NR6A1 Antibody - middle region (ARP31865_P050)
- Known as:
- NR6A1 Antibody - middle region (ARP31865_P050)
- Catalog number:
- arp31865_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- NR6A1 Antibody - middle region (ARP31865_P050)
Related genes to: NR6A1 Antibody - middle region (ARP31865_P050)
- Gene:
- NR6A1 NIH gene
- Name:
- nuclear receptor subfamily 6 group A member 1
- Previous symbol:
- GCNF
- Synonyms:
- GCNF1, RTR, CT150
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-22
- Date modifiied:
- 2015-11-18
Related products to: NR6A1 Antibody - middle region (ARP31865_P050)
Related articles to: NR6A1 Antibody - middle region (ARP31865_P050)
- - Source: PubMed
Publication date: 2026/04/13
Jacquinet AdelineFlasse LydieDohet ManonVanhaeren RomanePendeville HélèneSaunders CarolLehman AnnaPienkowski CatherineMorcel KarineGuerrier DanielBours VincentPeers Bernard - - Source: PubMed
Publication date: 2026/02/24
Jacquinet AdelineFlasse LydieDohet ManonVanhaeren RomanePendeville HélèneSaunders CarolLehman AnnaPienkowski CatherineMorcel KarineGuerrier DanielBours VincentPeers Bernard - Neural crest cells (NCC) are a migratory progenitor cell population unique to vertebrates that contribute to nearly every organ system throughout the body. Disruptions in NCC development can result in congenital disorders (neurocristopathies). Yet, our understanding of the cellular mechanisms and signals that govern mammalian NCC formation remains poor. Here, we discovered nuclear receptor superfamily 6 group member 1 (NR6A1/GCNF/RTR) is a novel, critical regulator of mammalian NCC specification, formation and survival. Nr6a1 expression in mouse embryos spatiotemporally overlaps with early NCC development. NR6A1 loss-of-function perturbs anterior cranial NCC formation and survival, with complete agenesis of migratory NCC caudal to the first pharyngeal arch. Using targeted molecular and genomic approaches, we demonstrate that these phenotypes are associated with perturbation of NCC specification and epithelial-mesenchymal transition, and with persistent expression of pluripotency-associated factors. Supporting these observations, in vivo overexpression of Oct4 in gastrulating mouse embryos disrupts NCC specification and formation. Conditional temporal deletion revealed that Nr6a1 is required during mid-late gastrulation, demonstrating that the initiation of murine NCC specification likely occurs during gastrulation - earlier than previously thought, but in close alignment with the established timeline of NCC development in other vertebrate model organisms. These findings also reveal that the gold standard transgenic mouse line, Wnt1-Cre, is unsuitable for studying genetic function during NCC specification and formation. In summary, NR6A1 is essential for mammalian NCC development and may function during gastrulation as a bimodal switch modulating pluripotency-associated factors in the neuroepithelium, while concomitantly activating NCC specifiers and regulators of EMT. - Source: PubMed
Publication date: 2026/01/29
Moore Zajic Emma LMuñoz William ADennis Jennifer FBhatt ShachiSakai DaisukeAchilleos AnnitaZhao RuonanLamb MaureenPrice Andrew JSeidel ChrisTiana MaríaBarral AntonioClawson DelaneyManzanares MiguelTrainor Paul A - Genomic, non-genomic, and immune alterations contribute to melanoma resistance to BRAF and MEK inhibitors. Here, we investigated the role of the SPACA6-hosted miR-99b~125a~let-7e cluster in modulating inflammatory processes and therapy resistance. We found that miR-99b, miR-125a, and let-7e were upregulated in progressing tumors from treated melanoma patients compared with untreated lesions, and in patients with short response duration compared with long-term responders. Similarly, miR-99b~125a~let-7e expression levels were high in melanoma cell lines with acquired resistance to BRAF/MEK inhibitors, showing upregulation of immunosuppressive cytokines. Combined inhibition of miR-99b, miR-125a and let-7e during drug treatment reduced proliferation of resistant cells and decreased the expression of pro-inflammatory cytokines such as CCL2, IL6, and IL8. Conversely, enforced overexpression of these miRNAs in drug sensitive cells promoted resistance and enhanced cytokine transcripts. In silico miR-99b, miR-125a and let-7e target gene analysis uncovered GNAI1, ADCY1 and NR6A1 genes in lipid metabolism pathways linked to BRAF/MEK inhibitor resistance, which converge on the activation of the mTOR signaling, and show down-regulation in resistant cells and tumors. RNA-seq and proteomic profiling of 3D cultures of patient-derived melanoma explants demonstrated that inhibition of the miR-99b~125a~let-7e cluster reprogrammed the tumor microenvironment, enhancing immune activation and suppressing mTOR signaling. Together, these findings identify the SPACA6-hosted miR-99b~125a~let-7e cluster as a regulator of BRAF/MEK inhibitor resistance through promotion of tumor survival and of an immunosuppressive microenvironment. Targeting this miRNA cluster may provide novel therapeutic opportunities to overcome drug resistance in metastatic melanoma. - Source: PubMed
Publication date: 2026/01/02
Vallacchi VivianaLupoli GianpieroShahaj EriominaAloisi MariachiaraBergamini StefanoFrigerio SimonaDe Cecco LorisVergani BarbaraTodoerti KatiaBanfi CristinaLeone Biagio EugenioDi Guardo LorenzaGallino GianfrancescoCossa MaraValeri BarbaraRivoltini LiciaHuber VeronicaRodolfo MonicaVergani Elisabetta - Donkeys () play a critical role in agricultural, transport, and livelihood systems across Asia, yet they remain among the most neglected domestic species in terms of welfare, management, and research attention. This review synthesizes recent literature on donkey welfare, health, breeding, and conservation across Asia, highlighting regional disparities and emerging challenges. A systematic review of published studies identified welfare determinants including nutrition, workload, shelter, and veterinary access. Welfare conditions are found to be poorest in South Asia, particularly in Pakistan, India, and Afghanistan, where chronic undernutrition, inadequate housing, excessive workloads, and limited veterinary support prevail. Preventive healthcare, such as vaccination and deworming, remains largely absent, reflecting low owner awareness and weak veterinary infrastructure. In contrast, China demonstrates substantial progress through semi-intensive farming systems, structured welfare management, and research-based breeding programs that integrate welfare with productivity enhancement. Recent advancements in molecular genetics have further expanded the scope of donkey conservation and improvement. Studies on key genes, including , , , , and , have elucidated their roles in vertebral number, skeletal development, and body conformation in Dezhou donkeys, offering new opportunities for genomic-level conservation and marker-assisted selection. Nonetheless, significant health challenges, such as parasitic, bacterial, and viral infections (, , and ), continue to threaten productivity and welfare. Reproductive management across most Asian countries remains traditional and uncoordinated, whereas China leads in artificial insemination, genetic resource preservation, and policy-supported breeding initiatives. Ethical concerns surrounding overexploitation and the commercial use of donkeys, particularly in the ejiao (donkey-hide gelatin) industry, are also gaining attention. Overall, this review underscores the urgent need for a "One Welfare" approach, linking Animal Welfare, human livelihoods, and sustainable industry development. Strengthening veterinary infrastructure, promoting owner education, and integrating genomic tools into breeding programs are essential steps toward improving the welfare, productivity, and long-term conservation of donkeys across Asia. - Source: PubMed
Publication date: 2025/12/01
Ullah AbdKhan Muhammad ZahoorWang Changfa