FOXR1 Antibody - N-terminal region (ARP31888_P050)
- Known as:
- FOXR1 Antibody - N-terminal region (ARP31888_P050)
- Catalog number:
- arp31888_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FOXR1 Antibody - N-terminal region (ARP31888_P050)
Related genes to: FOXR1 Antibody - N-terminal region (ARP31888_P050)
- Gene:
- FOXR1 NIH gene
- Name:
- forkhead box R1
- Previous symbol:
- -
- Synonyms:
- DLNB13, FOXN5
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-18
- Date modifiied:
- 2015-09-07
Related products to: FOXR1 Antibody - N-terminal region (ARP31888_P050)
Related articles to: FOXR1 Antibody - N-terminal region (ARP31888_P050)
- FOXR1 belongs to the large conserved F-box family of DNA binding transcription factors that are involved in various developmental processes and diseases. The gene is important for embryogenesis in a fish model, brain development in mammals, and human FOXR1 was shown to possess oncogenic properties when it is abnormally expressed as a fusion gene. Earlier work on Foxr1 expression in mouse and human suggested roles for the protein in embryogenesis and sexual reproduction. We generated a mouse gene deletion model that revealed an embryonic lethal phenotype with partial penetrance and normal fertility in persistent homozygous male mutants. The results suggest that Foxr1 is functionally redundant in adult male gonads but needed for normal early embryo development and post-natal viability. We discuss our results in the context of publicly available human and rodent genomic and genetic data. - Source: PubMed
Jamin Soazik PPetit Fabrice GKervarrec ChristinePrimig Michael - Foxr1 is a member of the evolutionarily conserved forkhead box (Fox) family of transcription factors, characterized by a winged-helix DNA-binding domain. We previously demonstrated that deletion in mice results in severe perinatal lethality, cortical thinning, and ventricular enlargement, indicating its essential role in survival and brain development. Here, we extend these findings by showing that knockout mice develop microcephaly accompanied by cortical and hippocampal hypoplasia at postnatal day 0 (P0). Cortical thinning is primarily driven by a significant reduction in layer 2/3 neurons, linked to impaired generation of later-born neurons. This reduction correlates with decreased proliferation of progenitors (Ki67- and Tbr2-positive cells) at embryonic day 16.5 (E16.5), a critical period for upper-layer neurogenesis. In the hippocampus, knockouts exhibit reduced area, and cell counts at P0, accompanied by increased proliferation (Ki67-positive cells), and elevated apoptosis (CC3-positive) at E16.5, suggesting broader disruptions in progenitor maintenance. Together, these findings suggest Foxr1 is an important regulator of progenitor dynamics and neuron production in cortical and hippocampal development. - Source: PubMed
Publication date: 2025/05/27
Waxman HannahKankkunen MarcusGupta AryaDowgiewicz MargoBeffert UweHo Angela - - Source: PubMed
Cordier FleurFerdinande LiesbethLoontiens SiebeVan der Meulen JoniVan Dorpe JoCreytens David - Composite hemangioendothelioma is a rare, locally aggressive, and rarely metastasizing vascular neoplasm which affects both children and adults. Recently, a number of gene fusions including YAP1::MAML2, PTBP1::MAML2, and EPC1::PHC2 have been detected in a small subset of cases with or without neuroendocrine expression. Herein, we present four additional cases with novel in-frame fusions. The cohort comprises two females and two males with a wide age range at diagnosis (24-80 years). Two tumors were deep involving the right brachial plexus and mediastinum, while the remaining were superficial (right plantar foot and abdominal wall). The size ranged from 1.5 to 4.8 cm in greatest dimension. Morphologically, all tumors had an admixture of at least two architectural patterns including retiform hemangioendothelioma, hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. The tumors were positive for endothelial markers CD31 (3/3), ERG (4/4), and D2-40 (1/4, focal), while SMA was expressed in 2/3 highlighting the surrounding pericytes. Synaptophysin showed immunoreactivity in 2/3 cases. One patient had a local recurrence after 40 months, while two patients had no evidence of disease 4 months post-resection. Targeted RNA sequencing detected novel in-frame fusions in each of the cases: HSPG2::FGFR1, YAP1::FOXR1, ACTB::MAML2, and ARID1B::MAML2. The two cases with neuroendocrine expression occurred as superficial lesions and harbored YAP1::FOXR1 and ARID1B::MAML2 fusions. Our study expands on the molecular spectrum of this enigmatic tumor, further enhancing our current understanding of the disease. - Source: PubMed
Publication date: 2023/09/02
Linos KonstantinosDermawan Josephine KPulitzer MelissaHameed MeeraAgaram Narasimhan PAgaimy AbbasAntonescu Cristina R - Natural menopause is an inevitable biological process with significant implications for women's health. However, the molecular mechanisms underlying menopause are not well understood. This study aimed to investigate the molecular and cellular changes occurring in the ovary before and after perimenopause. - Source: PubMed
Publication date: 2023/07/24
Liu QuanWei FangqinWang JiannanLiu HaiyanZhang HuaLiu MinLiu KailiYe Zheng