FOXG1 antibody - N-terminal region (ARP31686_P050)
- Known as:
- FOXG1 (anti-) - N-terminal region (ARP31686_P050)
- Catalog number:
- arp31686_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FOXG1 antibody - N-terminal region (ARP31686_P050)
Related genes to: FOXG1 antibody - N-terminal region (ARP31686_P050)
- Gene:
- FOXG1 NIH gene
- Name:
- forkhead box G1
- Previous symbol:
- FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A
- Synonyms:
- HFK2, QIN, BF1, HFK1, HFK3, HBF-3
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-07
- Date modifiied:
- 2018-05-04
- Gene:
- FOXG1-AS1 NIH gene
- Name:
- FOXG1 antisense RNA 1
- Previous symbol:
- -
- Synonyms:
- FOXG1-AS
- Chromosome:
- 14q12
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2014-06-04
- Date modifiied:
- 2018-03-23
Related products to: FOXG1 antibody - N-terminal region (ARP31686_P050)
Related articles to: FOXG1 antibody - N-terminal region (ARP31686_P050)
- Over the past decade, substantial scientific evidence has showed that long non-coding RNAs (lncRNAs) are extensively expressed and play a crucial role in gene modulation through a diverse range of transcriptional, and post-transcriptional mechanisms. Recent discoveries have emphasized the involvement of lncRNAs in maintaining cellular homeostasis and neurogenesis in the brain. Accumulating reports identified dysregulated lncRNAs associated with psychiatric disorders, including autism. In this study, we examined the expression levels of DISC2, Linc00945, Foxg1-as1, Csnk1a1p, and Evf2 lncRNAs in blood samples from 21 clinically diagnosed autistic patients based on the Diagnostic and Statistical Manual of Mental Disorders criteria-5th edition (DSM-5), compared to age, sex, and ethnically-matched 25 healthy individuals. RNA extraction and cDNA synthesis were performed, followed by real-time PCR for quantification of lncRNAs expression levels. Receiver operating characteristic (ROC) curve analysis was used to evaluate biomarker potential. Additionally, we investigated the correlation between gene expression levels and autism comorbidities. Our results showed a significant decrease in Csnk1a1p expression in patients with autism spectrum disorder (ASD) compared to healthy children (P value = 0.0008). ROC curve analysis indicated that Csnk1a1p expression levels could effectively discriminate patients from healthy controls (AUC = 0.837, P value = 0.000284). No significant differences were observed between Csnk1a1p expression levels and comorbidity with ADHD or intellectual disability (p-value > 0.05). Based on these findings, Csnk1a1p may play a significant role in autistic patients and could serve as a potential biomarker for diagnostic and predictive purposes, as well as a therapeutic target. - Source: PubMed
Publication date: 2024/11/16
Rahmani ZahraRahmani DinaJazi Marie SaghaeianGhasemi Mohammad-RezaSadeghi HosseinMiryounesi MohammadRazjouyan KatayoonFayyazi Bordbar Mohammad Reza - Approximately 50% of thymoma patients also show myasthenia gravis (MG), which is an autoimmune disease; however, the pathogenesis of MG-associated thymoma remains elusive. Our aim was to investigate immune-related lncRNA profiles of a set of candidate genes for better understanding of the molecular mechanism underlying the pathogenesis of thymoma with or without MG. Molecular profiles of thymoma with or without MG were downloaded from The Cancer Genome Atlas, and Pearson's correlation analysis was performed to identify immune-related lncRNAs. T test was used to examine the differential expression and differential methylation between thymoma patients with or without MG. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to predict the function of target genes of immune-related lncRNAs. Analyses of the 87 thymoma samples with complete MG information revealed that 205 mRNAs and 56 lncRNAs showed up-regulated expression in thymoma with MG patients, while 458 mRNAs and 84 lncRNAs showed down-regulated expression. The methylation level of three immune-related lncRNAs (AP000787.1, AC004943.1, WT1-AS, FOXG1-AS1) was significantly decreased in thymoma tissues, and the methylation level of these immune-related lncRNAs (WT1-AS: Cor = 0.368, < 0.001; FOXG1-AS1: Cor = 0.288, < 0.01; AC004943.1: Cor = -0.236, < 0.05) correlated with their expression. GO and KEGG pathway analysis revealed that targets of the immune-related lncRNA FOXG1-AS1 were enriched in small GTPase binding and herpes simplex virus 1 infection. Transcription coregulator activity and cell cycle were the most enriched pathways for targets of lncRNA AC004943.1. LncRNA WT1-AS targets were most enriched in actin binding and axon guidance. Our results revealed the immune-related molecular profiling of thymoma with MG and without MG and identified key pathways involved in the underlying molecular mechanism of thymoma-related MG. These findings provide insights for further research of potential markers for thymoma-related MG. - Source: PubMed
Publication date: 2021/10/28
Zhuang JinmanGuan MaohaoLiu MaolinLiu YuhangYang ShuyanHu ZhijianLai FancaiHe Fei