AKAP8L Antibody - C-terminal region (ARP31872_P050)
- Known as:
- AKAP8L Antibody - C-terminal region (ARP31872_P050)
- Catalog number:
- arp31872_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- AKAP8L Antibody - C-terminal region (ARP31872_P050)
Related genes to: AKAP8L Antibody - C-terminal region (ARP31872_P050)
- Gene:
- AKAP8L NIH gene
- Name:
- A-kinase anchoring protein 8 like
- Previous symbol:
- -
- Synonyms:
- NAKAP95, HAP95
- Chromosome:
- 19p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-18
- Date modifiied:
- 2015-11-17
Related products to: AKAP8L Antibody - C-terminal region (ARP31872_P050)
Related articles to: AKAP8L Antibody - C-terminal region (ARP31872_P050)
- Schizophrenia is a heterogeneous psychiatric disorder with diverse clinical manifestations and complex biological mechanisms, in which age-at-onset (AAO) critically influences disease trajectory. Patients with early-onset schizophrenia (EOS; AAO < 18 years) present with more pronounced neurodevelopmental deficits and poorer long-term outcomes compared to adult-onset (AOS) cases. Previous genetic research on AAO and EOS has primarily focused on candidate genes and genome-wide association studies (GWAS). DNA methylation, an epigenetic mechanism influenced by the interplay between environmental and genetic factors, remains understudied, especially in the Chinese population. Peripheral blood DNA from 120 schizophrenia patients (49 EOS, 71 AOS) was analyzed using the Infinium MethylationEPIC v2.0 array. Differential methylated analyses were conducted for both EOS-AOS dichotomous comparison and continuous AAO, with stringent adjustment for age, sex, smoking, and estimated cell proportions. At a suggestive significance threshold (p < 5 × 10), we identified 49 differentially methylated positions (DMPs) for EOS-AOS and 126 DMPs for AAO. Genes annotated to the identified DMPs included known schizophrenia and EOS-associated loci (such as ORMDL1, ANXA4, and TRRAP), as well as novel regions linked to cognitive function and neurodevelopment (such as AKAP8L, GPRC5C, and C4orf45). Enrichment analysis implicated key biological processes, including kinase signaling, cell cycle regulation, and microRNA pathways involved in apoptosis and oncogenesis. This study reveals novel differential DNA methylation patterns associated with EOS in the Chinese population and identifies key biological pathways potentially underlying its pathogenesis. - Source: PubMed
Publication date: 2026/02/10
Zhan NaLeung Perry B MZhong YuanxinWong Kenneth C YHui Tomy C KSo Hon-CheongSham Pak CWong Chloe C YLui Simon S Y - The association between early life exposure to smoking and the risk of inflammatory bowel disease (IBD) needs to be further verified, and the potential role of DNA methylation in the association is unclear. Through an integrated study design, this study demonstrates that maternal smoking during pregnancy (MSDP) is potentially associated with increased risk of IBD, Crohn's disease (CD), and ulcerative colitis (UC) in offspring. In addition, individuals who started smoking in adolescence have a higher risk of developing CD and IBD. Mechanistically, MSDP-associated DNA methylation alterations in ADCY7 (newborn), AKAP8L (newborn), TIGD7 (newborn), and TNF/LTA (across life stages) are significantly correlated with increased risk of CD in offspring; MSDP-induced DNA methylation changes in PRRT1 (newborn), AHRR (across life stages), and MYO1G (across life stages) show significant associations with UC risk in offspring. Notably, the alterations of DNA methylation status within AHRR, MYO1G, and TNF/LTA loci associated with smoking exposure are present throughout the life course. Collectively, MSDP may serve as an independent risk factor for IBD in offspring, and active smoking during adolescence may cause increased risk of developing CD and IBD. MSDP may contribute to IBD susceptibility by inducing persistent DNA methylation alterations at multiple developmental stages. - Source: PubMed
Publication date: 2026/01/11
Zhang HanZhao JianhuiChen JieMa XinyiZhou SiyunNoble AlexandraKalla RahulWellens JudithLiu KunTheodoratou EvropiSatsangi JackLi Xue - Diabetes-associated cognitive impairment (DACI) poses a significant challenge to the self-management of diabetes, markedly elevating the risk of adverse complications. A burgeoning body of evidence implicates microglia as a central player in the pathogenesis of DACI. - Source: PubMed
Publication date: 2024/07/20
Zhang Wen-YuanWei Qian-QianZhang TaoWang Chang-ShuiChen JingWang Jian-HuaXie XinJiang Pei - A-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. To establish a more complete understanding of the significance of AKAP8L across various types of cancers, we conducted a detailed analysis of multiple histological datasets, including the level of gene expression in pancancer, biological function, molecular characteristics, as well as the diagnostic and prognostic value of AKAP8L in pancancer. Furthermore, we focused on renal clear cell carcinoma (KIRC), and of explored the correlation of AKAP8L with clinical characteristics, prognosis of distinct patient subsets, co-expression genes and differentially expressed genes (DEG). We also performed the immunohistochemical staining and semi-quantitative verification of the monoclonal antibody established by AKAP8L. Our findings indicate that AKAP8L expression varied significantly not only across most cancer types, but also across different cancer molecules and immune subtypes. In addition, the robust ability to accurately predict cancer and its strong correlation with the prognosis of cancer strongly suggest that AKAP8L may be a potential biomarker for cancer diagnosis and prognosis. Furthermore, the high expression levels of AKAP8L were related to the worse overall survival (OS), disease-specific survival (DSS) as well as progression-free interval (PFI) of KIRC with statistical significance, especially among distinct clinical subgroups of KIRC. To sum up, AKAP8L has the potential to serve as a critical molecular biomarker for the diagnosis and prognosis of pancancer, an independent prognostic risk factor of KIRC, and a novel molecular target for cancer therapies. - Source: PubMed
Publication date: 2023/09/07
Zhou LiboMei JinhongCao RunfuLiu XiaoqiangFu BinMa MingGong BinbinLuo LianminLiu YifuZhu QiqiMeng Xuan - Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes in human excitatory neurons derived from induced pluripotent stem cells (iPSCs). The network contains newly reported interactions and is enriched for genetic and transcriptional perturbations observed in individuals with ASDs. We leveraged the network data to show that the ASD-linked brain-specific isoform of ANK2 is important for its interactions with synaptic proteins and to characterize a PTEN-AKAP8L interaction that influences neuronal growth. The IGF2BP1-3 complex emerged as a convergent point in the network that may regulate a transcriptional circuit of ASD-associated genes. Our findings showcase cell-type-specific interactomes as a framework to complement genetic and transcriptomic data and illustrate how both individual and convergent interactions can lead to biological insights into ASDs. - Source: PubMed
Publication date: 2023/01/24
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