ABT1 antibody - N-terminal region (ARP31915_P050)
- Known as:
- ABT1 (anti-) - N-terminal region (ARP31915_P050)
- Catalog number:
- arp31915_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ABT1 antibody - N-terminal region (ARP31915_P050)
Related genes to: ABT1 antibody - N-terminal region (ARP31915_P050)
- Gene:
- ABT1 NIH gene
- Name:
- activator of basal transcription 1
- Previous symbol:
- -
- Synonyms:
- Esf2
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-23
- Date modifiied:
- 2017-05-26
Related products to: ABT1 antibody - N-terminal region (ARP31915_P050)
Related articles to: ABT1 antibody - N-terminal region (ARP31915_P050)
- Acinetobacter baumannii is a formidable multidrug-resistant pathogen prevalent in healthcare settings. Amid the escalating challenge of antimicrobial resistance, phage therapy has regained significant attention. This approach harnesses the natural predatory ability of bacteriophages to combat bacterial infections. - Source: PubMed
Publication date: 2026/02/26
Li XiaoxiaoLiu JiaxinLi HaoyuZhang WanlianWei HanqiSong ShihaoChen Xiangxiu - Bovine leukemia virus (BLV), a member of the Deltaretrovirus genus, causes enzootic bovine leukosis, leading to clinical outcomes that range from asymptomatic infection to malignant lymphoma. Host genetic factors significantly influence BLV susceptibility, proviral load (PVL), immune response, and disease progression. This mini-review synthesizes evidence on genetic polymorphisms in immune-related genes such as BoLA-DRB3, Tumor necrosis factor (TNF), and immunoglobulin loci, and examines novel findings from genome-wide association studies (GWAS). Beyond classical immune genes, recent GWAS have identified novel loci including SPATA16 (spermatogenesis associated 16), ABT1 (activator of basal transcription 1), IER3 (immediate early response 3), Adaptor Related Protein Complex 4 Subunit Beta 1 (AP4B1), Tripartite Motif Containing 45 (TRIM45), Patatin Like Phospholipase Domain Containing 1 (PNPLA1), and PRRC2A (proline-rich coiled-coil 2 A) that are implicated in transcriptional regulation, stress response, RNA processing, and intracellular transport, all of which may modulate viral replication and persistence. Understanding these genetic determinants provides new insights into host-virus interactions and offers opportunities for selective breeding strategies, biomarker development, and improved BLV control programs. - Source: PubMed
Publication date: 2025/11/17
Akbarin Mohammad MehdiFarjami ZahraÁlvarez Hugo Ramírez - Autism Spectrum Disorder (ASD) involves a multi-system interaction mechanism among genetics, immunity, and gut microbiota, yet its regulatory network remains undefined. This study conducted a meta-analysis on Genome-Wide Association Study data from four independent ASD cohorts to identify potential genetic loci. By integrating Polygenic Priority Score, brain region, and brain cell eQTL enrichment analyses, and combining summary-data-based Mendelian Randomisation (SMR) analyses of brain cis-eQTL and mQTL, bidirectional Mendelian Randomisation analyses of 473 gut microbiota, and SMR analysis of blood eQTL, SNPs such as rs2735307 and rs989134 with significant multi-dimensional associations were identified. These loci exert cross-tissue regulatory effects by participating in gut microbiota regulation, involving immune pathways such as T cell receptor signal activation and neutrophil extracellular trap formation, as well as cis-regulating neurodevelopmental genes (HMGN1 and H3C9P), or synergistically influencing epigenetic methylation modifications to regulate the expression of BRWD1 and ABT1. The cross-scale evidence chain constructed in this study provides a theoretical foundation for precision medicine research in ASD, holding promise to advance the development of innovative therapeutic strategies. - Source: PubMed
Publication date: 2025/10/29
Liao XingxingLong JunziWang XiannaHan KaiyueTang ZhiqingChen JiarouZhang YanZhang Hao - This study employs a dual-pronged approach, integrating retrospective cohort analysis with genetic methodologies, to elucidate the causal role of nightly short sleep in the pathogenesis of asthma and to unravel its underpinning biological mechanisms. - Source: PubMed
Fu ChongXu WeiZhang Yanping - Gene duplications are considered to be the major evolutionary resource of novel functions. The gene family is conserved in metazoan organisms from yeast to humans. Here we performed a search and characterization of homologs in the genus. Whereas in the majority of species this gene family is represented by only a single gene, in the and subgroups recurrent gene duplications arose, providing 47 homologous genes located on the X chromosome. To study the evolutionary history of duplicates, we performed phylogenetic, functional domain, and tissue-specific expression analyses. We revealed a male-specific and testis-biased transcription pattern of duplicated copies in and compared to ubiquitous expression of the parental gene. The amplification of 21 repeated paralogs within the heterochromatic piRNA cluster resulted in the ovarian-specific transformation of these repeats into piRNAs in In three species of the subgroup, genes evolved with domain diversification: in addition to RNA-binding ABT1-like domain preservation, all homologous proteins acquired expanded intrinsically disordered regions. By studying the duplicated copies of the family in , we offer insight into how novel gene functions emerge and are maintained, contributing to life's diversity and complexity. - Source: PubMed
Publication date: 2025/09/11
Davydova Elizaveta DKotov Alexei AChernizova Alina VYakovleva Ekaterina YuOlenina Ludmila V