RACGAP1 antibody - N-terminal region (ARP31905_T100)
- Known as:
- RACGAP1 (anti-) - N-terminal region (ARP31905_T100)
- Catalog number:
- arp31905_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- RACGAP1 antibody - N-terminal region (ARP31905_T100)
Related genes to: RACGAP1 antibody - N-terminal region (ARP31905_T100)
- Gene:
- RACGAP1 NIH gene
- Name:
- Rac GTPase activating protein 1
- Previous symbol:
- -
- Synonyms:
- MgcRacGAP
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-09
- Date modifiied:
- 2015-08-25
Related products to: RACGAP1 antibody - N-terminal region (ARP31905_T100)
Related articles to: RACGAP1 antibody - N-terminal region (ARP31905_T100)
- - Source: PubMed
Publication date: 2026/04/14
Zelleke Amen BekeleAzzo Joe DavidMoreno Jonathan DMann Douglas LCappola Thomas PChirinos Julio AJavaheri Ali - Cells actively maintain complex lipidomes that encompass thousands of lipids; however, many of the roles of these lipids remain unexplored. Specific interactions between lipids and membrane proteins are a likely reason for lipidome complexity. Here we report the development of a technique, named lipid-trap mass spectrometry (LTMS), to systematically study lipid-protein interactions directly captured from mammalian cells. LTMS uses immunoprecipitation of GFP-tagged proteins expressed in HeLa cells, followed by lipidomic analysis of lipids bound to the GFP-tagged protein. We applied LTMS to cell division to illustrate the technique. We chose this process because membranes regulate their lipid composition as they undergo major changes during cytokinesis, and many cytokinetic proteins, including RACGAP1 and ESCRT-III components CHMP4B and CHMP2A, are membrane-associated. Using LTMS, we found that RACGAP1 and CHMP4B associate with specific lipid species in dividing compared with non-dividing cells. We expand our understanding of lipid diversity during cell division and present a general approach to explore lipid-protein interactions to further our knowledge of the roles of lipids in mammalian cells. - Source: PubMed
Publication date: 2026/04/13
Paquola AndreaBenson Clare EDesale Smita EknathOzbalci CagakanStorck Elisabeth MTerry Stephen JRao Bhagyashree DasariNwite Kelechi NFerrentino FedericaEggert Ulrike S - Tissue inhibitor of metalloproteinase 3 (TIMP-3) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) and ADAM/ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family enzymes that regulate extracellular matrix (ECM) homeostasis. Because these enzymes play key roles in articular cartilage turnover, TIMP-3-mediated inhibition protects against cartilage degradation, a hallmark of osteoarthritis (OA), and has been explored as a therapeutic target. Nonetheless, unexpected detrimental effects of TIMP-3 on bone mass and structure have been reported in transgenic mice overexpressing TIMP-3 in cartilage. Mechanistically, TIMP-3 binds catabolic enzymes and blocks their active sites but also interacts with low-density lipoprotein receptor-related protein 1 (LRP-1) and sulfated proteoglycans in the ECM, processes that regulate its half-life through a balance between endocytosis and ECM retention and may influence cell signaling. - Source: PubMed
Publication date: 2026/03/11
Mengozzi ManuelaTowler BenKwabiah JordanRazmandeh FawadSimoes FabioMullen Lisa - Bisphenol A (BPA), a typical endocrine-disrupting chemical, is implicated in the pathogenesis of Polycystic Ovary Syndrome (PCOS); however, the underlying molecular mechanisms and pathophysiological processes remain unclear. This study aims to decipher molecular interactions between BPA and PCOS-related genetic networks, and to determine the combinatorial impacts of environmental pollutants on PCOS progression. - Source: PubMed
Publication date: 2026/03/02
Zhang YanLin YuanXiong XiumeiChen XiujuanLiu XiaoqingHuang Hailong - Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of challenges in early diagnosis and the limited sensitivity of conventional biomarkers. Therefore, reliable molecular tools for early detection, prognostic stratification, and individualized treatment predictions are urgently required. - Source: PubMed
Publication date: 2026/03/04
Nguyen Tan ThinhNguyen Thanh DatNguyen Phu Qui LeBui Phuong ThiNguyen Minh Nam