GBX2 antibody - middle region (ARP31862_T100)
- Known as:
- GBX2 (anti-) - middle region (ARP31862_T100)
- Catalog number:
- arp31862_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GBX2 antibody - middle region (ARP31862_T100)
Related genes to: GBX2 antibody - middle region (ARP31862_T100)
- Gene:
- GBX2 NIH gene
- Name:
- gastrulation brain homeobox 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q37.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-30
- Date modifiied:
- 2015-08-27
Related products to: GBX2 antibody - middle region (ARP31862_T100)
Related articles to: GBX2 antibody - middle region (ARP31862_T100)
- Hemifacial microsomia (HFM) is a genetically complex craniofacial disorder. While GWAS and family studies have identified multiple candidate genes, functional validation rates remain low (<10%). - Source: PubMed
Publication date: 2026/04/07
Li ZhifengZhang Zhiyong - - Source: PubMed
Publication date: 2026/03/23
Lu ZhengZhang ChenxiLiao YiLi YiZhou ChuxunZhu KeyuChen YiyangZeng ZhiyongYang Jingrong - - Source: PubMed
Publication date: 2025/08/21
Yang RunHan WenqingWang LiangChen XinChen YingLi BowenQian MaoxiangLiu DongZhang TianyuMa Jing - The thalamus regulates sensory processing, cognition, and sleep, yet the molecular mechanisms underlying its development remain incompletely understood. Long noncoding RNAs (lncRNAs), particularly evolutionarily conserved ones, are highly enriched in the brain. Using public mRNA databases, we screen for lncRNAs with embryonic brain expression and harboring ultraconserved non-coding elements (UCNEs) in humans and mice, identifying colorectal neoplasia differentially expressed (Crnde). It exhibits stage-specific upregulation in the embryonic thalamus. The Database of Genomic Variation and Phenotype in Humans using Ensembl Resources (DECIPHER) database suggests a potential association between Crnde and intellectual disability. Crnde-deficient mice display anxiety-like behaviors and spatial memory deficits. Furthermore, Crnde ablation increases progenitor cell numbers and impairs neuronal differentiation during embryonic thalamic development. Mechanistically, Crnde modulates the mRNA expression of gastrulation brain homeobox 2 (Gbx2), a gene critical for thalamic development. Collectively, our results implicate lncRNA Crnde in the proper progression of embryonic thalamic development in mice. - Source: PubMed
Publication date: 2026/02/06
Hu Wen-ZhuGu Ya-YunHe Yuan-LinHong YuanHe Yue-WenZhang Zi-ChengWang Yuan-HaoSun Jia-NingHan XiaoLiu YanHu Zhi-Bin - Low reprogramming efficiency and high phenotypic variability hinder the regenerative medicine applications of human pluripotent stem cells. Understanding the mechanisms that regulate pluripotency is crucial to overcoming these challenges. This study investigated the relationship between lactylation, a newly identified regulator of gene expression, pluripotency, metabolism, and lactate transport in human embryonic stem cells (hESCs). Histone lactylation levels were significantly higher in hESCs than in differentiated cells. Further, exogenous lactate increased histone lactylation and acetylation levels and altered pluripotency gene expression, notably increasing KLF4, KLF5, GBX2, and DMNT3L in hESCs. Finally, naïve-like hESC colonies exhibited higher lactylation levels peripherally, coinciding with elevated peripheral SOX2 levels. Conversely, lactate transport and production protein levels were higher centrally. This study suggests that elevated histone lysine lactylation levels are a newly identified characteristic of human pluripotency. The spatial distribution findings are consistent with a positive relationship between histone lactylation and SOX2 expression in naïve-like hESCs. - Source: PubMed
Publication date: 2026/01/30
Kozlov Alexandra MLeung Zuleika C LWilson Rachel BBhangal SukhdeepNygard KarenPowell Andrew MBorradaile Nica MBetts Dean HCumming Robert C