Foxj3 antibody - middle region (ARP31683_P050)
- Known as:
- Foxj3 (anti-) - middle region (ARP31683_P050)
- Catalog number:
- arp31683_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Foxj3 antibody - middle region (ARP31683_P050)
Related genes to: Foxj3 antibody - middle region (ARP31683_P050)
- Gene:
- FOXJ3 NIH gene
- Name:
- forkhead box J3
- Previous symbol:
- -
- Synonyms:
- KIAA1041
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-22
- Date modifiied:
- 2014-11-18
Related products to: Foxj3 antibody - middle region (ARP31683_P050)
Related articles to: Foxj3 antibody - middle region (ARP31683_P050)
- Neuronal hyperexcitability often results from impaired inhibition; however, the upstream regulators of GABAergic gene programs remain unclear. We identified a role for terfa, the zebrafish ortholog of human TERF2, in maintaining inhibitory tone and network stability. Homozygous terfa mutant larvae exhibit microcephaly, behavioral hyperactivity, and abnormal neuronal calcium dynamics, indicating a hyperexcitable state. Transcriptomic and RT-qPCR analyses showed coordinated downregulation of multiple GABA receptor subunit genes, accompanied by reduced gad1b reporter activity in the optic tectum. Pharmacological enhancement of inhibition with etomidate or valproic acid alleviated seizure-like behaviors and normalized calcium activity, supporting impaired inhibition as a major contributor to neuronal hyperexcitability. Integrative ATAC-seq and RNA-seq analyses suggested altered chromatin accessibility near GABA loci that were enriched in FOX family motifs. Mechanistically, Terfa physically associates with Foxj3 and attenuates Foxj3-dependent repression of GABA promoters. These findings define a Terfa-Foxj3-GABA regulatory axis that links telomere-associated factors to inhibitory control and neuronal excitability in a vertebrate model. - Source: PubMed
Publication date: 2026/09/26
He JialingSong ZhihongZhang JiayiZhao BaoquanBao GuoLi NanZhang ChangyongMa YuanyuanGroot Marie LouiseWang TianqiZhang Bo - The 5' mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5' leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor Analysis Consortium proteogenomic cohorts. Tumor-associated shifts frequently opposed normal tissue aging trajectories, with the clearest signals in lung adenocarcinoma and lung squamous cell carcinoma. Raw closed-uORF burden defined the sharpest paired-supported lung cores, whereas residualized closed-uORF burden provided the most stable length-independent signal. Colon adenocarcinoma reproduced the transcriptomic pattern but showed a prominent adjacent-normal field effect, with nontumor colon already shifted toward the tumor pattern relative to healthy colon. Upstream-initiation features did not improve proteome-wide prediction beyond mRNA abundance but showed modest, gene-selective associations within independently prioritized age-opposed lung gene sets. Recurrent proteogenomic anchors included and . These findings define an age-opposed, tissue-dependent pattern of 5' leader remodeling and prioritize specific genes and isoforms for functional investigation. - Source: PubMed
Publication date: 2026/08/18
Pal AyonPal RanavRoy VivekChaki Madhumita GRoy Bhaskar - Alveolar type II epithelial cells (AT2), notable for their high mitochondria content, are essential for maintaining pulmonary homeostasis. However, how mitochondrial function was transcriptionally programmed during AT2 aging remains poorly understood. Here, we used single-cell transcriptome data from 28 healthy human lungs spanning various ages to systematically profile age-related transcriptional changes. Our data suggest that most classical aging markers remained stable with no significant changes during AT2 aging. Using high-dimensional weighted gene co-expression network analysis (hdWGCNA), we identified a gene expression module (M1) that declines during AT2 aging and is enriched for genes involved in mitochondrial respiration. Moreover, by integrating bioinformatic and experimental approaches, we found three transcription factors (TCF7L2, FOXJ3, and TCF7) that play key regulatory roles in controlling expression of mitochondrial respiration-related genes during AT2 aging. Collectively, our findings provide both a transcriptional framework and candidate mitochondria regulators to facilitate future investigation of the causal links between AT2 mitochondrial respiration dysfunction and age-related decline in lung function. - Source: PubMed
Publication date: 2026/06/11
Chen LuHu SiluTang XiaojuWang YujunZou YingLuo FengmingWan Huajing - Sex-determining region Y-box transcription factor 2 ( SOX2) has been implicated in tumorigenesis across various cancers. This study sought to characterize the expression pattern of SOX2 in hepatocellular carcinoma (HCC) and elucidate its potential mechanism in promoting HCC progression by targeting Forkhead box J3 (FOXJ3) and regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway, autophagy, and mitophagy. - Source: PubMed
Publication date: 2026/05/14
Zhang ZhigangRen Wanhua - - Source: PubMed
Publication date: 2026/05/30
Bedrosian Tracy A