TBX21 antibody - N-terminal region (ARP31924_T100)
- Known as:
- TBX21 (anti-) - N-terminal region (ARP31924_T100)
- Catalog number:
- arp31924_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- TBX21 antibody - N-terminal region (ARP31924_T100)
Related genes to: TBX21 antibody - N-terminal region (ARP31924_T100)
- Gene:
- TBX21 NIH gene
- Name:
- T-box 21
- Previous symbol:
- -
- Synonyms:
- TBLYM, T-bet
- Chromosome:
- 17q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-29
- Date modifiied:
- 2015-02-24
Related products to: TBX21 antibody - N-terminal region (ARP31924_T100)
Related articles to: TBX21 antibody - N-terminal region (ARP31924_T100)
- CD4 T cells orchestrate antiviral immunity but can also drive immunopathology in hepatitis B virus (HBV) infection. Peripheral helper T (Tph) cells are implicated in extra-lymphoid inflammation, yet their functional roles during HBV infection remain elusive. - Source: PubMed
Publication date: 2026/04/15
Li Xiao-YuZhang PengZhu MengmengLv QiaolanLi JingZhang XiangyanCheng YongqianMeng FanpingZhang MinZhou Ming-JuWang You-YuanYu YingyingFeng JinChen Si-YuanWang Ming-LiJiao Yan-MeiFan XingSong Jin-WenXu RuonanZhen ChengShi MingWang Fu-ShengZhang Chao - Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their effector programs. Although Th cells produce acetylcholine (ACh) and express nicotinic acetylcholine receptors (nAChRs), the contribution of nAChRs to human memory Th function across central (Tcm) and effector (Tem) subsets is poorly defined. We examined the effect of nicotine and GTS-21, a compound previously described as targeting α7nAChR, on total memory Th cells and purified Tcm and Tem from healthy participants. Nicotine or GTS-21 diminished IFN-γ, IL-4, and IL-17A secretion, downregulated TBX21, GATA3, and RORC, and reduced NF-κB p65 phosphorylation in total memory Th cells. Disruption of CHRNA7 abolished nicotine-mediated suppression but did not eliminate the inhibitory effects of GTS-21. Within CCR7-defined subsets, nicotine and GTS-21 lowered Th1/Th2/Th17 frequencies in Tcm, but not in Tem. In purified subsets, nicotine suppressed IFN-γ, IL-4, IL-17A, IL-21, BCL6, and CD40L selectively in Tcm, whereas GTS-21 suppressed them in both Tcm and Tem. Collectively, nicotine engages an α7nAChR-dependent checkpoint that preferentially regulates Tcm responses, while GTS-21 exerts broader suppressive effects not fully explained by α7nAChR loss. This cholinergic checkpoint in Tcm may limit Tfh-associated help and pathogenic recall responses in immune-mediated disease. - Source: PubMed
Gholizadeh FatemehHajiaghayi MehriRahbari NiloufarChoi Jennifer SHeidt SamanthaComo AlexiaKazerouni MaryamKargar MelikaPinard-LaRoche AudeShih Steve C CDarlington Peter J - To identify serum diagnostic biomarker for damp-heat (DH) pattern in chronic liver diseases using transcriptomics and metabolomics. - Source: PubMed
Publication date: 2026/03/17
Pan Yu-QingHu Yi-YangZhang Bin-BinHu NaXin XinPeng Jing-HuaFeng QinZhao Yu - Neonatal regulatory T (Treg) cells in secondary lymphoid organs have greater proliferative capacity and more potent suppressive functions than adult Treg cells. However, the phenotypic and functional features of Tregs in neonatal nonlymphoid organs are not well understood. Our prior work demonstrated that thymus-derived Treg cells entering the neonatal mouse liver enhance immune tolerance and periportal liver maturation. Compared to splenic Treg cells, these hepatic Tregs have faster turnover and superior suppression of naïve T-cell proliferation. To further define this population, we conducted single-cell transcriptomic and immunophenotypic analyses of liver- and spleen-derived Tregs from neonatal and adult mice. Our analysis revealed a distinct T-box transcription factor Tbx21 (T-bet) effector Treg subset uniquely enriched in the neonatal liver. These cells possess liver-homing properties, clonal expansion of unique T-cell receptor (TCR) repertoires, and heightened suppressive activity. Interleukin-27 (IL-27) and interferon gamma (IFN-γ), cytokines highly expressed in the neonatal liver, play a critical role in promoting T-bet expression and the acquisition of an ectonucleoside triphosphate diphosphohydrolase 1 (CD39) C-X-C chemokine receptor type 3 (CXCR3) double-positive phenotype in Treg cells. Collectively, our findings characterize a liver-specific neonatal T-bet Treg population shaped by the hepatic microenvironment, highlighting its unique tissue-resident signature and immunoregulatory role. - Source: PubMed
Publication date: 2026/03/09
Yang LijunWang YujiaLi MingyangLian ZhexiongYin ZhinanHao JieSun XiuyuanJin RongGe Qing - Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with immune dysregulation, yet the mechanistic basis of this comorbidity remains poorly understood. Using the paternal 15q11-13 duplication (15q dup) mouse model of ASD, we identify that systemic dopamine deficiency is associated with impaired terminal maturation and effector function of natural killer (NK) cells. Functionally, dopaminergic stimulation promotes NK cell maturation and activity in a D1-like receptor-cAMP associated manner, accompanied by altered expression of the NK maturation-related transcription factor Tbx21. Notably, pharmacological activation of D1-like receptors enhances anti-tumor immunity and improves social behavior in an NK-dependent manner in 15q dup mice. Together, these findings support a dopaminergic neuroimmune framework in which systemic dopamine signaling is associated with innate immune regulation and immune-dependent behavioral phenotypes in the 15q dup mice. - Source: PubMed
Publication date: 2026/03/03
Chen XinranZhang XiangyanFeng JinZhang Chen