ZNF365 antibody - N-terminal region (ARP31685_T100)
- Known as:
- ZNF365 (anti-) - N-terminal region (ARP31685_T100)
- Catalog number:
- arp31685_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF365 antibody - N-terminal region (ARP31685_T100)
Related genes to: ZNF365 antibody - N-terminal region (ARP31685_T100)
- Gene:
- ZNF365 NIH gene
- Name:
- zinc finger protein 365
- Previous symbol:
- -
- Synonyms:
- KIAA0844, UAN
- Chromosome:
- 10q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-13
- Date modifiied:
- 2014-11-18
Related products to: ZNF365 antibody - N-terminal region (ARP31685_T100)
Related articles to: ZNF365 antibody - N-terminal region (ARP31685_T100)
- Ultraviolet exposure is the main environmental risk factor for non-melanoma skin cancers (NMSCs), but genetic susceptibility also contributes to variability in disease burden among individuals. - Source: PubMed
Publication date: 2026/04/11
Campana IreneMinafò Ylenia AuraScaglione Giovanni LucaGiovanardi GiuliaCosio TerenzioLanna CaterinaArtosi FabioLambiase SaraValente CarolaBartolocci ValeriaMorelli MartinaAlbanesi CristinaPalese EnzoMinieri MarilenaGiovannelli AlfredoAvitabile DanieleSalcedo Nidia MargotMastroeni SimonaMazzanti CinziaAbeni DamianoCampione ElenaFania LucaDellambra Elena - Circadian rhythm disorders are epidemiologically linked to colorectal cancer (CRC), but causal relationships and molecular mechanisms remain unclear. We applied a multi-omics Mendelian Randomization (SMR) framework to assess the causal effects of circadian rhythm-related genes on CRC. Instrumental variables were derived from blood-based QTLs for methylation (mQTL), expression (eQTL), and protein levels (pQTL), with validation using tissue-level eQTLs. Summary data for CRC came from the FinnGen R12 GWAS. Colocalization analyses confirmed shared genetic variants. Candidate genes were further evaluated for expression and prognostic value using TCGA and GEPIA2. Through blood-level SMR analysis, we identified 142 methylation loci, 11 genes, and 2 proteins associated with CRC in discovery cohort. Among them, 42 methylation loci, 3 genes, and 2 proteins were colocalized with CRC incidence. Our SMR analysis highlighted GRHPR as a key gene, which is negatively correlated with CRC risk at multiple molecular levels (m/e/pQTL), supported by robust colocalization evidence. Meanwhile, eQTL results showed that high level expression of UVSSA was positively associated with CRC risk. QTL results at the tissue level (Colon_Sigmoid and Colon_Transverse) support a causal relationship between the genes GRHPR and UVSSA and CRC. Crucially, survival analyses revealed that genetically predicted effects of NAF1 and ZNF365 on CRC risk were highly consistent with their prognostic values in clinical outcomes (OS and RFS). However, transcriptome expression profiling of the TCGA database CRC cohort revealed no significant differential expression of GRHPR between CRC and normal tissues, though its expression positively correlated with tumor purity. This integrated multi-omics MR analysis identified 12 circadian rhythm-related genes with potential causal relationships to CRC, highlighting GRHPR as a risk-reducing factor, and NAF1 and ZNF365 as potential dual-purpose biomarkers for both risk stratification and prognosis. The study provides new insights into regulatory mechanisms and signaling pathways, offering novel clues for future mechanistic research and targeted therapies. - Source: PubMed
Publication date: 2026/03/09
Shen ZhengjieTao MinxianQin YinTang WenkaiYuan YuanGu Wenzhe - Epidemiological evidence suggests a link between schizophrenia (SCZ) and increased breast cancer (BC) risk, but the genetic mechanisms remain unclear. Exploring their shared genetic susceptibility may help reveal the basis of this comorbidity. - Source: PubMed
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