ZBTB20 antibody - middle region (ARP31853_T100)
- Known as:
- ZBTB20 (anti-) - middle region (ARP31853_T100)
- Catalog number:
- arp31853_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZBTB20 antibody - middle region (ARP31853_T100)
Related genes to: ZBTB20 antibody - middle region (ARP31853_T100)
- Gene:
- ZBTB20 NIH gene
- Name:
- zinc finger and BTB domain containing 20
- Previous symbol:
- ZNF288
- Synonyms:
- ODA-8S, DKFZp566F123, DPZF
- Chromosome:
- 3q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-25
- Date modifiied:
- 2016-10-05
Related products to: ZBTB20 antibody - middle region (ARP31853_T100)
Related articles to: ZBTB20 antibody - middle region (ARP31853_T100)
- Phospholamban (PLN) is a key regulator of sarco-endoplasmic reticulum calcium ATPase (SERCA) activity and myocardial contractility, but its expression control remains incompletely understood. This study seeks to clarify the molecular mechanism of PLN regulation and its functional relevance in cardiac physiology. - Source: PubMed
Ren Qiu-XiaoLiu Ya-JinWang PingSong XiaoweiZhao QianCao Ya-NanHui Ru-TaiYang Huang-TianZhu YiWei Chun-ChunRen An-JingZhang Weiping J - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-β plaques, and neurofibrillary tangles. It's underlying mechanisms remain unclear and no disease-modifying therapies are currently available. Recent evidence has highlighted glial function as crucial factors in AD pathogenesis. Therefore, in this study, we aimed to find key AD-relevant cell populations and genes involved in glial function as well as potential therapeutic compounds. Single-cell transcriptomic data (GSE157827) and GWAS summary statistics (ieu-b-5067) were integrated using scPagwas to identify AD-associated cell subtypes and genes. Machine learning and ROC analyses were applied to refine and validate key genes, which were used to construct a diagnostic nomogram. Gene set enrichment, immune infiltration, and drug prediction analyses were performed, and the single-cell expression and pseudotime trajectories of key genes were further examined. Through scPagwas analysis, we identified oligodendrocytes and astrocytes as the major cell types associated with AD genetic risk, and revealed 27 candidate genes enriched in glial development and function, among which QKI and ZBTB20 ranked highest. Machine learning algorithms and validation across multiple independent datasets further identified QKI, ZBTB20, and C10orf90 as the key candidate genes. Single-cell analyses confirmed high expression of these genes in oligodendrocytes and astrocytes, and their dynamic, stage-associated expression patterns along glial differentiation trajectories. Drug-gene interaction and molecular docking analyses identified retinoic acid as a potential therapeutic compound targeting QKI and ZBTB20. Our findings highlighted that oligodendrocytes and astrocytes play a key role in the development of AD and provide new perspectives for future therapeutic strategies. - Source: PubMed
Chen Yu-ChaoLiu YangChen Yi-Jun - Immune ageing impairs adaptive and innate responses, yet the spleen remains underexplored by cross-cohort single-cell studies. We profiled splenocytes from young, old and chronically stressed old mice with natural microbiota using single-cell RNA sequencing. Ageing was characterised by reduced lymphocyte competence and elevated stress responses. Within Gzmk CD8 T cells, young mice were enriched for Gzmk-high cells, whereas in old mice, both Gzmk-high and Gzmk-low cells showed greater heterogeneity and functional alterations: exhaustion in Gzmk-high and inflammation in Gzmk-low cells. Natural killer (NK) cells and macrophages exhibited reduced cytotoxic potential and sustained pro-inflammatory polarisation, respectively. Chronic stress caused modest compositional shifts that partially counteracted age-related changes. Furthermore, we integrated our dataset with six published datasets to build a comprehensive atlas with > 272,000 splenocytes. Atlas-level annotation showed reproducible compositional shifts across datasets. Conserved ageing signatures included loss of NK effector genes (Zeb2, Prf1), decline of naïve T quiescence (Lef1, Il7r) with stress induction (Rbm3, Socs3), gain of survival/pro-inflammatory/exhaustion genes (Bcl2, S100a6, Ccl5, Lag3) in effector T cells, and altered differentiation and regulation (Zbtb32, Zbtb20, Zfp318, Ighd, Cr2) in B cells. Our results define conserved features of splenic immunosenescence and provide an atlas for dissecting splenic immune alterations. - Source: PubMed
Philip Chinna SusanFilippov IgorHaljasorg UkuPeterson Pärt - Genome-wide association studies (GWAS) in cattle populations have traditionally relied on progeny-derived phenotypes such as estimated breeding values as input phenotypes to identify additive quantitative trait loci (QTL) for complex traits. Increasing availability of cow genotype data now enables GWAS using own performance records to detect both additive and non-additive QTL. - Source: PubMed
Publication date: 2026/03/11
Watson NatashaHe QiongyuKadri Naveen KumarLeonard Alexander SSeefried Franz RPausch Hubert - Colorectal cancer liver metastasis (CRC-LM) carries poor prognosis and responds poorly to current immunotherapies. Liver metastases often display T-cell exclusion, but how stromal and myeloid circuits jointly shape T-cell states across primary and metastatic sites, and how to capture this in robust prognostic markers, remains unclear. - Source: PubMed
Publication date: 2026/03/10
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