GATA3 antibody - N-terminal region (ARP31857_P050)
- Known as:
- GATA3 (anti-) - N-terminal region (ARP31857_P050)
- Catalog number:
- arp31857_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GATA3 antibody - N-terminal region (ARP31857_P050)
Related genes to: GATA3 antibody - N-terminal region (ARP31857_P050)
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: GATA3 antibody - N-terminal region (ARP31857_P050)
Related articles to: GATA3 antibody - N-terminal region (ARP31857_P050)
- Despite the great improvements made in its clinical management during the past decades, breast cancer remains a challenge with considerably high morbidity and mortality. Further efforts to explore new biomarkers with promising clinical potential are still needed nowadays. Collectively, our findings reveal the GATA3-RFPL3-ASK1 axis as a novel tumor-suppressive pathway in breast cancer. Mechanistically, GATA3 transcriptionally activates RFPL3 by directly binding to its promoter. Subsequently, RFPL3 stabilizes and activates ASK1 via K63-linked polyubiquitination, which in turn activates the ASK1-JNK/p38 signaling cascade. The signaling cascade induces apoptosis. Concurrently, this signaling cascade inhibits epithelial-mesenchymal transition (EMT) and invadopodia formation, thereby effectively inhibiting cell migration and invasion. The GATA3-RFPL3-ASK1 axis suppresses breast cancer growth and lung metastasis in vivo. - Source: PubMed
Publication date: 2026/04/17
Li KangLiu ChangYin Jun-HuiHe Yu-TingXu Zhi-ZhiZhang Wen-JingWang Jian-QiHou Lu-YaoFeng JingLin Le-MinDuan Xiu-QingZhou YiJi Liang - BackgroundMesonephric-like adenocarcinoma (MLA) is a rare type of Müllerian carcinoma that poses significant diagnostic challenges, especially at extrauterine sites. Its morphologic and immunophenotypic overlap with other carcinomas can lead to diagnostic confusion or misclassification.Patient PresentationWe describe a 55-year-old woman with a history of endometriosis who developed peritoneal MLA infiltrating the bowel wall, accompanied by nodal and hepatic metastases. The tumor displayed diverse architectural patterns and was composed of cuboidal to columnar cells with moderate cytologic atypia and vesicular chromatin. Immunohistochemistry showed positivity for keratin, PAX8, and TTF-1, with focal positivity for GATA3 and luminal CD10, and focal weak ER staining in <5% of cells; PR was negative. Focal thyroglobulin expression was also present. Molecular testing revealed a p.G12V activating mutation.DiscussionMLA has a broad differential diagnosis and is often misinterpreted as other neoplasms. Accurate diagnosis requires an integrated assessment of morphology, immunophenotype, and molecular profile. The peritoneal location, particularly in association with endometriosis, raises the possibility of a peritoneal origin.ConclusionPeritoneal MLA is exceptionally rare. Pathologists should consider MLA in the differential diagnosis of peritoneal tumors, particularly those arising in the setting of endometriosis, to ensure accurate classification and appropriate clinical management. - Source: PubMed
Publication date: 2026/04/16
Mohamed Khaled SabryElfatairy KareemCrow JenniferHolloway StevenLucas Elena - The polarization of naive CD4+ T cells into Th2 cells is initiated in lymphoid organs and completed as the cells become tissue resident, where they express ST2, the receptor for the alarmin interleukin (IL)-33, which may be a key signal for tissue integration. Cellular metabolic requirements associated with this transition remain poorly understood. To address this, we compared the response of lymphoid tissue (LT) Th2 cells from helminth parasite-infected mice to stimulation by IL-33 versus through the T cell receptor via anti-CD3/CD28. We found that IL-33, but not anti-CD3/CD28, induced the development of tissue-resident like Th2 cells expressing ST2. This was associated with IL-33 induced changes in arginine metabolism linked to mTORC1 activation and polyamine synthesis, which were required for the development of tissue-resident like Th2 cells. Furthermore, IL-33 induced transcriptional changes in genes involved in chemotaxis and cell adhesion that may be critical for tissue integration. Our findings provide insights into adaptations of Th2 cells responding to tissue-integration cues and more broadly support the view that IL-33 promotes the expression of the transcriptional program associated with tissue residency of GATA3-expressing cells in adipose and possibly other tissues. - Source: PubMed
Kania Anna KSanin David EGu XinyueGidley MiaKokosinski ErykSmith AllenPearce ErikaPearce Edward J - Urinary bladder lymphomas are rare and may mimic urothelial carcinoma by morphology or unexpected expression of putative "urothelial" markers such as p63/ GATA3, the latter of which has not been thoroughly explored. Herein, we evaluate the clinicopathologic features of bladder lymphomas and assess the incidence of p63/GATA3 expression. A multi-institutional review identified 28 bladder lymphomas. Slides were re-reviewed for lymphoma subtype, growth pattern, urothelial colonization, and concurrent urothelial carcinoma. Clinical features recorded including age, presentation, procedure type, and cystoscopic impression. Immunohistochemistry for p63 and GATA3 was performed and semi-quantitatively scored for staining intensity and extent. The cohort included 28 tumors (mean age 71 years; male-to-female ratio = 4:3), most of which were primary bladder lymphomas (68%). Diffuse large B-cell lymphoma was the most common subtype (53% overall). A diffuse growth pattern predominated (93%), and 32% demonstrated colonization of the overlying urothelium. Concurrent urothelial carcinoma was present in 11% of tumors. By immunohistochemistry, 57% of lymphomas showed p63 positivity and 50% showed GATA3 positivity, with dual expression in 43%. p63/GATA3 expression occurred across multiple lymphoma subtypes. Staining intensity/extent was generally low to moderate but potentially misleading in specimens with sheet-like growth or urothelial colonization. Lymphomas involving the bladder frequently show morphologic and immunophenotypic overlap with urothelial carcinoma including diffuse architecture, urothelial colonization, and p63/GATA3 expression. These shared features constitute a significant diagnostic pitfall with potential therapeutic consequences. Awareness of this overlap and use of a broad immunohistochemical panel (eg, CD45, pankeratin) are essential for accurate diagnosis in unusual bladder tumors. - Source: PubMed
Publication date: 2026/04/15
Lee TiffanyAkgul MahmutFernandez-Pol SebastianAron ManjuFalzarano SaraGalea LaurenceSangoi Ankur R - Selenium (Se) orchestrates a multilevel endogenous defense network in crops against cadmium (Cd) toxicity. This network operates from rhizosphere immobilization (e.g., Cd-Se complexes, microbiome interactions, iron plaque, and root exudates) and subcellular sequestration via transporter regulation (e.g., OsNramp5, OsHMA3) to antioxidant enhancement and selenoprotein activation. Critically, Se acts as a signaling initiator, engaging pathways (e.g., GATA3-COMT1-melatonin) to systemically reprogram stress responses. This review highlights that Se's antagonistic efficacy is form-, dose-, and genotype-dependent, providing a mechanistic basis for precision agronomic strategies. Future efforts must bridge laboratory findings to field applications by elucidating molecular switches and developing integrated predictive technologies. - Source: PubMed
Publication date: 2026/04/14
Liu JunZhang JiajieHu ShiyuJiang MengleiLin XinruHe PeishuangPeng Cuiying