly in advanced stages where therapeutic efficacy remains inadequate. A key characteristic of tumorigenesis, metabolic reprogramming, contributes substantially to cancer cell proliferation and metastatic progression. In the current investigation, phosphoglucomutase 3 (PGM3) was markedly overexpressed in BCa tissues, with elevated PGM3 expression strongly associated with unfavorable prognosis. Downregulation of PGM3 inhibited BCa tumor growth and metastasis by suppressing energy metabolism pathways, including glycolysis and oxidative phosphorylation (OXPHOS). Mechanistically, proteasome 26S subunit non-ATPase 11 (PSMD11) interacted with PGM3, reducing its ubiquitination and proteasomal degradation. Additionally, Parkin acted as a ubiquitinase, destabilizing PGM3, whereas PSMD11 competed with Parkin for PGM3 binding, thereby attenuating Parkin-mediated ubiquitination and stabilizing PGM3. Further analysis demonstrated that PSMD11 enhanced glycolysis and OXPHOS through PGM3, promoting BCa malignancy. Higher PSMD11 expression positively correlated with increased PGM3 expression. Collectively, these findings suggest that targeting the PSMD11/PGM3 axis could provide a promising therapeutic strategy for BCa. - Source: PubMed
Publication date: 2026/04/06
Cheng YuChen TaoZheng GuanghaoSong ZhenZhang GanXiao SongRao XuepengZeng Tao - To investigate the expression of the 26S proteasome non-ATPase regulatory subunit 11 (PSMD11) in gastric cancer and its impact on long-term patient prognosis. M Tumor and adjacent tissue samples were collected from a cohort of 94 gastric cancer patients treated at our hospital from January, 2016 to December, 2019. Immunohistochemistry was used to detect PSMD11 and Ki67 expression levels in the tissues, whose correlations with clinicopathological parameters and postoperative 5-year survival of the patients were analyzed. PSMD11 expression in gastric cancer was also analyzed using data from the GEPIA and UALCAN databases, while the KM-plotter database was used to predict 5-year survival rates. KEGG and GO enrichment analyses were employed to predict the biological functions and mechanisms of PSMD11. In cultured HGC-27 cells, the effects of PSMD11 knockdown and overexpression on cell migration, invasion and expressions of epithelial-mesenchymal transition (EMT) markers and TGF‑β/Smad pathway proteins were evaluated using scratch wound healing assay, Transwell assay, and Western blotting. - Source: PubMed
Zhou RenjieYang JingjingSong BowenChen XiaohuaWang LianWang YueyueZuo LugenZhu Bing - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease associated with high mortality. This study aimed to characterize serum proteomic signatures linked to adverse outcomes and to identify prognostic biomarkers with potential translational value for patient management. - Source: PubMed
Publication date: 2025/11/05
Zhao ChenxiGe ZiruoWang RanranXu YanliZhang TingyuJiang ZhoulingLiu LuLin LingChen Zhihai - Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviours with an aetiology involving genetic and environmental risk factors. Placental alterations, such as epigenetic DNA methylation and structural abnormalities, have been associated with ASD. Circular RNA (circRNA), covalently closed and highly stable molecules, play an epigenetic role by sequestering microRNA (miRNA) and modulating messenger RNA (mRNA) translation, forming posttranscriptional networks essential for gene expression. However, there is a lack of evidence in the literature regarding the involvement of circRNA, the placenta and ASD. To address this gap, the study aimed to map the interactions among circRNA, miRNA and mRNA, investigating their relevance to ASD and placental development using bioinformatics tools, such as circATLAS and miRTargetLink 2.0. The analysis identified 71 circRNA linked to ASD and 30 highly expressed in the placenta, which regulate pathways such as 'immune response,' 'gene transcription,' and 'replication,' and others previously associated with ASD, such as 'Notch and AKT signalling pathway'. Searches in the SFARI database revealed 11 relevant genes in the ASD group, nine in the placenta group and five shared genes (SRSF11, PSMD11, NOTCH1, CREBBP and TBL1X). Further analysis identified the interaction of the circRNA hsa-MAN1A2_0008 with miRNA associated with these genes. These findings suggest that highly expressed circRNA in the placenta regulate critical pathways for placental development and ASD aetiology, underscoring their role in linking placental alterations to ASD. - Source: PubMed
Braz-Barbosa BrayanGottfried CarmemSantos-Terra Júlio - The PSMD11 has been shown to be associated with the malignant progression and clinical outcomes of various carcinomas. However, the molecular mechanism of PSMD11 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we investigated the molecular mechanism of PSMD11 effect on the immune escape in NSCLC. - Source: PubMed
Publication date: 2025/09/26
Xi YongYang PengpengZeng JingZhou YundongPatel Akshay JShen WeiyuLiu XiaomingRajandram RetnagowriKrishnasamy Sivakumar