SCMH1 antibody - middle region (ARP31693_P050)
- Known as:
- SCMH1 (anti-) - middle region (ARP31693_P050)
- Catalog number:
- arp31693_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SCMH1 antibody - middle region (ARP31693_P050)
Related genes to: SCMH1 antibody - middle region (ARP31693_P050)
- Gene:
- SCMH1 NIH gene
- Name:
- Scm polycomb group protein homolog 1
- Previous symbol:
- -
- Synonyms:
- Scml3
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-15
- Date modifiied:
- 2017-07-18
Related products to: SCMH1 antibody - middle region (ARP31693_P050)
Related articles to: SCMH1 antibody - middle region (ARP31693_P050)
- Aberrant circular RNA (circRNA) expression is implicated in various diseases, but the regulatory mechanisms remain poorly understood. Our previous work identified circSCMH1 as a brain repair-associated circRNA, prompting investigation into its biogenesis regulation. - Source: PubMed
Publication date: 2026/01/01
Bai YingHan BingZhang YiWen LiyingLiu ChangWang YuCui JiafangZheng BingjingCai NingboXu LianShen LingZhang YuanYao Honghong - Larger body size and enhanced reproductive performance correlate with increased profitability for sheep farmers. Notably, Hu sheep have smaller statures compared to other meat sheep breeds, necessitating improvement. Moreover, the molecular mechanisms underlying the high fecundity of Hu sheep remain unclear. Body size and reproductive traits are economically important traits in Hu sheep production, and further research is required. - Source: PubMed
Publication date: 2025/11/10
Li MaoXiang XinGao WeiZhao LiranWang ZhengguangLi Kui - Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate of mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent and nonhuman primate animal stroke models has been found. However, there are still delivery challenges to overcome for its clinical implementation. Besides, its effects on post-stroke cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established to deliver circSCMH1 and explore its therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration of circSCMH1@LNP1 significantly increases circSCMH1 distribution in the peri-infarct region and reduces its non-specific accumulation in other organs compared to intravenous injection. Therapeutic results indicate that circSCMH1@LNP1 promotes synaptic plasticity, vascular repair, neuroinflammation relief, and myelin sheath formation, thereby achieving enhanced sensorimotor and cognitive function recovery in post-stroke mice. In conclusion, this research presents a simple and effective LNP system for efficient delivery of circSCMH1 via intranasal administration to repair post-stroke brain injury. It is envisioned that this study may bridge a crucial gap between basic research and translational application, paving the way for clinical implementation of novel circSCMH1 in post-stroke patient management. - Source: PubMed
Publication date: 2025/03/27
Jia YanpengXu LianLeng ShuoSun YanHuang XinxinWang YuRen HuiLi GuanlongBai YingZhang ZhongkunHan BingShen LingJu MinziChen LehuiYao Honghong - This study investigates the genetic architecture of the Kazakh Whiteheaded (KWH) cattle, applying population genetics approaches to resequenced genomes. analysis of 66 cattle breeds identified breeds for admixture analysis. At K = 19, the composite KWH breed showed contributions from Hereford, Altai, and Kalmyk cattle. Principal component analysis and ancestry inference confirmed these patterns, with KWH genomes comprising 45% Hereford, 30% Altai, and 25% Kalmyk ancestries. Haplotype analysis revealed 73 regions under putative selection in KWH, some shared with Hereford (e.g., with the gene ) and some KWH-specific (e.g., with the gene ). F analysis identified 105 putative intervals under selection, with key genes ( and ) involved in coat colour and physiological adaptations. Functional enrichment using The Database for Annotation, Visualization, and Integrated Discovery (DAVID) in selected regions highlighted clusters associated with developmental processes, ubiquitination, and fatty acid metabolism. Point F identified 42 missense variants in genes enriched in functions related to economically important traits. Local ancestry inference revealed genomic intervals with predominantly non-Hereford ancestry, including high Altai (e.g., ) and Kalmyk (e.g., ) contributions, while Hereford-dominated regions included genes and . This work elucidates the genomic contributions and adaptive signatures of selection shaping the KWH breed, providing candidate genetic variants for breeding program improvement and enhanced genome predictions. - Source: PubMed
Publication date: 2025/01/29
Khamzina Aigerim KIgoshin Alexander VMuslimova Zhadyra UTurgumbekov Asset AKhussainov Damir MYudin Nikolay SUssenbekov Yessengali SLarkin Denis M - Metabolic dysfunction is one of the key pathological events after ischemic stroke. Disruption of cerebral blood flow impairs oxygen and energy substrate delivery, leading to mitochondrial oxidative phosphorylation dysfunction and cellular bioenergetic stress. Investigating the effects of circSCMH1, a brain repair-related circular RNA, on metabolism may identify novel therapeutic targets for stroke treatment. CircSCMH1 was encapsulated into brain-targeting extracellular vesicles (EVs) mediated by rabies virus glycoprotein (RVG). Using a mouse model of photothrombotic (PT) stroke, we employed metabolomics and transcriptomics, combined with western blotting and behavioral experiments, to identify the metabolic targets regulated in RVG-circSCMH1-EV-treated mice. Additionally, immunofluorescence staining, chromatin immunoprecipitation (ChIP), pull-down, and western blotting were utilized to elucidate the underlying mechanisms. The targeted delivery of circSCMH1 via RVG-EVs was found to promote post-stroke brain repair by enhancing mitochondrial fusion and inhibiting mitophagy through suppression of kynurenine 3-monooxygenase (KMO) expression. Mechanistically, circSCMH1 exerted its inhibitory effect on KMO expression by binding to the transcription activator STAT5B, thereby impeding its nuclear translocation. Our study reveals a novel mechanism by which circSCMH1 downregulates KMO expression, thereby enhancing mitochondrial fusion and inhibiting mitophagy, ultimately facilitating post-stroke brain repair. These findings shed new light on the role of circSCMH1 in promoting stroke recovery and underscore its potential as a therapeutic target for the treatment of ischemic stroke. - Source: PubMed
Publication date: 2024/10/28
Wang YuBai YingCai YangZhang YuanShen LingXi WenZhou ZhongqiuXu LianLiu XueHan BingYao Honghong