PITX1 antibody - middle region (ARP32340_P050)
- Known as:
- PITX1 (anti-) - middle region (ARP32340_P050)
- Catalog number:
- arp32340_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PITX1 antibody - middle region (ARP32340_P050)
Related genes to: PITX1 antibody - middle region (ARP32340_P050)
- Gene:
- PITX1 NIH gene
- Name:
- paired like homeodomain 1
- Previous symbol:
- BFT
- Synonyms:
- PTX1, POTX
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-27
- Date modifiied:
- 2016-01-27
Related products to: PITX1 antibody - middle region (ARP32340_P050)
Related articles to: PITX1 antibody - middle region (ARP32340_P050)
- Breast cancer is the leading cause of cancer-related deaths in women, primarily due to distant metastasis. Metabolic reprogramming plays a critical role in tumor growth and spread, but the metabolic mechanisms underlying metastasis in breast cancer remain unclear. The primary objective of this study is to identify molecular targets mediating breast cancer progression and to evaluate whether targeting the metabolic reprogramming represents a potential therapeutic strategy. - Source: PubMed
Publication date: 2026/04/22
Liu CongZhang ZhenyuFeng RonghuaZeng MengsiLi HuiZhu MeiZhuang LanLi ZongjuanWu Tao - Development of the vertebrate lower jaw depends on spatially precise cell fate decisions by cranial neural crest-derived cells (CNCCs) of the mandibular arch. From closer to the mouth (oral) to farther away (aboral), CNCCs adopt bone, cartilage, tendon, and stromal fates to shape the jaw skeleton and ensure proper connectivity to the musculature. How signaling pathways impact downstream transcriptional programs to generate distinct cell fates along the oral-aboral axis remains incompletely understood. Using photoconversion-based lineage tracing of CNCCs in zebrafish, we show that oral cells contribute to the lower jaw skeleton and aboral cells primarily to tendon, ligament, and stromal tissues. During embryogenesis, the oral domain is partitioned into lateral + and medial + subdomains distinct from an aboral +, + domain. Using pharmacological inhibition and transgenic misexpression, we find that Bmp signaling establishes aboral and expression, Fgf signaling oral-lateral expression, and Hedgehog signaling oral-medial expression. Analysis of mutants for , , and reveal that their oral-aboral expression domains are established independently of each other. We also identify enhancers regulating oral-aboral expression of and , with mutagenesis showing roles for Fgf-dependent ETS motifs in oral and Bmp-dependent E-box motifs in aboral enhancer activity, consistent with dependence of expression on the Bmp-dependent E-box factor Hand2. These findings reveal how triangulation of three major signaling pathways converge on distinct gene regulatory modules to establish distinct oral-aboral cell fate decisions in the developing jaw. - Source: PubMed
Publication date: 2026/04/08
Paulissen EricJunaid MunizaBrugger LylaChen Hung-JhenCrump J Gage - Talipes equinovarus (TEV), commonly known as clubfoot, is a congenital skeletal deformity characterized by abnormal three-dimensional positioning of the foot, ankle, and lower limb. This condition arises from developmental anomalies affecting multiple tissues in the lower limb, leading to disrupted alignment of foot and ankle joints. Without timely and appropriate intervention, TEV can result in persistent pain, structural deformities, and long-term functional impairments. - Source: PubMed
Publication date: 2026/02/03
Almohrij Saad - : The gene encodes a transcription factor that plays a crucial role in the development of the lower limbs, pelvis, and structures derived from the first branchial arch. Pathogenic variants in are associated with a limited spectrum of rare disorders, including congenital talipes equinovarus with or without long bone anomalies and/or mirror-image polydactyly, and Liebenberg syndrome. In 2020, a novel clinical phenotype, Mandibular-Pelvic-Patellar (MPP) syndrome, resulting missense variants, was proposed. : We report the fourth documented case of MPP syndrome worldwide, identified in a 17-year-old female patient presenting with congenital lower limb deformities, patellar aplasia, and micrognathia. Whole-genome sequencing revealed a heterozygous missense variant NM_002653.5: c.412A>C, p.(Lys138Gln). The clinical phenotype included knee flexion contractures and severe equinovarus and planovalgus foot deformities requiring multiple staged reconstructive surgical procedures. : This case supports recognition of MPP syndrome as a clinically and genetically distinct -related disorder. Our findings expand the phenotypic spectrum of MPP syndrome and suggest that severe congenital foot deformities represent a consistent and clinically relevant feature of this condition. - Source: PubMed
Publication date: 2026/01/29
Melnik EvgeniyaPetrova EkaterinaMarkova TatianaZabudskaya KsenyaDadali Elena - Human genetic variation influences all aspects of our biology, including the oral cavity, through which nutrients and microbes enter the body. Yet it is largely unknown which human genetic variants shape a person's oral microbiome and potentially promote its dysbiosis. We characterized the oral microbiomes of 12,519 people by re-analysing whole-genome sequencing reads from previously sequenced saliva-derived DNA. Human genetic variation at 11 loci (10 new) associated with variation in oral microbiome composition. Several of these related to carbohydrate availability; the strongest association (P = 3.0 × 10) involved the common FUT2 W154X loss-of-function variant, which associated with the abundances of 58 bacterial species. Human host genetics also seemed to powerfully shape genetic variation in oral bacterial species: these 11 host genetic variants also associated with variation of gene dosages in 68 regions of bacterial genomes. Common, multi-allelic copy number variation of AMY1, which encodes salivary amylase, associated with oral microbiome composition (P = 1.5 × 10) and with dentures use in UK Biobank (P = 5.9 × 10, n = 418,039) but not with body mass index (P = 0.85), suggesting that salivary amylase abundance impacts health by influencing the oral microbiome. Two other microbiome composition-associated loci, FUT2 and PITX1, also significantly associated with dentures risk, collectively nominating numerous host-microbial interactions that contribute to tooth decay. - Source: PubMed
Publication date: 2026/01/28
Kamitaki NolanHandsaker Robert EHujoel Margaux L AMukamel Ronen EUsher Christina LMcCarroll Steven ALoh Po-Ru