MMP19 antibody - N-terminal region (ARP32314_P050)
- Known as:
- MMP19 (anti-) - N-terminal region (ARP32314_P050)
- Catalog number:
- arp32314_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- MMP19 antibody - N-terminal region (ARP32314_P050)
Related genes to: MMP19 antibody - N-terminal region (ARP32314_P050)
- Gene:
- MMP19 NIH gene
- Name:
- matrix metallopeptidase 19
- Previous symbol:
- MMP18
- Synonyms:
- RASI-1
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-16
- Date modifiied:
- 2016-11-09
Related products to: MMP19 antibody - N-terminal region (ARP32314_P050)
Related articles to: MMP19 antibody - N-terminal region (ARP32314_P050)
- Acute coronary syndrome (ACS) and ischemic stroke are major life-threatening conditions caused by atherosclerosis. Although the mechanisms of atherosclerosis appear to be broadly similar across different vascular beds, growing evidence suggests that there are morphological and histological differences between coronary and carotid atherosclerosis. To identify disease-specific therapeutic strategies, we aimed to compare ACS and chronic coronary syndrome (CCS) in coronary artery disease, and symptomatic and asymptomatic carotid artery disease. - Source: PubMed
Publication date: 2026/03/17
Yoshida TakeshiEmoto TakuoYamamoto HiroyukiTakaya TomofumiSawada TakahiroMurphy Sarah LouiseShoda MitsuhikoNakamura KeisukeTaniguchi MasayukiSasaki NaotoFukuishi YutaToba TakayoshiOhkawa TakenaoFuruyashiki TomoyukiKawai HiroyaHirata Ken-IchiOtake HiromasaYamashita Tomoya - Matrix metalloproteinase (MMP) expression and function are highly context dependent, varying across physiological and pathological conditions. We previously documented the expression profiles of select MMPs in the ischemic brains of young male rodents. However, aging is a major risk factor for stroke in humans and is associated with vasculature alterations, increased oxidative stress, and elevated inflammation. In addition, sex differences have been reported in stroke incidence and severity. Despite this, the effects of age, sex, and species on brain MMP gene expression after cerebral ischemia/reperfusion (I/R) has not been systematically examined. Therefore, we investigated how age, sex, and species influence the mRNA expression of all known MMPs (22 total) in the brain following cerebral I/R. Moderate-to-severe neurological deficits were induced by transient middle cerebral artery occlusion (MCAO) followed by reperfusion in young and aged male and female C57BL/6 mice and in young male Sprague-Dawley rats. Brain tissue from the ipsilateral (ischemic) hemisphere was collected on post-MCAO day 1, and MMP mRNA levels were quantified by real-time PCR and expressed as fold change relative to the sham control group. Across species, MMP-3, MMP-8, MMP-12, MMP-13, MMP-19, MMP-20, and MMP-27 were upregulated in both rats and mice. Species-specific increases were also observed: MMP-1, MMP-7, MMP-9, MMP-14, MMP-21, and MMP-25 were upregulated only in rats, whereas MMP-10 was upregulated only in mice. The most strongly upregulated MMPs were MMP-12 in rats and MMP-3, MMP-10, and MMP-12 in mice. By contrast, MMP-15 and MMP-17 were downregulated in both species, whereas MMP-23 and MMP-24 were downregulated only in rats and mice, respectively. Within mice, MMP-3, MMP-10, MMP-12, MMP-19, MMP-20, and MMP-21 increased in both sexes and age groups, except for MMP-19 in aged males and MMP-21 in young males. MMP-14 increased only in females (young and aged), whereas MMP-27 increased only in males (young and aged). Notably, MMP-3, MMP-10, and MMP-12 were the three most highly upregulated MMPs in both male and female mice regardless of age. Overall MMP mRNA expression levels were higher in aged male mice and lower in aged female mice relative to sex-matched young mice. Among all MMPs examined, MMP-12 showed the most marked upregulation across species and, within mice, across age groups and sexes. Collectively, these findings demonstrate that brain MMP gene expression after cerebral I/R is modulated by age, sex, and species, underscoring the importance of incorporating these biological variables when targeting MMPs individually or in combination in preclinical rodent stroke models. - Source: PubMed
Publication date: 2026/02/26
Challa Siva ReddyBaker Isidra MVinayagam VisheshJackson Samantha NKhan NabeehaMada Sahil ReddyUnnam PavaniFornal Casimir AKlopfenstein Jeffrey DVeeravalli Krishna Kumar - To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression. - Source: PubMed
Robinson Amanda DPain Clare EMorgan Gabrielle ASanyal AnweshaChaparala SrilakshmiPachman Lauren MTorok Kathryn S - Sheep () exhibit significant diversity in adipose tissue deposition, which influences meat quality, environmental adaptation, and economic value. Tail fat, in particular, varies widely among breeds, yet the transcriptomic basis of this variation remains incompletely understood. This study aims to systematically compare the transcriptional profiles of five adipose depots across five sheep breeds to identify molecular mechanisms underlying fat deposition and tail phenotype divergence. - Source: PubMed
Publication date: 2026/01/17
Yu YiLiu SiruiYang JiXu Songsong - Lung cancer (LC), prostate cancer (PC), and breast cancer (BC) are the three most prevalent cancers that lead to bone metastasis (BoM). In this study, we conducted an integrated analysis of single-cell transcriptomic data from the primary tumors and BoM across PC, LC, and BC. We discover a novel subtype of tumor-associated macrophages (TAMs) that are positive both for matrix metalloproteinase 19 (MMP19) and receptor activator of nuclear factor-κB (RANK) expression (MMP19 RANK TAMs). MMP19 RANK TAMs demonstrate an increased level of M2 polarization and act as a critical driving factor for LC-BoM. MMP19 RANK TAMs are organized in a ring-like arrangement surrounding the tumor nests, constructing a barrier structure that impedes the infiltration of CD8 T cells into the tumor core in LC-BoM. RANKL inhibitor Denosumab has been shown to effectively reduce the level of M2 polarization, decrease the population of MMP19 RANK TAMs, and disrupt their barrier structure. Denosumab facilitates the infiltration of CD8 T cells into the interior of LC-BoM tissues. Based on this mechanism, we observed in both clinical cohorts and preclinical models that RANKL inhibitor can enhance the efficacy of immunotherapy in treating LC-BoM. - Source: PubMed
Publication date: 2026/01/01
Hu XianglinDu NanSong YanshaLang KeTong WanningYe QingrongLiu XuesiZheng HaoyuCheng MoJi YingzhengWu HaiboZhang MingheHe XinhongZhang YanLi XiaomengZhu YaoLi KunCai WeiluoYan WangjunHuang Wending